Sool Lee

Very excited to share our preprint led by M. Levin @skoyama.bsky.social J. Woerner & with S. Damrauer assessing genome-wide pleiotropy of >1,000 clinical traits across ~1.7M individuals with nearly 30K locus-trait associations!
www.medrxiv.org/content/10.1... @medrxivpreprint.bsky.social

Intergenerational transmission of complex traits and the offspring methylome - Molecular Psychiatry Molecular Psychiatry - Intergenerational transmission of complex traits and the offspring methylome

Our new study in Molecular Psychiatry, in 1528 children and their parents (@ntrbiopsy.bsky.social) shows that indirect genetic effects—where parental genetics shape offspring traits via environmental influences (genetic nurture)—impact DNA methylation of children. doi.org/10.1038/s413... (1/5)

👇🎯 The public isn't going to understand this, unless the presidents of R1 universities around the country <loudly> & <collectively> get out into the public square & start explaining this & calling out the existential threat to the entire 🇺🇸 university system. The silence is deafening right now.

Massively parallel reporter assay investigates shared genetic variants of eight psychiatric disorders High-throughput experimental validation of genetic variants linked to eight psychiatric disorders reveals the regulatory mechanisms underlying variants with pleiotropic and disorder-specific effects.

1/ I am beyond thrilled to share our new paper in @CellCellPress! We explored the regulatory principles underlying pleiotropy in psychiatric disorders.
www.cell.com/cell/abstrac...

Massively parallel reporter assay investigates shared genetic variants of eight psychiatric disorders
@cellcellpress.bsky.social @hyejungwon.bsky.social
cell.com/cell/fulltex...

How population stratification makes environments look like genes. A short 🧵:

People often ask me what I use to create my plots. I use mostly R, but I have to admit that I cheat a little bit with Adobe Illustrator 🧑🏽‍🎨

See slide show below for some of my edits 👇🏽

Some thoughts about what I am looking forward this year from my vantage point of computational molecular biology. One mega-trend for me; we will definitely see more AI methods of all sorts emerge.

🎉🎉🎉

Our ChromBPNet preprint out!

www.biorxiv.org/content/10.1...

Huge congrats to Anusri! This was quite a slog (for both of us) but we r very proud of this one! It is a long read but worth it IMHO. Methods r in the supp. materials. Bluetorial coming soon below 1/

A progress bar showing that 2025 is 0% complete.

2025 is 0% complete.

Q-rich activation domains: flexible ‘rulers’ for transcription start site selection? Recent findings broadened the function of RNA polymerase II (Pol II) proximal promoter motifs from quantitative regulators of transcription to important determinants of transcription start site (TSS) position. These motifs are recognized by transcription factors (TFs) that we propose to term ‘ruler’ TFs (rTFs), such as NRF1, NF-Y, YY1, ZNF143, BANP, and members of the SP, ETS, and CRE families, sharing as a common feature a glutamine-rich (Q-rich) effector domain also enriched in valine, isoleucine, and threonine (QVIT-rich). We propose that rTFs guide TSS location by constraining the position of the pre-initiation complex (PIC) during its promoter recognition phase through a specialized, and still enigmatic, class of activation domains.

We wrote an opinion article inspired by the recent exciting reports on the sequence determinants of TSS selection + old observations on TFs activation domains. More posts on this soon!

Q-rich activation domains: flexible ‘rulers’ for transcription start site selection?
www.cell.com/trends/genet...

Specificity, length, and luck: How genes are prioritized by rare and common variant association studies Standard genome-wide association studies (GWAS) and rare variant burden tests are essential tools for identifying trait-relevant genes. Although these methods are conceptually similar, we show by anal...

What do GWAS and rare variant burden tests discover, and why?

Do these studies find the most IMPORTANT genes? If not, how DO they rank genes?

Here we present a surprising result: these studies actually test for SPECIFICITY! A 🧵on what this means... (🧪🧬)

www.biorxiv.org/content/10.1...

Specificity, length, and luck: How genes are prioritized by rare and common variant association studies https://www.biorxiv.org/content/10.1101/2024.12.12.628073v1