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Leighton Pritchard

@widdowquinn

Computational biologist. Views/opinions mine, not my employer's. Repost != agreement. Not green, just pleasant. Fabian. =﹥÷ I can’t see DMs because of the Online Safety Act.

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Latest posts by Leighton Pritchard @widdowquinn

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‘I wish I could push ChatGPT off a cliff’: professors scramble to save critical thinking in an age of AI As AI has upended the way students learn, academics worry about the future of the humanities - and society at large

'But in fields most explicitly associated with the production of critical thought – what is collectively referred to as the “humanities”'

That right, aye?

www.theguardian.com/technology/n...

10.03.2026 21:10 👍 1 🔁 1 💬 0 📌 0
Statistical Rethinking 2026 - Lecture B01 - Multilevel Models
Statistical Rethinking 2026 - Lecture B01 - Multilevel Models YouTube video by Richard McElreath

This is the last lecture for the Beginner section. The course plan loops around to lecture B01 (Multilevel Models) from this point and continues to B10. All lectures here: github.com/rmcelreath/s...

10.03.2026 12:41 👍 10 🔁 2 💬 0 📌 1
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Analysis and engineering of quorum sensing-based communications between bacteria and fungi | mBio In natural environments, bacteria and fungi nearly always coexist, and their interactions play pivotal roles in maintaining human health (1, 2) and driving industrial processes (3). In the gut, for in...

Analysis and engineering of quorum sensing-based communications between bacteria and fungi

#mBio MiniReview

journals.asm.org/doi/10.1128/...

10.03.2026 12:45 👍 4 🔁 2 💬 0 📌 0
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Open Science round-up: Making preprints count - International Science Council In this issue, we feature an editorial by the International Network for Advancing Science and Policy (INASP) on how funders and policy-makers can support a faster, more equitable publishing system by ...

"Funders serious about timely, open, and equitable access to research must explicitly recognize preprint sharing as a route to Open Access compliance"

I know I'm a broken record on this but it seems so blindingly obvious... #PlanU journals.plos.org/plosbiology/...

council.science/blog/open-sc...

10.03.2026 13:17 👍 15 🔁 12 💬 0 📌 2
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Welcome! You are invited to join a webinar: ESGEM: Inferring fitness from phylogenies and applications to pathogens. After registering, you will receive a confirmation email about joining the webinar. Speaker: Noémie Lefrancq Chairs: Carla Parada Rodrigues and Francesc Coll I Cerezo

📣 #microsky New ESGEM Webinar @esgem-sg.bsky.social @escmid.bsky.social

Inferring fitness from phylogenies and applications to pathogens

Speaker: Noémie Lefrancq

Chairs: Carla Parada Rodrigues and Francesc Coll I Cerezo

17 March 2026, 12:00 CET

Registration: us06web.zoom.us/webinar/regi...

10.03.2026 13:21 👍 0 🔁 1 💬 0 📌 0
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Gene regulatory networks: from correlative models to causal explanations - Nature Reviews Genetics In this Perspective, Maizels and Briscoe discuss the limitations of current models of gene regulatory networks and outline solutions to harness data abundance without compromising explanatory power.

"GRNs, which should provide mechanistic explanations, are increasingly reduced to statistical correlations — ‘hairballs’ that fail to capture molecular causation"

By Maizels and @jamesbriscoe.bsky.social

www.nature.com/articles/s41...

10.03.2026 13:22 👍 12 🔁 10 💬 2 📌 0

What do you mean I have to publish another paper after I am done with this one. That doesn't sound right. That sounds like a pyramid scheme

10.03.2026 12:23 👍 95 🔁 15 💬 3 📌 2
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Reporting your project’s outcomes The submission period is open from 2 February 2026 until 4pm on 12 March 2026.

Am I unobservant or is there no actual link to ResearchFish on all these pages of advice telling us how important it is to submit outcomes to Researchfish?

www.ukri.org/manage-your-...

