Nature Cell Biology

An extracellular vesicle-mediated mitochondrial transfer network critical for testosterone synthesis - Nature Cell Biology Xia, Zhang, Peng, Chen et al. find that Leydig cells and macrophages show bidirectional mitochondrial transfer through extracellular vesicles, ensuring Leydig cells have functional mitochondria. The e...

☕Xia, Zhang, Peng, Chen et al. find that #Leydig cells and macrophages show bidirectional mitochondrial transfer through #ExtracellularVesicles, ensuring Leydig cells have functional #mitochondria. The exchange is needed for testosterone production.
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Mitochondria contact lipid droplets through the mitochondrial import complex binding to lipid metabolism enzyme Ayr1 - Nature Cell Biology Heinen et al. show that the mitochondrial import complex recruits lipid droplets to the mitochondrial outer membrane. The mitochondrial import complex binds to the lipid metabolism enzyme Ayr1 and con...

Mitochondria contact lipid droplets through the mitochondrial import complex binding to lipid metabolism enzyme Ayr1
👉https://rdcu.be/e7dRa
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PML targets and resolves structured protein inclusions to mitigate neurodegeneration - Nature Cell Biology Wang et al. show that promyelocytic leukaemia protein (PML) reduces polyG inclusions via chaperone-mediated disaggregation and proteasome-dependent degradation. This suggests a possible role for PML i...

☕Wang et al. show that promyelocytic leukemia protein (PML) reduces polyG inclusions via chaperone-mediated disaggregation and proteasome-dependent degradation. This suggests a possible role for PML in various neurodegenerative diseases.
👉https://rdcu.be/e7dOe
bit.ly/4ucFCy1

LBR and LAP2 mediate heterochromatin tethering to the nuclear periphery to preserve genome homeostasis - Nature Cell Biology Lewis et al. identify lamin B receptor (LBR) and lamina-associated polypeptide 2 (LAP2) as major factors that tether heterochromatin to the envelope. Deletion of these proteins causes changes in 3D ge...

☕ @kutaylab.bsky.social & co identify #lamin B receptor (LBR) and lamina-associated polypeptide 2 (LAP2) as major factors that tether #heterochromatin to the envelope. Deletion of these proteins causes changes in 3D #genome organization, gene expression and cell fate determination.
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Peritumoural adipose tissue drives immune evasion in colorectal cancer via adipose–mesenchymal transformation - Nature Cell Biology Wang, Zheng, Qian, Pan, Tian et al. characterize the crosstalk between peritumoural visceral adipose tissue and colorectal tumour microenvironment and report an immune escape mechanism, which may be p...

☕Wang, Zheng, Qian, Pan, Tian et al. characterize the crosstalk between peritumoral visceral #adipose tissue and colorectal #tumor microenvironment and report an immune escape mechanism, which may be potentially targeted for improved #immunotherapy.
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🍰Read also the News & Views article written by Andrew Hensley & Morgan E. DeSantis:
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☕Dynein–dynactin–cargo adaptor complexes typically function with two dynein motors. Rao et al. show that, under mechanical load, these complexes can recruit a third dynein via a second adaptor, increasing force generation.
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Defining the reference proteomes for small extracellular vesicles and non-vesicular components - Nature Cell Biology Morales-Sanfrutos, Etxeberria-Ugartemendia, Barroso-Gomila and colleagues map the elution profiles of small extracellular vesicles along density gradients from human biofluids and cell lines, distingu...

☕Morales-Sanfrutos, Etxeberria-Ugartemendia, Barroso-Gomila et al map the elution profiles of small #ExtracellularVesicles along density gradients from human biofluids and cell lines, distinguishing extracellular vesicle content from co-isolation components.
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THY1+ cancer stem cells drive metastasis through a pseudohypoxic state shaped by neutrophil-derived mitochondria - Nature Cell Biology Wan, Li, Cao and colleagues report a feedback crosstalk between THY1+ cancer stem cells and neutrophils via migrasome-mediated release of mitochondria, which induces a pseudohypoxic state and promotes...

☕Wan, Li, Cao et al report a feedback crosstalk between THY1+ #cancer #StemCells and neutrophils via #migrasome - mediated release of #mitochondria, which induces a pseudohypoxic state and promotes metastasis.
👉https://rdcu.be/e51HE
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Graphic promoting the Springer Nature “Opening Doors Internship Programme 2026.” The design features bold, colorful abstract shapes in purple, orange, and blue. On the left, logo for “Be part of progress.” On the right, text states “Opening Doors Internship Programme 2026 – Accepting applications,” alongside the Springer Nature logo and the “Stretch Your Horizons” branding. A young woman is seated in the foreground.

