Maximilian Kleinert

🚨Paper Alert 🚨: PanK4 Identified as Regulator of Glucose and Lipid #Metabolism. A new study led by mkleinert.bsky.social‬ at our DZD-Partner #DIfE has identified PanK4 as a key regulator of energy metabolism in skeletal muscle. ⬇️ ⬇️ ⬇️ ⬇️

Islet from aged mouse vs islet from young mice after 10 weeks of IF - IHC for Nkx6.1

Today, we report that chronic intermittent fasting impairs beta-cell maturation and function in adolescent mice. Using scRNAseq, we delineated a "maturation score" for beta-cells. Long-term IF good if you're older, might be harmful if you are still developing!
👇
www.cell.com/cell-reports...

Time-resolved effects of short-term overfeeding on energy balance in mice To curb the obesity epidemic, it is imperative that we improve our understanding of the mechanisms controlling fat mass and body weight regulation. While g

Our new paper from @clemmensenc.bsky.social @metabolcenter.bsky.social is available online! I briefly summarize here our findings on the effects of short-term overfeeding in mice! We show real time energy expenditure data during and after overfeeding! diabetesjournals.org/diabetes/art... 🧵 (1/n)

Skeletal muscle ribosome analysis: A comparison of common assay methods and utilization of a novel RiboAb antibody cocktail While total RNA concentrations putatively represent ribosome content, there is a need to homologize various quantification approaches. Thus, total RNA concentrations ([RNA]) provided through UV–Vis s...

Skeletal muscle ribosome analysis: A comparison of common assay methods and utilization of a novel RiboAb antibody cocktail

physoc.onlinelibrary.wiley.com/doi/10.14814...

Shamelessly😬 reposting our recent work to a broader metabolism network—thanks to @frezzalab.bsky.social starter packs. We’d love to hear your thoughts!

Thanks and would be chuffed to be added.

With two complete starter packs (in my profile), here is a 3rd one for the ever-growing metabolism community. Please contact me if you are working (prerequisite) on metabolism and want to be included here; there is still some space. I will keep updating it.

go.bsky.app/7Uwa6fb

Why Is the American Diet So Deadly? A scientist tried to discredit the theory that ultra-processed foods are killing us. Instead, he overturned his own understanding of obesity.

Why Is the American Diet So Deadly?

A scientist tried to discredit the theory that ultra-processed foods are killing us. Instead, he overturned his own understanding of obesity.

@DhruvKhullar

www.newyorker.com/magazine/202...

The cover depicts gut-brain communication as sand in an hourglass, highlighting its circadian component. Cover credits: Cristina Cuesta Martí.

NEW ISSUE! We start 2025 approaching gut-brain crosstalk from a variety of perspectives, including neuroendocrine regulation of gut-brain signaling, interaction between microbiome and circadian rhythms, microbial metabolites associated with gut health and the potential of microbiome-based therapies.

Special Issue: Physiology of ageing skeletal muscle and the protective effects of exercise: The Journal of Physiology: Vol 603, No 1 <em>The Journal of Physiology</em> publishes research in all areas of physiology and pathophysiology that illustrates new physiological principles or mechanisms.

A really nice special issue in @jphysiol.bsky.social by Dr. Chris Sundberg “Physiology of ageing skeletal muscle and the protective effects of exercise” feat. some work by our lab and many others! Check it out @myoblue.bsky.social physoc.onlinelibrary.wiley.com/toc/14697793...

Thanks to all collaborators & funders (a few found here): @andreasmfritzen.bsky.social @lykkesylow.bsky.social @unimelbcmr.bsky.social @dfgpublic.bsky.social @www.helmholtz-munich.de @ismcopenhagen.bsky.social

Pantothenate kinase 4 controls skeletal muscle substrate metabolism - Nature Communications Here, Miranda-Cervantes et al. identified pantothenate kinase 4 (PanK4) as a key regulator of muscle metabolism. Deleting PanK4 impairs fatty acid oxidation and glucose uptake, leading to glucose into...

Curious about muscle metabolism? 🚴‍♂️ We reveal PanK4 as a conserved exercise target in muscle! 💪 PanK4 regulates lipid & glucose use likely via acetyl-CoA. We think PanK4 belongs alongside Akt, mTOR, AMPK, Rac1 & more as a key player in muscle energy homeostasis. #Metabolism #MyoBlue

Thanks for the shout-out! Your 2022 paper was super helpful. Would be fun to find out what these phos sites (T406 and S63) do to PanK4 function, localization, etc...