This feels like a helpful primer for understanding AI in general. It makes programmers more efficient on the front end because they can generate more code. But it makes them less efficient afterwards because it vastly increases the amount of time they spend tweaking and fixing bugs.
Congrats Brendan, Clif, David, and team! www.nature.com/articles/s41...
1/📢 In our new publication, we estimate that in 2022, 134 million people worldwide had a recent Mycobacterium tuberculosis (Mtb) infection and were at high risk of progressing to TB disease. Read the full paper in PLOS Medicine (tinyurl.com/mtbinfection). #TBSky
Still 2 weeks left to apply for this position.
Such a fun collaboration with @mel-foulon.bsky.social from the TS lab 🤝-👀 We combined dual RNA-Seq 🧬 and advanced imaging 🔬 to uncover how intracellular compartmentalization drives niche-specific metabolic phenotypes in mycobacteria!!
Fantastic team effort ✨
#Tbsky #microsky
pH-responsive substrate switching in mycobacterial Type VII ESX secretion. https://www.biorxiv.org/content/10.64898/2026.02.04.703728v1
Cartoon representing the mycobacterial oxidative phosphorylation system, including cytochromes, NDH-2, and ATP synthase. Taken from Figure 1 of the article.
#Microbiology
The anti-tuberculosis drug bedaquiline targets the mycobacterial ATP synthase, but how that leads to bacterial death is unclear
Here the authors clarify how bedaquiline works
@jnblab.bsky.social @morwan.me
#TBSky #antibiotics #AMR
http://dlvr.it/TQjZ0W
Some bacterial pathogens play dead to dodge antibiotics. A new test watches them closely—and helps choose drugs that finish the job. (Symbolic image: Adobe Stock)
How can we tell whether an antibiotic eradicates an infection? Researchers from the @biomedizin.unibas.ch, at the @unibas.ch, present an antimicrobial single-cell microscopy-based method that measures antibiotic lethality in individual bacteria.
🔗 doi.org/10.1038/s415...
@natmicrobiol.nature.com
Happy to share a new preprint exploring the unusual biochemistry of a "weirdly" diverged cytochrome c in malaria parasites that exemplifies a lineage common to many apicomplexan parasites. @uofubiochem.bsky.social @uuhsresearch.bsky.social @uofutahcihd.bsky.social
www.biorxiv.org/content/10.6...
microphone, pop filter, and interface Never Used Podcast Equipment
did it in four words hemmingway
I can’t believe a technical solution to a complex social problem didn’t work. Ah well, nevertheless
Mycobacterium tuberculosis is an outlier in many ways. One of them is keeping a high degree of functional redundancy despite its obligate pathogen lifestyle. In this review, we reflect on the biological meaning of M. tuberculosis functional redundancies.
journals.plos.org/plospathogen...
1/ A year ago, a 71-year-old Louisiana man died from H5N1, marking the first avian flu death in the US. Now we report in @jem.org that the cause of his death is rogue autoantibodies neutralizing type I IFN (AutoAb-IFN). doi.org/10.1084/jem....
Hey friends. I’m looking for a postdoc interested in studying host-pathogen interactions and immunology of tuberculosis. Send me some good people! We have a great group here! Email me joanne@pitt.edu. Thanks!
If you or someone you know is looking for a post-doctoral position working on mycobacterial envelope biology, please get in touch. I am recruiting here at the University of Western Ontario in London, Ontario, Canada.
Now properly published at @natcomms.nature.com with few additional experiments incl. demonstration of Daptomycin's ability to depolarise non-growing cells.
See the original preprint-thread for a summary of our findings.
www.nature.com/articles/s41...
#microsky
Are you looking for female speakers in CryoEM for seminars and conferences? Are you a woman in CryoEM and not yet on the ‚woman in CryoEM‘ list? Find your speakers and add/update name and affiliation! docs.google.com/spreadsheets...
How does the well tolerated anti-hyperglycemic drug #metformin inhibit mitochondrial complex I?
In our new paper, we use structures, MD and kinetics to show that metformin inhibits by a distinct mechanism that more hydrophobic, less well tolerated, biguanides.
www.nature.com/articles/s41...
The diderm cell envelope is not a stack of layers but a unified scaffold of Inner Membrane–Peptidoglycan–Outer Membrane.
We discuss how tethering the OM to the PG in E. coli preserves integrity — and extend the concept across diderm bacteria.
Curr Opin Microbiol: doi.org/10.1016/j.mi...
#microsky 🔬
Assembly, architecture and functional roles of microbial surface layers www.nature.com/articles/s41... #jcampubs
The panic that kicks in at 2pm every day when I realize it gets dark in two hours
I presented our preclinical work on the BNT164 #Tuberculosis candidates. This work is now also available as a preprint!
www.biorxiv.org/content/10.1...
Still from news coverage of the exploding whale, showing an enormous explosion on a beach
It’s 12 November, so it’s time to mark the 55th anniversary of the exploding whale of Oregon, an attempt to clear a cetacean carcass from a beach which prompted one reporter to say “The blast blasted blubber beyond all believable bounds”
Exciting news! I have two positions open in my lab at the UoManchester: one PDRA and one Research Tech.
Join our team to study evolutionary mycology and help us understand antifungal resistance in fungal pathogens. A fantastic opportunity to join the brilliant Manchester Fungal Infection Group!
Join the LMB's PhD programme! Applications now open for October 2026 Deadline 2nd December 2025
Considering the LMB for your PhD?
We’ve got over 25 projects available, covering a wide array of topics. Check them out here: www2.mrc-lmb.cam.ac.uk/students/int...
Apply by 2nd DEC for Autumn 2026 admission.
Archaeal cells whose DNA has been stained with a blue dye. Zoomed-in images of mutant cells that display chromosome segregation defects.
High-resolution images of DNA-protein complexes obtained with atomic force microscopy. Upon binding, the protein bridges distant sites, forming loops.
📢 Interested in #chromosomes 🧬 & #archaea thriving at the edge of life? PhD project in York,UK on how archaea pass on their genome to daughter cells.Friendly supervisors: me, @steve-quinn-lab.bsky.social & @georgerheath.bsky.social
www.findaphd.com/phds/project...
📅 January 7, 2026
Please RP🙏thx!
A great collaboration with Jukka Corander and colleagues, to define the population structure of this important global pathogen
A first step towards identifying candidate antigens for new improved vaccines...
@tropicalmedicine.ox.ac.uk @wellcometrust.bsky.social
www.nature.com/articles/s41...
PhD opportunity with me and @kshbeckham.bsky.social
www.findaphd.com/phds/project...
Looking for an AMR-themed PhD project? Join us to investigate antibiotic tolerance in Staphylococcus aureus through a fully funded MRC DTP PhD studentship starting in September 2026.
This project is close collaboration with @kateduncan.bsky.social and @mycobacterium-ncl.bsky.social.