Our Opening Doors Internship Programme is open for applications! #BePartOfProgress and join one of our teams to gain hands-on experience working on impactful projects and benefit from the expertise of our talented colleagues.
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#Publishing #WorkInPublishing

Ectosomes step forward in α-synuclein spread - Nature Cell Biology Glucosylceramide accumulation — a hallmark of GBA1- and LRRK2-linked Parkinson’s disease — drives ectosome shedding from neurons. A study now shows that these plasma membrane-derived vesicles shuttle ...

🍰Read also the News & Views article written by Hui Dong, Guicong Zhang & Dan Li:
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Glucosylceramide-induced ectosomes propagate pathogenic α-synuclein in Parkinson’s disease - Nature Cell Biology Jacquemyn et al. identify key lipid determinants controlling ectosome shedding from neurons. They find that ectosomes are a major route for the intercellular transport of misfolded α-synuclein, with r...

☕Jacquemyn et al. identify key #lipid determinants controlling ectosome shedding from #neurons. They find that ectosomes are a major route for the intercellular transport of misfolded α-synuclein, with relevance to #Parkinsons disease pathology.
👉https://rdcu.be/e5k6a
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Motifs and chemistry dictate the role of intrinsically disordered regions - Nature Cell Biology Research shows that the function of intrinsically disordered regions within proteins relies on both linear sequence motifs and broader chemical context, allowing evolution to preserve function without...

🍰Read also the News & Views article written by Yu-Xi Xiao & Alan M. Moses:
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Sequence and chemical specificity define the functional landscape of intrinsically disordered regions - Nature Cell Biology Langstein-Skora, Schmid, Huth et al. propose that intrinsically disordered region functionality can be driven by the interplay between linear binding motifs and contextual chemical characteristics suc...

☕Langstein-Skora, Schmid, Huth et al. propose that intrinsically disordered region functionality can be driven by the interplay between linear binding motifs and contextual chemical characteristics such as charge and hydrophobicity. @alexholehouse.bsky.social
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👋Our February issue is out!
Cover: spatial #transcriptomics

👉Review: telomeric #chromatin
🔬 #mitochondria #mitophagy #senescence #p53 #epigenetics #glioblastoma #IDR #immunotherapy #cGASSTING #apoptosis #lysosomes & more!

www.nature.com/ncb/volumes/...

Tumour acidosis remodels the glycocalyx to control lipid scavenging and ferroptosis - Nature Cell Biology Bång-Rudenstam et al. report that the acidic tumour microenvironment facilitates the assembly of chondroitin sulfate-enriched glycocalyx to disrupt lipid scavenging and prevent ferroptosis, thereby pr...

☕Bång-Rudenstam et al. report that the acidic #tumor microenvironment facilitates the assembly of chondroitin sulfate-enriched glycocalyx to disrupt lipid scavenging and prevent #ferroptosis, thereby providing an adaptive mechanism upon tumor acidosis.
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DOT1L provides transcriptional memory through PRC1.1 antagonism - Nature Cell Biology Neville, Ferguson et al. show that non-canonical Polycomb repressive complex 1.1-mediated gene silencing is antagonized by DOT1L and is required for the therapeutic efficacy of Menin and DOT1L inhibit...

☕Neville, Ferguson et al. show that non-canonical Polycomb repressive complex 1.1-mediated gene silencing is antagonized by DOT1L and is required for the therapeutic efficacy of Menin and DOT1L inhibitors in mixed-lineage leukaemia.
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ER gets out of shape with ageing - Nature Cell Biology The endoplasmic reticulum (ER) is central to protein synthesis, folding and secretion. A study now shows that ageing is characterized by a striking loss of ER mass and remodelling of the ER structure....

🍰Read also the News & Views article written by Kalina Lapenta, Güneş Parlakgül & Ana Paula Arruda:
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ER remodelling is a feature of ageing and depends on ER-phagy - Nature Cell Biology Donahue et al. show that ageing is associated with changes in ER morphology. ER-phagy drives age-associated ER remodelling through tissue-specific factors.

☕Donahue et al. show that #aging is associated with changes in ER morphology. ER-phagy drives age-associated ER remodeling through tissue-specific factors. #autophagy #longevity
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Decoding the proton veil around lysosomes - Nature Cell Biology A newly discovered acidic nanolayer that envelopes lysosomes reveals that proton gradients extend beyond the organelle lumen, identifying a nanoscale regulatory interface that links luminal pH, TMEM17...

🍰Read also the News & Views article written by Massimiliano Stagi:
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DNA nanodevices detect an acidic nanolayer on the lysosomal surface - Nature Cell Biology Tan and colleagues develop DNA nanodevices to detect the pH of the lysosomal outer surface, observing an acidic layer generated by TMEM175 that regulates lysosome positioning in response to changes in...

