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Alexander Minges

@athemis.bsky.athemis.de

Former structural biologist turned data steward. Cyclist and cat owner/servant. Mastodon: @athemis@nrw.social

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14.01.2025
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Latest posts by Alexander Minges @athemis.bsky.athemis.de

Poster presenting research data management in CRC1430. PDF available: https://doi.org/10.17185/duepublico/84416

Poster presenting research data management in CRC1430. PDF available: https://doi.org/10.17185/duepublico/84416

Presenting #RDM in @crc1430.bsky.social at #TdF2025 @unidue.bsky.social and @ubdue.bsky.social
Poster available: doi.org/10.17185/due...

18.11.2025 11:13 πŸ‘ 1 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0
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Chimeric deubiquitinase engineering reveals structural basis for specific inhibition of the mitophagy regulator USP30 - Nature Structural & Molecular Biology Kazi et al. report the crystal structure of the mitochondrial deubiquitinase USP, a clinical stage Parkinson’s disease drug target, in complex with a specific inhibitor. The authors delineate a framew...

Super happy to share that our work on the specific inhibition of USP30 - a clinical stage Parkinson's drug target - is now online at NSMB www.nature.com/articles/s41... Have a read if you fancy chimeric protein engineering or a framework for DUB ligandability. Huge congratulations to Nafizul & team!

05.05.2025 11:02 πŸ‘ 50 πŸ” 15 πŸ’¬ 4 πŸ“Œ 1
Seminar room with group tables and wall screen reading "Dataverse".

Seminar room with group tables and wall screen reading "Dataverse".

Buffet with salads, fruit and wraps.

Buffet with salads, fruit and wraps.

Grateful for the fantastic #Dataverse upload event of the @crc1430.bsky.social. Many inspiring discussions and a huge pile of datasets for me to work through the next days. Thanks to all participants!

18.03.2025 17:54 πŸ‘ 6 πŸ” 1 πŸ’¬ 1 πŸ“Œ 1
Data Champion: Gina Simon

πŸš€ We’re proud to celebrate Gina Simon, a @crc1430.bsky.social PhD researcher in @hellerschmiedlab.bsky.social at @unidue-zmb.bsky.social, who received the Data Champion Award! Gina shares how eLabFTW streamlines research and boosts efficiency.
#DataChampion #eLabFTW
www.uni-due.de/rds/en/datac...

10.03.2025 09:51 πŸ‘ 5 πŸ” 1 πŸ’¬ 0 πŸ“Œ 2
Your partner for web hosting, servers, domains | netcup Web hosting, servers, domains, e-mails, security, management services - simply everything for your successful internet presence.

Currently using servers from www.netcup.com/en
They offer web hosting (US and European server locations) as well.

06.03.2025 18:03 πŸ‘ 0 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0
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Removal of toxic steroidal glycoalkaloids and bitterness in tomato is controlled by a complex epigenetic and genetic network A complex regulatory network controls the removal of toxic steroidal glycoalkaloids during tomato ripening.

Tomatoes lose their bitterness and toxicity as they ripen thanks to DNA demethylation, the hormone ethylene, and key transcription factors, finds a new #ScienceAdvances study. scim.ag/4bfdr8u

25.02.2025 14:25 πŸ‘ 179 πŸ” 40 πŸ’¬ 4 πŸ“Œ 1
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Many crystal structure analyses that previously required experimental phase evaluation can now be solved by AlphaFold-guided MR. In effect, this and related MR approaches are de novo phasing methods. #MolecularReplacement #MachineLearning doi.org/10.1107/S205...

24.02.2025 14:54 πŸ‘ 4 πŸ” 3 πŸ’¬ 0 πŸ“Œ 0
Developing a dataset for LLM projects - Developing a dataset for LLM projects -

Interested in developing a dataset for a Large Language Models (LLMs) project?

Register for March 5:
www.ebi.ac.uk/training/eve...

Webinar by Melanie Vollmar
(ARISE Fellow working with @pdbeurope.bsky.social team)

From @training.ebi.embl.org's series on:
LLM & Bioinformatics

17.02.2025 13:53 πŸ‘ 5 πŸ” 3 πŸ’¬ 0 πŸ“Œ 0
Transparenz durch Open Data
RKI stellt Daten zur freien Nachnutzung bereit

Transparenz durch Open Data RKI stellt Daten zur freien Nachnutzung bereit

πŸš€ Die Gesundheitsberichterstattung #GBE am #RKI stellt regelmÀßig Daten zu nichtΓΌbertragbaren Krankheiten und ihren Einflussfaktoren auf #GitHub und #Zenodo bereit: maschinenlesbar, offen, frei verwendbar.

πŸ”— www.gbe.rki.de/DE/Startseit...

#OpenData #Gesundheit #Transparenz #PublicHealth

12.02.2025 16:41 πŸ‘ 37 πŸ” 12 πŸ’¬ 0 πŸ“Œ 0
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25.01.2025 07:45 πŸ‘ 185 πŸ” 35 πŸ’¬ 1 πŸ“Œ 7
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Just because it's a homo-oligomer, don't assume it's symmetric! @benjabsnt.bsky.social & collaborators used cryo-EM to study the transthyretin (TTR) tetramer (55 kDa), shedding light on its misfolding pathways linked to amyloid disease. Now in peer-reviewed form: www.nature.com/articles/s41...

22.01.2025 16:45 πŸ‘ 62 πŸ” 17 πŸ’¬ 0 πŸ“Œ 0
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In a great collaboration with @hummerlab.bsky.social and the KrΓ€usslich lab: HIV capsid doesn't break at the NPC; instead, it cracks open the NPC itself! Details in Cell: authors.elsevier.com/sd/article/S... @mpibp.bsky.social @uniheidelberg.bsky.social A thread below:

17.01.2025 18:43 πŸ‘ 429 πŸ” 136 πŸ’¬ 7 πŸ“Œ 22
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PDB-IHM (formerly PDB-Dev) is for integrative structures.

Intergrative structures = from multiple experimental & computational methods.
Since mid-2024 assigned PDB ids & DOIs.

Access via wwPDB archive or
PDB-IHM - pdb-ihm.org

πŸ‘‰ https://www.wwpdb.org/news/news?year=2025#677880ea44a8c95814022eb9

17.01.2025 13:35 πŸ‘ 8 πŸ” 4 πŸ’¬ 0 πŸ“Œ 0

This is just out and already looks like textbook material
#MustRead

16.01.2025 15:38 πŸ‘ 3 πŸ” 2 πŸ’¬ 0 πŸ“Œ 0