Kathirvel Alagesan

Targeting the translation machinery: The RNase Y specificity factor Y-complex coordinates ribosome degradation Limiting the synthesis and activity of ribosomes is crucial for responding to various stresses, including nutrient starvation or proteotoxic stress. In Bacillus subtilis, this can be achieved through the coordinated action of the alarmones (p)ppGpp and the transcription factor Spx. In this study, we performed a genetic screen to identify new factors involved in the heat shock response of B. subtilis . We discovered that the RNase Y specificity factor Y-complex plays an important role in the heat shock response and the transition to the stationary growth phase. The Y-complex is required for the processing of various RNAs, including the maturation of mRNAs encoding proteins involved in translation and metabolism. We further demonstrate that the Y-complex and RNase Y initiate the degradation of rRNAs in mature ribosomes, lowering their abundance. We propose the Y-complex as a system by which B. subtilis regulates protein synthesis and resource allocation after exponential growth. ### Competing Interest Statement The authors have declared no competing interest. Max Planck Society Deutsche Forschungsgemeinschaft, https://ror.org/018mejw64

Under stress, Bacillus subtilis cuts back on protein synthesis by degrading ribosomes — and the Y-complex is the key. This helps reshape the cell’s priorities during heat shock and transition to stationary phase #MicrobialStress #RNA #subtiwiki
@fabianbsf.bsky.social

www.biorxiv.org/content/10.1...

Sex Differences in Drosophila Intestinal Metabolism Contribute to Sexually Dimorphic Infection Outcome and Alter Gut Pathogen Virulence Sexual dimorphism in infection outcomes is a pervasive phenomenon, the underlying mechanisms of which remain incompletely understood. Here, utilizing Pseudomonas entomophila intestinal infection in Dr...

Happy to share our new preprint! We explored the mechanisms underlying differences between male and female #Drosophila in susceptibility to intestinal #infection. #symbiosky
#immunity #AcademicSky #insect #symbiosis

PhD Position in glycan synthesis and analysis

Join us for a #PhD in #glycotimes!

You'll be part of a collaboration between my group and Yu Ogawa's group at the @mpici.bsky.social to design carbohydrates that fold and assemble on demand.

#chemistryjobs #researchjobs

jobs.mpikg.mpg.de/jobposting/e...

#glycoboi

Sexiest glycoboi

#glycotime @kathiralagesan.bsky.social