Nature Reviews Rheumatology (@natrevrheum.nature.com)

Neurodevelopmental comorbidities in juvenile systemic autoimmune and autoinflammatory diseases Nature Reviews Rheumatology, Published online: 02 March 2026; doi:10.1038/s41584-026-01356-8Neurodevelopmental disorders frequently co-occur with juvenile systemic autoimmune and autoinflammatory diseases, driven by immune–neurodevelopmental interactions. Early screening, multidisciplinary care and personalized interventions are essential, alongside research into mechanisms, biomarkers and long-term outcomes to improve education, psychosocial wellbeing and quality of life.

07.03.2026 17:34 👍 4 🔁 2 💬 0 📌 0

Bridging the gap: combining treat-to-target and difficult-to-treat strategies in the management of rheumatoid arthritis Nature Reviews Rheumatology, Published online: 02 March 2026; doi:10.1038/s41584-026-01354-wIn this Perspective, the authors discuss how integrating difficult-to-treat into the treat-to-target strategy could improve outcomes for those patients with rheumatoid arthritis who do not follow the standard treat-to-target trajectory. The proposed strategy is aimed at providing a more personalized approach to disease management for those patients with difficult-to-treat disease.

07.03.2026 16:31 👍 0 🔁 0 💬 0 📌 0

Women’s health Research into women’s health has suffered from historical neglect and lack of funding.

To mark International Women's Day on 8th March #IWD2026, the #NatureReviews Collection on women's health has been updated (go.nature.com/30kDWG3). The Collection covers various aspects of women's health and includes a new Primer on ovarian cancer from @natrevdiseaseprimers.nature.com

06.03.2026 12:19 👍 15 🔁 13 💬 0 📌 0

Review @natrevrheum.nature.com
Bridging the gap: combining treat-to-target and difficult-to-treat strategies in the management of rheumatoid arthritis
www.nature.com/articles/s41...

03.03.2026 16:01 👍 6 🔁 3 💬 0 📌 0

Identifying fibromyalgia phenotypes based on psychological symptom burden Nature Reviews Rheumatology, Published online: 26 February 2026; doi:10.1038/s41584-026-01362-wPsychological symptoms have a pivotal role in determining the severity of fibromyalgia. Findings now show that identifying and managing these symptoms during the early stages of disease could reveal disease phenotypes and improve the management of fibromyalgia.

03.03.2026 15:05 👍 0 🔁 0 💬 0 📌 0

Neurodevelopmental comorbidities in juvenile systemic autoimmune and autoinflammatory diseases Nature Reviews Rheumatology, Published online: 02 March 2026; doi:10.1038/s41584-026-01356-8Neurodevelopmental disorders frequently co-occur with juvenile systemic autoimmune and autoinflammatory diseases, driven by immune–neurodevelopmental interactions. Early screening, multidisciplinary care and personalized interventions are essential, alongside research into mechanisms, biomarkers and long-term outcomes to improve education, psychosocial wellbeing and quality of life.

02.03.2026 17:33 👍 0 🔁 0 💬 0 📌 0

Bridging the gap: combining treat-to-target and difficult-to-treat strategies in the management of rheumatoid arthritis Nature Reviews Rheumatology, Published online: 02 March 2026; doi:10.1038/s41584-026-01354-wIn this Perspective, the authors discuss how integrating difficult-to-treat into the treat-to-target strategy could improve outcomes for those patients with rheumatoid arthritis who do not follow the standard treat-to-target trajectory. The proposed strategy is aimed at providing a more personalized approach to disease management for those patients with difficult-to-treat disease.

02.03.2026 16:30 👍 0 🔁 1 💬 0 📌 0

What rheumatology can learn from oncology: a patient’s perspective Nature Reviews Rheumatology, Published online: 25 February 2026; doi:10.1038/s41584-026-01364-8Drawing on my contrasting experiences as a patient in oncology and rheumatology, I have seen how the lack of precision-based diagnostics and meaningful endpoints limits progress in rheumatic disease. I believe biologically grounded classification systems and greater patient involvement are essential for more effective and responsive care.

02.03.2026 13:41 👍 0 🔁 0 💬 0 📌 0

Metabolic masqueraders of paediatric and adult rheumatic diseases Nature Reviews Rheumatology, Published online: 25 February 2026; doi:10.1038/s41584-026-01352-yInborn errors of metabolism are a diverse group of disorders that can mimic rheumatological disease, often presenting with progressive joint and systemic involvement. This Review serves as a primer for rheumatologists, covering clinical aspects and potential mechanisms by which these metabolic alterations cause immune dysregulation.

02.03.2026 13:41 👍 1 🔁 0 💬 0 📌 0

Identifying fibromyalgia phenotypes based on psychological symptom burden Nature Reviews Rheumatology, Published online: 26 February 2026; doi:10.1038/s41584-026-01362-wPsychological symptoms have a pivotal role in determining the severity of fibromyalgia. Findings now show that identifying and managing these symptoms during the early stages of disease could reveal disease phenotypes and improve the management of fibromyalgia.

26.02.2026 15:04 👍 2 🔁 0 💬 0 📌 0

Engineered sialylated IgG1 Fc as a dose-sparing alternative to IVIG - Nature Reviews Rheumatology Intravenous immunoglobulin (IVIG) is a cornerstone of autoimmune disease therapy, but its use is constrained by high costs and limited supply. A sialylated IgG1 Fc variant with enhanced affinity for t...

