Graham Rena

RAF inhibitors activate the integrated stress response by direct activation of GCN2 - Nature Communications Three BRAF inhibitors are used to treat melanoma and colorectal cancer. Here, the authors demonstrate that these drugs bind and activate the protein kinase GCN2, a previously unappreciated off-target ...

I’m really pleased to share the link to a new Cook Lab paper published today in Nature Communications.
www.nature.com/articles/s41...

Very nice indeed to catch up with people from my MRC PPU days as Prof Susanna Fagerholm gave today’s seminar. Susanna is currently visiting Scotland as a Global Fellow at St Andrews. Philip Cohen was Susanna’s PhD supervisor when I was a postdoc, and Jean Harthill was a postdoc then too.

I’m Still Standing

If only they knew

Academic faculty life is putting in grant applications to create your own dream post-doc position which will be filled by someone whose dream job is actually your faculty position.

Our review on Protein Synthesis and Metabolism in T cells is out @annualreviews.bsky.social @cantrell-lab.bsky.social
Protein Synthesis and Metabolism in T Cells #proteomics #immunometabolism #Tcells
www.annualreviews.org/content/jour...

Congrats to Ian Ganley of Dundee University on winning the #BSCB Hooke Medal 🥇for his outstanding work on mitophagy 🎉🎉🌟

Loch Muick today 🏃‍♂️

Large-Scale Protein Production and Activity Assay Protocols for Human Glycogen Synthase-Glycogenin Complex Glycogen synthase (GS) is the rate-limiting enzyme for glycogen production and together with glycogenin (GN) and glycogen branching enzyme (GBE), can generate glycogen particles containing up to 50,00...

Out now: Our method article describing large scale production & enzyme activity measurements of human glycogen synthase-glycogenin (GS-GN) complex published in the MIMB book series. Lead by researcher, Dipsikha Biswas & in collaboration with @zeqiraj.bsky.social @universityofleeds.bsky.social

a movie poster for the star wars saga continues ALT: a movie poster for the star wars saga continues

First movie I remember seeing in a cinema was…

Short but sweet study on inflammatory effects of 7-ketocholesterol, strongly associated with atherosclerotic CVD. Main take home-> 7-KC potentiates effects of LPS on macrophage cytokine secretion. Great to see further work coming out of Iain Phair’s postdoc and big thanks to BHF for funding 😁

Really pleased to have our latest paper accepted, out now in JMCC+ 🎉 www.sciencedirect.com/science/arti...

‘You never turned around to see the frowns on the jugglers and the clowns when they all did tricks for you‘

‘Tis the season to be merry

Ummmm 😆

Social awkwardness