10.03.2026 10:18 👍 0 🔁 0 💬 0 📌 0
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The curious section 3 of the new National Security Act A broad and vague provision may be a cause for concern

New at The Empty City

The curious section 3 of the new National Security Act

A broad and vague provision may be a cause for concern -especially for commentators and journalists

Substack version:
emptycity.substack.com/p/the-curiou...

Non-substack version:
theemptycity.com/blog/2026/03...

10.03.2026 09:41 👍 48 🔁 26 💬 2 📌 0
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The bombs and the bombshell: At home in Dubai with Isabel Oakeshott The right wing hack and partner of Reform’s Richard Tice welcomes us into her magnificent war-torn penthouse (note to lawyers: this is satire)

NEW - I had the absolute privilege of interviewing Britain's leading patriot, Isabel Oakeshott, for the New Yorker in Dubai.

Read all about it here:

www.thenewworld.co.uk/henry-morris...

@thenewworldmag.bsky.social

10.03.2026 08:01 👍 158 🔁 43 💬 10 📌 11

It’s Monday. Trump is lying. Iran does not have any Tomahawks. Not one.👇

09.03.2026 23:56 👍 1591 🔁 310 💬 69 📌 9
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Remembering Phil Bourne Personal reflections on a legendary scientist, leader, builder, and mentor

'Phil was also the founding Editor-in-Chief of PLOS Computational Biology, where he created the beloved Ten Simple Rules series. He was so prolific in the series that the meta-article “Ten Simple Rules for Writing a PLOS Ten Simple Rules Article” literally includes, as Rule 4: “Be Philip E. Bourne.”

10.03.2026 04:22 👍 31 🔁 16 💬 1 📌 2

Your regular reminder that almost everything Trump is getting away with is not because of presidential strength, but because of congressional weakness and judicial deference.

The constitutional tools are already there to fix this, but those who can fix it are refusing to do so.

14.04.2025 20:09 👍 6357 🔁 2002 💬 2 📌 3
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Staff at leading Scottish university to strike during graduations over job cut plans UCU members will strike on March 17 and 18, while Unite members will take action between March 16 and 20

www.heraldscotland.com/news/2590026...

"Staff at Strathclyde University will strike during spring graduation ceremonies later this month over plans to cut 76 jobs at the research institution."

10.03.2026 07:47 👍 1 🔁 0 💬 0 📌 0

Quantifying the effects of arbuscular mycorrhizal fungi and potato cyst nematodes on root system architecture using X-ray computed tomography https://www.biorxiv.org/content/10.64898/2026.03.09.710487v1

09.03.2026 18:02 👍 1 🔁 2 💬 0 📌 0
Accessibility score for: evalsp26_01-exam_answers
100% Accessibility score: 100 percent
arrow_drop_up
Perfect!

This PDF has a perfect accessibility score, although further improvements may still be possible. Keep up the good work!

Accessibility score for: evalsp26_01-exam_answers 100% Accessibility score: 100 percent arrow_drop_up Perfect! This PDF has a perfect accessibility score, although further improvements may still be possible. Keep up the good work!

If you use #QuartoPub for any PDF documents for teaching and you need to meet impending PDF accessibility rules, upgrade to v1.9, add format: typst: pdf-standard: ua-1 to the YAML front matter, and it'll work!

09.03.2026 18:26 👍 117 🔁 29 💬 5 📌 6
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Russia targets Signal and WhatsApp accounts in cyber campaign | AIVD Russian state hackers are engaged in a large-scale global cyber campaign to gain access to Signal and WhatsApp accounts belonging to dignitaries, military personnel and civil servants. The Dutch intel...

Don't be afraid to call terrorists terrorists.
Everyone understands which country is doing this.

