Sara R. Fagerlie, PhD, CHCP

"There was a palpable sense of anxiety, if not fear." Rick Pazdur, MD talks candidly about today's FDA and leaving the agency after 26 yrs of building their #oncology program. Check out Ep27 of #OncologyUnscripted at cancercommunicator.com/ou-pazdur
#FDA #MedSky #OncSky

Tragic. Please pass this along to US Chairs and Deans, and consider it when you sit on promotion committees. This, combined with the review backlog, is dire - especially for our early career researchers.

Major US cohort reveals sharp racial disparities in HIV acquisition among trans women At the Conference on Retroviruses and Opportunistic Infections (CROI 2026) held in Denver last week, Dr Sari Reisner from the University of Michigan presented data on how many transgender women in a n...

Trans identity has been erased from federally collected data and barriers erected against trans people accessing HIV prevention and care in the US.
Gender affirming prevention and care and inclusive data collection for this population, with acute HIV need, is vital.

Serotonin Modulates Lineage Plasticity in Neuroendocrine Prostate Cancer via Epigenetic Reprogramming

aacrjournals.org/cancerdiscov...

Patients say measles 'worse than expected' as Utah hits 350+ infections, doctors say Health officials plead with residents to vaccinate against measles as Utah hits 358 infections.

120 hospitalized

Crosstalk between EZH2 and DNA methylation mediates neuroendocrine prostate cancer lineage plasticity

www.nature.com/articles/s41...

A more complete set of voices in a companion piece.

www.cnn.com/2026/03/05/h...

I just tried to register.

The March date is already listed as Full!

I did register for the April date. You have a chance to enter questions. I don't know if there will be another opportunity to do this.

USPSTF Meeting Pushed Back for Third Time in a Row Meeting will be 'rescheduled in the coming months,' according to HHS

The meeting of the United States Preventative Services Task Force has been canceled again—another attack on public health by RFK Jr.

This is an independent group that reviews scientific research for things like cancer screenings. Their recommendations must be covered by insurance.

MAHA!

An independent panel of medical experts that shapes preventive care for patients in the United States will not hold its regular meeting this month, marking one year since its members last gathered. https://cnn.it/4r99NDw

“We’re seeing a big boom in private menopause clinics… sometimes that is appropriate. But at the same time, it’s a huge opportunity for wellness grift.” — @docmcohen.medsky.social to @namshine.bsky.social on an upcoming (MIS)Treated podcasts.apple.com/ca/podcast/m...

Turmoil Takes Hold at CDC as Top Officials Keep Leaving Trump plans to nominate a new director at the nation’s top health agency following months of upheaval.

The Trump administration intends to nominate a new CDC director in the coming weeks, people familiar with the matter said, following months of upheaval at the nation’s top health agency.

RFK Jr. May Eliminate the USPSTF, Original Task Force Members Warn Dismantling the task force would be 'an existential threat to clinical practice,' they said

What we heard this week ⬇️ #MedSky

"The situation is alarming." -- Robert Lawrence, MD, of @jhu.edu, warning that HHS could eliminate or delegitimize the U.S. Preventive Services Task Force.
www.medpagetoday.com/primarycare/...

White House stalls release of approved US science budgets The US Congress rejected sweeping cuts to science agencies. But the NIH, the NSF and NASA have had their spending slowed.

Congress rejected massive cuts to US science budgets for 2026, but much of the money still isn’t flowing to researchers.

The culprit? The White House Office of Management and Budget (OMB) is quietly slow-walking the release of funds. 🧵👇

A line graph showing NSF grant awards made through 2/27/26 for fiscal year 2026 compared with grant awards for fiscal years 2021-2025.

NSF Update (Awards through 2/27/26)

Directorates to follow

1/10

Kennedy announces new vaccine advisory committee members after meeting rescheduled Kennedy adds two new members to the CDC's vaccine advisory committee

Health Secretary Kennedy announced two new committee members to join the CDC (Centers for disease control) Advisory Committee on Immunization Practices (ACIP). At least one of them is an anti-vaxxer and pushed back against COVID-19 vaaccination during the pandemic sugges...

