Marcus K.

The Leonardo Apheresis Platform from an Oncology Platform to an Immune Restoration Platform

A closer look at ImmunityBio’s Leonardo platform: CD3/CD14-depleted, IL-12/15/18-primed m-ceNK monotherapy followed by biomarker-guided IL-15 support — and the expansion into iNKT for lymphopenic sepsis.
#CellTherapy #Immunotherapy #NKcells

huggenberg.substack.com/p/the-leonar...

A comprehensive, step-by-step summary of the key steps in Immunotherapy 2.0, highlighting the vital role of IL-15 in transforming standard cancer therapies.
huggenberg.substack.com/p/fundamenta...

01_26_Huggenberg_table_ImmunityBio-Apheresis-Platform.pdf Hoststar Cloud - Your data – any time, any place

Thank you. I would appreciate it if you could also add this reply at the end of the Substack article. Gamma-delta T cells are part of the apheresis platform. I will soon update an article about it on Substack. Here is a link to a PDF.
cloud.hoststar.ch/s/eG8XtDPdET...

The maturation process of lymphocytes and how Anktiva, an IL-15 superagonist, enhances these processes A comprehensive, step-by-step summary of the key processes in Immunology 2.0 and their potential to transform standard cancer care.

Why are lymphocytes often neglected in cancer treatment, and what changes are necessary?
huggenberg.substack.com/p/fundamenta...
#Immunotherapy #PrecisionMedicine #CancerResearch #NKcells #Lymphopenia #CARNK #immunosky

A regulatory pathway to establish a cancer therapy platform based on #Immunotherapy , avoiding #Lymphopenia caused by chemotherapy and radiation, with full patent protection. tinyurl.com/437xrx77
#immunology #PrecisionMedicine #CancerResearch #NKcells #Lymphopenia #CARNK #immunosky

How Natural Killer cell lysate reduces the damage caused by Lymphodepletion in T-cell therapies
#immunosky #medsky #NKcells #Cancer #Cytokines

cloud.hoststar.ch/s/aecHWe5LXS...

rBCG + Anktiva for all cancers?
We know Anktiva enhances BCG’s effectiveness. The combination of rBCG and Anktiva could represent the future of anti-cancer therapies, and rBCG could be integrated into the #CancerBioshield.

#immunology #immunosky

www.cell.com/cms/10.1016/...

Derivation of ImmunityBio's Car-NK strategy
After AI research, a potential strategy for ImmunityBio's future NK-92 and CAR-NK platform can be inferred from several clues provided by three new AACR25 abstract posters.
#CARNK #immunology #NKcell #immunosky
Details:
cloud.hoststar.ch/s/FG546bHA6w...

Recent trends in the incidence of early-onset prostate... : European Journal of Cancer Prevention ), stage at presentation, race/ethnicity, and local treatment patterns. The study encompassed 93 071 cases of EOPC, with the median age at diagnosis being 51 years. From 2000 to 2007, the AAIR of EOPC...

Higher incidence of pancreatic cancer in younger people?
EOPC is defined as a diagnosis occurring before the age of 50.
There is no evidence of an increase in EOPC until 2020 (pre-COVID).
If anybody has any data on EOPC since 2020, he should publish it.
journals.lww.com/eurjcancerpr...

RFK Jr says measles vaccine causes deaths — he's wrong Robert F. Kennedy Jr.'s claim that the measles vaccine causes annual deaths is unfounded. Evidence indicates no deaths from the vaccine.

RFK Jr says measles vaccine causes deaths — he's wrong: "Let’s make this simple — there is no evidence that the measles vaccine causes deaths. There is a ton of evidence that measles itself causes deaths." www.skepticalraptor.com/skepticalrap... via @skepticalraptor.bsky.social

Harriet Hageman got booed to oblivion last night in her own town hall for pumping up Doge so hard that even her loyal suckers woke up and smelled the bullshit—about five months too late!

