Erik Poppleton

FYI this thread is why the molecular programming feed only has posts from the last 3 days, for the curious 🧬

I’m super happy to pay on a per-feed basis to support the service! It doesn’t make sense for me to set up a whole server with a firehose consumer for my one lil feed that sees a post every ~3 days, so I’m happy to chip in to the economy of scale you have with your consumers and indexers!

This has been an ongoing problem, thankfully, there are lots of drop-in replacements!

leavesubstack.com

Substack’s “Nazi problem” won’t go away after push notification apology Substack may be legitimizing neo-Nazis as "thought leaders," researcher warns.

Just want to throw out there that switching to Substack is probably not the best look for a women’s advocacy organization…

arstechnica.com/tech-policy/...

✨This International Women’s Day, WONDER celebrates the brilliant women pushing the boundaries of discovery in nanotechnology, biotechnology, and research 🧬

From the lab bench to leadership, women are driving innovation, asking bold questions, and transforming ideas into breakthroughs🌎

This album somehow evokes every emotion at the same time, one of my all time favorites.

🤩🤩🤩 such a cool visualization of wobble base pairing 🧬🧪

Exactly. Might be too messy to show the whole anticodon, but the goal would be to show the different binding partners.

Inosine! The art could reflect its multiple binding partners in the tRNA anticodon loop.

A small polymerase ribozyme that can synthesize itself and its complementary strand The emergence of a chemical system capable of self-replication and evolution is a critical event in the origin of life. RNA polymerase ribozymes can replicate RNA, but their large size and structural ...

Ooooh. Cool new paper on origins of life. A simple 45-nucleotide RNA molecule that can perfectly copy itself.

www.science.org/doi/10.1126/...

Also that a lot of people who would otherwise have gone to the US are staying/applying to Europe, increasing, especially, the top of the pool?

Don’t live in the US anymore, but I’m from Utah, where the state bird is the California Seagull, which I never really saw in my neighborhood. You did, however, see them fighting children for their fries at the swimming pool.

The media had the same problems understanding Kendrick Lamar’s performance last year. It was a similar experience of logging into Bluesky and finding thread after thread of people celebrating nuances, references, and subtext in what many media outlets were calling ‘aploticial’

The question everybody is asking: does this method suggest Porifera or Ctenophora as the first branch in the animals?

Dynamic Binder Exchange Improves Protein Labeling Efficiency in DNA‐PAINT up to 15‐Fold Dynamic Binder Exchange (DyBE) leverages transient binder–target interactions to enhance labeling efficiency by up to 15-fold in super-resolution microscopy. DyBE maps nanoscale receptor tyrosine kin...

Up to 15-fold improvement in protein labeling for DNA-PAINT 🧬🔬. We are excited to present our latest work published in @angewandtechemie.bsky.social!
onlinelibrary.wiley.com/doi/10.1002/...

🧪🧬 You can now play Minecraft with DNA nanotechnology! In our latest preprint we introduce DNA polycubes platform: A modeling driven system, where we use SAT-solvers+multiscale simulations to design 3D finite-size structures that assemble in high yield
chemrxiv.org/doi/full/10....

The results are so cool! Congrats to everybody involved!

Uhhhh, don’t turn left?

I moved to Boston and was shocked to discover that left turns are mostly taken by whipping in front of traffic the second the light turns green.

But! Biking was quite possible there because nobody is going anywhere fast, so you just looked drivers in the eyes and dared them to pay your tuition.

Challenge: be normal about Alex Hall
Difficulty: ImpossibHOWDOESHEALWAYSLANDSOCLEAN??? SHOW THESE EUROPEANS THAT THE GREATEST SNOW ON EARTH ALSO MEANS THE GREATEST FLIPS ON EARTH

Screenshot of a Science Magazine headline announcing the retraction of “Integrative phylogenetic positions sponges at the root of the animal tree”

The plot thickens in the sponges-vs-ctenophores-as-animal-outgroup drama…

This is an excellent article on the non-linearities in weaning ourselves off fossil fuels! As the number of extraction/refining/consumption points decrease, the system grows more susceptible to individual failures, which will cause problems unless proactively predicted and protected against.

Yeah, I’m gonna need this.

Structures of mRNA come to life thanks to some innovative use of DNA-PAINT 🧬

Full of courage because they’re no longer invertebrates.

Our paper on the mysterious Devonian organism Prototaxites has now finally been published! See the paper here (www.science.org/doi/10.1126/...) and our explainer thread below!
Prototaxites reconstruction by Matt Humpage

Neat paper! Boosting to the MP feed 🧬

Megan is, in addition to being a brilliant physicist, one of the most gifted communicators about complex topics in our field. Don’t miss our latest edition of the Molpigs podcast!
🧬

Megan is, in addition to being a brilliant physicist, one of the most gifted communicators about complex topics in our field. Don’t miss our latest edition of the Molpigs podcast!
🧬

An interesting discussion on English time-words in the 1600s that I don’t remember being covered in @englishhistpod.bsky.social