TAT: [Attacking Science]

Key NIH research institute told to remove references to 'pandemic preparedness' Staff members have been instructed to scrub this topic and ‘biodefense’ from the agency’s website, a Nature investigation finds

"Staff members at the United States’s premier infectious-disease research institute have been instructed to remove the words “biodefense” and “pandemic preparedness” from the institute’s web pages, according to e-mails Nature has obtained."

IF WE DON'T PREPARE, IT WON'T HAPPEN????

AI help in grant proposals tied to higher funding odds at NIH But funding proposals to US agencies also tend to be more similar to previously funded projects if they are written or edited with the help of a chatbot.

“We could be on a path towards homogeneity”

Data suggests that AI-assisted grant proposals are less distinct, and more likely to be funded
go.nature.com/4kDs5Lw

These charts tell a story..."Industry analysts estimate that China now accounts for 70–95% of the global supply chain for many essential pharmaceutical products...In 2024, Chinese biotechnology firms developed > 1,250 new drugs, surpassing the European Union and approaching the US total of ~1,440"

3 Policy Moves Likely to Change Health Care for Older People

I don't like any of these - gift article www.nytimes.com/2026/01/17/h...

Modernizing data and data science infrastructure as a strategic asset for cancer center - npj Health Systems npj Health Systems - Modernizing data and data science infrastructure as a strategic asset for cancer center

Modernizing data and data science infrastructure as a strategic asset for cancer center

www.nature.com/articles/s44...

Pazdur warns that politics, ‘chaos’ are damaging FDA At a STAT event, veteran drug regulator Richard Pazdur, who left the FDA last month after 26 years, said that politics and 'chaos' were damaging the agency.

Pazdur warns that politics, ‘chaos’ are damaging FDA www.statnews.com/2026/01/13/r... via @statnews.com

Excellent presentation on Resistance to Treatments Targeting the RAS/RAF/MEK Pathways by Sandra Misale, PhD,
Johns Hopkins at #GI26
Genetic, nongenetic mechanisms, reshaping TME. Different patterns of resistance seen between inhibitors of specific KRAS alleles vs pan-RAS inhibitors.

Opinion | Trump’s Cuts Are About to Make Health Care Even Worse

"We’re dismantling some of our tattered safety net and risking the lives of fellow Americans." Worth the read. Gift article #medsky #Medicaid impacts of #bigbeautifulbill
www.nytimes.com/2026/01/03/o...

JAMA Most views articles of 2025. #MEDSKY bit.ly/3KZh7CK

🚨HER2CLIMB05 🚨
🔹Pts HER2+ MBC s/p THP x 4-8 cycles ➡️ HP + tucatinib vs HP
🔹PFS 24.9m vs 16.3m p<.0001
🔹HR- 24.9m vs 12.6m
🔹HR+ 25m vs 18m
⚠️ Increase in diarrhea and hepatic AEs
🔹Control arm had inferior PFS when compared to DB-09 control arm
#SABCS25 #bcsm

📣lidERA trial📣
🔸Pts with HR+ eBC high/medium risk ➡️ giredestrant vs SOC ET x 5 years
🔸At 32 m, iDFS events 6.7% vs 9.4%, HR 0.7, p=.0014
🔸Arthralgias similar
📍1st trial to report benefit of SERD in the adjuvant tx
📋Looking forward to further data & other trials including CDK4/6i & SERDs💊
#SABCS25

Good morning ☀️ Your Day 2 research recap from the San Antonio Breast Cancer Symposium is here! Check out the highlights now: https://bit.ly/SABCS25

#SABCS25 #breastcancerresearch #BreastCancerNews #BreastCancer #breastcancerawareness

LBCA was proud to sponsor the special session on lobular breast cancer at SABCS! #ILC #ILCawareness #lobularbreastcancer #SABCS25

A new, highly sensitive liquid biopsy test may better detect minimal residual disease (MRD) — tiny traces of cancer left after treatment. This could one day help identify who is at higher risk of recurrence and who may safely skip extra therapy. Learn more: https://bit.ly/SABCS25
#SABCS25 #bcsm