☕ @zyt0329.bsky.social et al develop DNA nanodevices to detect the pH of the lysosomal outer surface, observing an acidic layer generated by TMEM175 that regulates lysosome positioning in response to changes in juxta-lysosomal pH.
👉https://rdcu.be/e3TPL
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Programmed mitophagy at the oocyte-to-zygote transition promotes lineage endurance - Nature Cell Biology Thendral et al. describe a mitophagic programme that removes deleterious mtDNA during the oocyte-to-zygote transition in Caenorhabditis elegans, promoting mitochondrial health and offspring survival. ...

☕Thendral et al. describe a mitophagic programme that removes deleterious mtDNA during the oocyte-to-zygote transition in C. elegans, promoting #mitochondria health and offspring survival. Loss of this #mitophagy leads to mutant mtDNA accumulation.
👉https://rdcu.be/e3tpJ
bit.ly/4aqi7Zk

RPA exhaustion activates SLFN11 to eliminate cells with heightened replication stress - Nature Cell Biology Stanage et al. identify a role for transfer RNA nuclease SLFN11 in replication-stress-induced cell death in cisplatin-treated cells lacking PrimPol. SLFN11 is activated upon single-stranded DNA accumu...

☕Stanage et al. identify a role for transfer RNA nuclease SLFN11 in replication-stress-induced cell death in cisplatin-treated cells lacking PrimPol. SLFN11 is activated upon single-stranded DNA accumulation at stalled forks followed by replication protein A exhaustion and cell death.
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Metabolic borders shape immune resistance - Nature Cell Biology Spatial organization of the tumour microenvironment is instrumental for tumour progression or sensitivity to therapies. A new study reveals that tumour-associated highly glycolytic SLC2A1+ macrophages...

🍰Read also the News & Views written by Ali Can Savas & Sergei I. Grivennikov:
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SLC2A1+ tumour-associated macrophages spatially control CD8+ T cell function and drive resistance to immunotherapy in non-small-cell lung cancer - Nature Cell Biology Wang, Chu, Chen, Wei and colleagues discover a subset of tumour-associated macrophages expressing SLC2A1 whose spatial proximity to CD8+ T cells drives resistance to anti-PD-L1 treatment in non-small-...

☕Wang, Chu, Chen, Wei et al discover a subset of tumour-associated #macrophages expressing SLC2A1 whose spatial proximity to CD8+ T cells drives resistance to anti-PD-L1 treatment in non-small-cell #LungCancer.
bit.ly/4tCcNLd

A p53-controlled lysosomal recycling circuit fuels phospholipid synthesis - Nature Cell Biology The transcription factor p53 enables phosphoethanolamine scavenging to support increased membrane phospholipid synthesis during senescence. Perturbing lipid synthesis or recycling compromises the fitn...

🍰Read also the Research Briefing here:
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p53 increases phospholipid headgroup scavenging in senescence - Nature Cell Biology Yashinskie, Zhu and colleagues show that p53 activation triggers increased synthesis and accumulation of phospholipids, with enhanced activation of autophagy and lysosomal catabolism programmes and in...

☕Yashinskie, Zhu et al show that #p53 activation triggers increased synthesis and accumulation of phospholipids, with enhanced activation of #autophagy and lysosomal catabolism programmes and increased reliance on lipid headgroup recycling. @lydiafinley.bsky.social
bit.ly/4asbwO3

Want to understand complex intrinsic and extrinsic metabolic regulation of HSCs? Our latest @natcellbio.nature.com review, led by @aysegulerdemm.bsky.social, synthesize insights into cell fate decisions and highlight implications for leukemogenesis. @nickvangastel.bsky.social
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Revealing high-resolution spatial metagenes from spatial transcriptomics - Nature Cell Biology We present SpaHDmap, a deep learning framework that integrates histology images with spatial transcriptomic data to derive high-resolution and interpretable spatial metagenes. We demonstrate that SpaH...

🍰Read also the Research Briefing:
👉https://rdcu.be/e2WzP
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The interpretable multimodal dimension reduction framework SpaHDmap enhances resolution in spatial transcriptomics - Nature Cell Biology Tang, Chen, Qian et al. present a multimodal, interpretable dimension reduction framework called SpaHDmap, which leverages histology images and enhances the resolution of spatial transcriptomics, thus...

☕Tang, Chen, Qian et al. present a multimodal, interpretable dimension reduction framework called SpaHDmap, which leverages #histology images and enhances the resolution of spatial #transcriptomics, thus enabling the dissection of complex tissue structures.
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