Very proud to share Sam’s work, jointly supervised between @laura-a-vella.bsky.social and my lab. His work exemplifies how to leverage the power of single-cell and spatialomics to uncover new insights into human GC Tfh biology and why studying human immunology matters:

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Multimodal analysis defines GNG4 as a distinguishing feature of germinal center-positioned CD4 T follicular helper cells in humans CD4 T follicular helper (Tfh) cells coordinate humoral immune responses within germinal centers (GC) of lymphoid tissue. Despite their critical roles in vaccination and autoimmunity, the gene expressi...

T follicular helper cells adopt alter egos and localize to diverse niches - what gene expression programs distinguish Tfh in the germinal center? After dissociating tissue samples into single-cell suspension, can we infer which Tfh were positioned in GCs? Check out our new preprint! bit.ly/3XVsrCI