✨March Issue✨| Engineered sialylated IgG1 Fc as a dose-sparing alternative to IVIG

This News & Views discusses a sialylated IgG1 Fc variant as a potential lower dose alternative to IVIG for autoimmune diseases.

dlvr.it/TQGpPK

26.02.2026 10:46 👍 0 🔁 0 💬 0 📌 0

The future of autologous stem cell transplantation in systemic sclerosis - Nature Reviews Rheumatology Autologous haematopoietic stem cell transplantation revolutionized the treatment of severe systemic sclerosis as the first therapy able to induce long-term remission in this relentlessly fibrosing dis...

✨March Issue✨| The future of autologous stem cell transplantation in systemic sclerosis

This Comment discusses the impact of stem cell transplantation in severe SSc and the need for clearer patient selection, conditioning strategies and more precise therapeutic approaches.

bit.ly/4iW1usj

26.02.2026 10:41 👍 0 🔁 0 💬 0 📌 0

Cam morphology and the development of femoroacetabular impingement syndrome and hip osteoarthritis - Nature Reviews Rheumatology Cam morphology can cause intra-articular joint damage and lead to femoroacetabular impingement syndrome and eventually hip osteoarthritis. This Review explores the development and effect of cam morpho...

✨March Issue✨| Cam morphology and the development of femoroacetabular impingement syndrome and hip osteoarthritis

This Review discusses cam morphology and its links to femoroacetabular impingement syndrome and hip osteoarthritis.

bit.ly/44K6n1w

26.02.2026 10:37 👍 2 🔁 1 💬 1 📌 0

Inflammation and pain as interconnected targets in axial spondyloarthritis - Nature Reviews Rheumatology Although current treatments for axial spondyloarthritis can reduce inflammation, many patients continue to experience pain. This Review examines the complex interplay between pain and inflammation in ...

✨March Issue✨| Inflammation and pain as interconnected targets in axial spondyloarthritis

This Review examines the link between pain and inflammation in axial spondyloarthritis and supports targeting both to improve outcomes.

dlvr.it/TQZBGW

26.02.2026 10:34 👍 1 🔁 1 💬 0 📌 0

Endosome traffic in rheumatic diseases: mechanistic insights and therapeutic opportunities - Nature Reviews Rheumatology Endosomal traffic orchestrates important immune functions, including receptor signalling, antigen processing and metabolic regulation, and has a pivotal role in maintaining self-tolerance. Disruption ...

✨March Issue✨| Endosome traffic in rheumatic diseases: mechanistic insights and therapeutic opportunities

This Review highlights the role of endosomal trafficking in immunity and how defects in these pathways drive autoimmune disease.

bit.ly/4pyKZon

26.02.2026 10:31 👍 0 🔁 0 💬 0 📌 0

The obesity–inflammation axis in psoriatic disease: mechanisms and therapeutic strategies - Nature Reviews Rheumatology This Review explores the complex relationship between obesity and psoriatic disease. The authors highlight the underlying mechanisms that drive this association and propose a comprehensive approach to...

✨March Issue✨| The obesity–inflammation axis in psoriatic disease: mechanisms and therapeutic strategies

This Review explores the complex relationship between obesity and psoriatic disease, outlines strategies to manage both more effectively.

bit.ly/48ku3up

26.02.2026 10:29 👍 0 🔁 0 💬 0 📌 0

✨March Issue✨| Featuring articles on:

- The obesity–inflammation axis in psoriatic disease
- Endosome traffic in rheumatic diseases
- Inflammation and pain in axSpA
- Cam morphology and hip OA

bit.ly/4kSRVeq

#Rheumsky #Medsky

26.02.2026 10:22 👍 0 🔁 0 💬 0 📌 0

Review @natrevrheum.nature.com @bcmfromthelabs.bsky.social
Metabolic masqueraders of paediatric and adult rheumatic diseases
www.nature.com/articles/s41...

26.02.2026 02:58 👍 1 🔁 3 💬 0 📌 0

What rheumatology can learn from oncology: a patient’s perspective Nature Reviews Rheumatology, Published online: 25 February 2026; doi:10.1038/s41584-026-01364-8Drawing on my contrasting experiences as a patient in oncology and rheumatology, I have seen how the lack of precision-based diagnostics and meaningful endpoints limits progress in rheumatic disease. I believe biologically grounded classification systems and greater patient involvement are essential for more effective and responsive care.

25.02.2026 13:40 👍 1 🔁 0 💬 1 📌 0

Metabolic masqueraders of paediatric and adult rheumatic diseases Nature Reviews Rheumatology, Published online: 25 February 2026; doi:10.1038/s41584-026-01352-yInborn errors of metabolism are a diverse group of disorders that can mimic rheumatological disease, often presenting with progressive joint and systemic involvement. This Review serves as a primer for rheumatologists, covering clinical aspects and potential mechanisms by which these metabolic alterations cause immune dysregulation.

25.02.2026 13:40 👍 1 🔁 0 💬 0 📌 0

Vasculitis Vasculitis is characterized by inflammation of blood vessels, which can cause vessel walls to thicken, narrow or weaken, resulting in reduced blood flow and ...

📣 Our new vasculitis collection is live!

www.nature.com/collections/...

Explore key scientific and clinical advances from the past decade, captured in Reviews, Guidelines and Commentaries.

23.02.2026 13:42 👍 3 🔁 2 💬 0 📌 0