Food Allergy Science Initiative

Plot Twist: Food Allergies Might Not Start with Food Skin as Ground Zero: How a Broken Barrier Sparks Food Allergies

Plot Twist: Food Allergies Might Not Start with Food
open.substack.com/pub/theunbia...

Thank you for highlighting this important discovery @snacksafely.bsky.social #foodallergy #immunosky #microbiomesky #medsky #pedsky #science

A graphic showing that interactions between the nervous system and type 2 immunity occur across multiple organs depending on the context of allergic triggers or injury.

In a recent #ScienceImmunology Review, researchers discuss how interactions between the nervous and immune systems could impact neurological disorders and allergy-related behaviors like food avoidance.

Learn more: scim.ag/4mpgzE5

What is the mechanism of food-induced anaphylaxis?
Today @science.org unravelled
www.science.org/doi/full/10....
Gut mast cell leukotriene release
@rmedzhitov.bsky.social

Incredible work by @rmedhitov.bsky.social! We are grateful to support his work and that he guides FASI!

@carlzimmer.com

Funded by @FASI.
Driven by scientists.
Designed to save lives.

Learn more about the research:
🔗 foodallergyscience.org/news-events/...

#FoodAllergy #Anaphylaxis #Science #GutHealth #Immunology

Dr. Stephanie Eisenbarth found that the same molecules make the gut lining leaky—allowing more allergen into the bloodstream.

That leakiness may be what pushes a reaction from uncomfortable… to life-threatening.

Her team also showed Zileuton stopped this leak—and prevented anaphylaxis.

FASI Scientific Founder Dr. Ruslan Medzhitov discovered that special gut cells release leukotrienes—molecules that amplify allergic inflammation.

Block those molecules, stop the cascade.

When mice were treated with the asthma drug Zileuton, they were fully protected from food-induced anaphylaxis.

Why do some allergic reactions turn deadly—while others stay mild?

Two new @science.org papers, funded by @FASI and led by our researchers, uncover the gut–immune connection that may hold the answer. 🧵👇

#FoodAllergy #Anaphylaxis #immunosky #GutHealth #allergysky #medsky #microbiomesky

We are thrilled to have Dr. Nicholas Betley, Assistant Professor of Biology University of Pennsylvania join us at our 2025 Symposium.

Register today: foodallergyscience.org/fasi-symposi...

#immunosky #medsky #allergysky #science

The Global Grants for Gut Health are now open. If your research explores how nutrition affects the gut #microbiome or barrier function, you may be eligible to apply for one of three grants each offering up to USD$100K. Apply here: go.nature.com/4kb9cO1 #Academicsky 🍎📃

Join us on Friday, September 12th, 2025 for FASI’s 2025 Symposium!

To Register and view the agenda, Click Here: foodallergyscience.org/fasi-symposi...

#foodallergy #immunosky #allergysky #medsky

@blackasphodel.bsky.social yes! All of our research into IgE mediated food allergies is applicable to Alpha-Gal.

Big win for early allergen introduction! 🥜🍳👶 New guidelines on introducing allergenic foods to babies have drastically reduced food allergies—from 12% down to just 4% in high-risk infants. #FoodAllergy #PediatricHealth #EarlyFeeding #ParentingTips www.jaci-inpractice.org/article/S221...

Our August issue is out now at www.thelancet.com/gastrohep!

Content includes Crohn’s disease, MASLD, faecal incontinence, variceal bleeding, food allergies, and more…

#GastroSky #LiverSky #MedSky #IBDSky

In the latest ep of the @science.org Podcast I'm joined by researcher Sarita Patil. We talk about how "convergent” antibodies may underlie the growing number of people allergic to peanuts.

www.science.org/content/podc...

We are thrilled to have Dr. Bradford Lowell, Professor of Medicine Beth Israel Deaconess Medical Center join us at our 2025 Symposium on September 12, 2025 at The Broad Institute of MIT and Harvard.

Register today: foodallergyscience.org/fasi-symposi...

#medsky #allergysky #immunosky

Complex chart showing a peanut above the skin layer with S. Aureus bacteria. This triggers a chain of reaction in the skin and in the lymph nodes. When the baby eats the peanut, it triggers the tuft cells and SAP and this eventually causes mast cells to degranulate.

🥜 Food Allergies may start in the Skin, not just the Gut🥜

Damaged skin (as with eczema) can let food proteins in, priming IgE responses that later trigger gut Mast Cells, which drives allergic reactions & anaphylaxis. buff.ly/Nfo06vB

#medsky #pedsky #foodallergy #immunosky 🛟🧪

We are thrilled to have Dr. Ivan de Araujo, FASI Principal Investigator and Director of the Max Planck Institute for Biological Cybernetics join us at our 2025 Symposium on September 12, 2025 at The Broad Institute of MIT and Harvard.

Register today: foodallergyscience.org/fasi-symposi...

We are thrilled to have Dr. Christina Wierenga, Professor of Psychiatry University of California San Diego join us at our 2025 Symposium on September 12, 2025 at The Broad Institute of MIT and Harvard.

Register today: foodallergyscience.org/fasi-symposi...

#immunosky #allergysky #foodallergy

FASI investigator Dr. Sarita Patil examined the structure of antibodies that bind peanut allergens & found a variety of antibodies that can bind peanut allergens!

www.science.org/doi/10.1126/...

#allergysky #pedsky #immunosky #medsky

Photo credit: Monica Fernández-Quintero/Johannes R. Loeffler

Great Research spotlight! One of our FASI funded PIs @danmucida.bsky.social is one of the five papers! Stay tuned as we plan to share more about that work next month!

NICE!

RORγt+ antigen-presenting cells mediate food tolerance - Nature Reviews Immunology Five recent papers identify the RORγt+ antigen-presenting cells that induce food-antigen-specific regulatory T cells and establish food tolerance.

Not one, not two .... but FIVE recent papers highlighting a role for RORgt+ antigen-presenting cells in the gut in establishing tolerance to food antigens
#oraltolerance #immunosky #foodallergy

Our new Immunity paper is in print—and that an oil painting I made was chosen for the cover 😊

It visualizes “affinity birth,” the generative force of SHM creating new antibody specificities beyond V(D)J.

#Immunology #AffinityBirth #SciArt #Bcells #SHM

Amazing!