09.03.2026 16:25 👍 125 🔁 30 💬 6 📌 0

indeed, Bluesky's inherent overall hostility to AI means that the AI enthusiasts still willing to hang out here are usually far smarter and more thoughtful than the absolute dribbling freakshow AI cultists who dominate Twitter/X

09.03.2026 17:26 👍 856 🔁 89 💬 25 📌 1

Let me tell you something. Y’all are asking too many damn questions at every point of sale. I have to leave a comment, make a suggestion, donate to a charity, choose a method of payment three times and then multiple choice of ways to get a receipt.

Take the damn money and leave me alone.

09.03.2026 16:38 👍 3908 🔁 460 💬 65 📌 133

I remain fascinated by people who are 100% all-in on using LLMs at their jobs (and telling everyone that they're doing it) and who appear to have never paused to consider "what value am I personally adding in here, at this point, and why do I think my employers won't eventually figure this out"

09.03.2026 16:43 👍 342 🔁 59 💬 24 📌 4

They aren’t unexpected. They’re the most obvious things you cover in the first 10 minutes of your Iran wargame. This is what makes it worse.

09.03.2026 13:00 👍 115 🔁 24 💬 5 📌 0
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Trump’s Iran Con Put Us in the Covid Before Times Again Trump started an unwinnable war. We know what comes next. We just haven’t felt it yet—the same way we hadn’t truly felt COVID in early March 2020.

The markets crashing may be the first indication to most Americans how badly Trump has fucked up in Iran, the hell he has unleashed for nothing. I compare it to the moment right before the Covid shutdowns. Not because it's a perfect analogy, but because there's no analogy for how bad this can get.

09.03.2026 13:32 👍 78 🔁 18 💬 3 📌 3

Someone on here yesterday pointed out that you can tell they didn’t see any of this coming because they would have done insider trades on the oil futures market if they had.

09.03.2026 12:09 👍 400 🔁 105 💬 8 📌 5
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Peer review reliability is shockingly low. Meta-analyses show reviewer agreement barely above chance, and grant outcomes often depend more on who reviews than what's proposed. Our new preprint with Agnes Urban and Arjun Krishnan @compbiologist.bsky.social : papers.ssrn.com/sol3/papers.... 🧵 1/

09.03.2026 12:55 👍 20 🔁 7 💬 6 📌 2

This is a great post doc opportunity- fantastic system, first-rate science, awesome PI

07.03.2026 13:03 👍 3 🔁 5 💬 0 📌 0

This was the US/UK sponsored coup against PM Mohammad Mosaddegh. The shadow of the coup has hung over Iran ever since. Many of Mosaddegh's followers who'd fled Iran returned in 1979, only to discover the Ayatollahs were no more interested in democracy than the Shah.

en.wikipedia.org/wiki/Mohamma...

08.03.2026 13:57 👍 12 🔁 10 💬 2 📌 0
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Chris Murphy: "I think it's likely the United States that carried out this attack on this school. I think it's unforgivable under any circumstances, but the fact this was one of our first targeting decisions speaks to the incompetence of our leadership at the Dept of Defense."

08.03.2026 13:38 👍 24101 🔁 7414 💬 884 📌 398

The succulent Jordanian medjool dates you get in the supermarket draw on water that fell as rain before 4000 BC.

06.11.2025 14:05 👍 19 🔁 7 💬 1 📌 0
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End of The Line: how Saudi Arabia’s Neom dream unravelled Mohammed bin Salman’s utopian city was undone by the laws of physics and finance

But great to see a detailed piece in @financialtimes.com laying it out. MBS doesn't like to have the truth told about him.

2/2

ig.ft.com/saudi-neom-l...

06.11.2025 09:38 👍 41 🔁 6 💬 5 📌 1
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Neom was never real. This was obvious in July 2023. It's obviouser now

Really good to see the media prepared to tell the truth about Neom. I wrote as long ago as July 2023 that it was more hype than reality - it wasn't going to happen then, it isn't happening now.

1/2

open.substack.com/pub/arthursn...

06.11.2025 09:38 👍 106 🔁 29 💬 6 📌 6