The end of the genetic paradigm of cancer Genome sequencing results and single-cell transcriptomics continue to produce findings that challenge the idea that cancer is purely a ‘genetic disease’. This Essay delves into cancer omics data that ...

Cancer is a disease of the tissue, not the cell. The end of the genetic paradigm of cancer.
What does this mean for #immunology?

#immunosky

journals.plos.org/plosbiology/...

IL-15: from discovery to FDA approval - Journal of Hematology & Oncology

IL-15: from discovery to FDA approval

IL-15 is the first cytokine in over 30 years to receive FDA approval for the treatment of cancer.

#Immunotherapy #immunology #antibody_fusion_protein #IL-15 #immunosky

jhoonline.biomedcentral.com/articles/10....

Zeihan on Geopolitics: Hear insights on the orchestrated mismanagement of the current US government. This is a tough and long video, but it is worth every second.
www.youtube.com/watch?v=lGFK...

#USSecurity #Ucraine #Russia

The transformation from #cancercare towards #Immunotherapy with a therapeutic #CancerVaccine across multiple tumor types.

#Lymphopenia #antibody_fusion_protein #NKcells

immunitybio.com/founders-vis...

Anktiva as a lymphocyte rescue molecule: Unlocking the power of NK cells and T cells "One way to think about how Anktiva works is it is the first molecule, based on the package insert, that increases and proliferates the NK cells, the T cells, and the CD4+ and CD8+ T cells, without up...

New blood test routine:
Anemia —> Epogen
Neutropenia —> Neupogen
Lymphopenia —> Anktiva
#Immunotherapy #antibody_fusion_protein #NKcells #Lymphopenia #CARNK

#Anktiva mechanism of action

www.urologytimes.com/view/anktiva...

Former blood test routine:
Anemia —> Epogen
Neutropenia —> Neupogen

New blood test routine:
Anemia —> Epogen
Neutropenia —> Neupogen
Lymphopenia —> Anktiva

#Immunotherapy #antibody_fusion_protein #NKcells #Lymphopenia #CARNK

ir.immunitybio.com/news-release...

CAR-mediated targeting of NK cells overcomes tumor immune escape caused by ICAM-1 downregulation - PubMed Downregulation of ICAM-1 on breast cancer cells is a critical escape mechanism from trastuzumab-triggered ADCC. In contrast, CAR-NK cells are able to overcome cancer cell resistance caused by ICAM-1 r...

Study in breast cancer: pubmed.ncbi.nlm.nih.gov/38417916/

Why an AI platform is essential for #Cancercare.

#Immunotherapy #Cancertreatment

www.reddit.com/r/IBRX/comme...

Mr. David Dayen presents a few facts but draws completely incorrect conclusions. Read my first repost.
Anyone interested in understanding Dr. Soon-Shiong should watch his conversation with Dr. Drew:
www.youtube.com/watch?v=5tSR...
#immunology #PrecisionMedicine #Immunotherapy

Mr. David Dayen presents a few facts but draws completely incorrect conclusions because he does not understand the reality surrounding Dr. Patrick Soon-Shiong’s work.
Anyone interested in understanding Dr. Soon-Shiong should watch his conversation with Dr. Drew.
www.youtube.com/watch?v=5tSR...

New HIV Cure Research: Anktiva's 'Kick & Kill' Strategy Explained! YouTube video by ZOOM HOSPITAL

Kick and Kill HIV Cure Strategy: Anktiva (N-803), an IL-15 superagonist, stimulates latent HIV replication in CD4+ cells (the kick) and increases immune cell activation (the kill).
www.youtube.com/watch?v=AfsM...
#immunology #antibody_fusion_protein

Fusion Extension proteins, or how to combine Immunocytokines with Antibodies.
#immunology #bispecific_antibodies #Immunocytokines #Antibodies
www.reddit.com/r/IBRX/comme...

Proof of concept for CAR-NK.
Presentation at the EANO 2024 (European Association of Neuro-Oncology) Congress on October 20th.
Read my take on that trial:
www.reddit.com/r/IBRX/comme...