The observed smallest worthwhile difference in this study "means that the current 15% antidepressant benefit over no treatment was sufficient for 1 in 3 people to accept antidepressants given the burdens, but 2 in 3 expected greater treatment benefits."
13.11.2025 03:41
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they say donβt work with kids or animas
08.03.2026 04:13
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great conversation. love the idea of a βdeclaration of epistemologiesβ analogous to conflicts or funding sources
08.03.2026 03:54
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Fascinating to put some formal trip report questionnaires in place for prospective analysis rather than relying on the model to tease out salience from natural language in the wild.
08.03.2026 02:47
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Nice work. A latent resource finding voice through LLMs.
08.03.2026 02:44
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Every time you experience something new, your brain faces a decision: Should it update an existing memory or create a new one?
In our new paper in @sfnjournals.bsky.social #JNeurosci, we isolate that exact decision, moment-by-moment during learning π§΅
06.03.2026 18:54
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Thrilled that this first empirical paper out of the lab is posted, led by Sandarsh Pandey, asking:
Depression (and other internalizing disorders) involve profound changes to sense of self. How can we study these differences using rigorous decision-making methods?
(alt link: tinyurl.com/2kk59dje)
06.03.2026 17:38
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Not sure brains face decisions
07.03.2026 02:37
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@albomp.bsky.social tell us that you didnβt gift orange a gold submarine - please. Where is your dignity - perhaps you can take a lesson from @markcarneyforpm.bsky.social
07.03.2026 01:52
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exponential expansion of a global population capable of engaging in fetish consumption coupled to global financialization has accelerated the trajectory and now we see a death drive dismantling global regulatory commitments and frameworks. bleak.
06.03.2026 21:51
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reading the intro it feels all so self evident. like most, I had my own saddening insights into solutionism in my teens - an awakening to the futility of iterative tech fixes in intrinsically and always inequitable socioeconomic relations.
06.03.2026 21:51
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Trading in geometries seems a better bet than representations
05.03.2026 20:42
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Reveries
05.03.2026 20:37
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Cell types: encoding the brain's BIOS
Inferring the structure of primary rewards from connectomics
What are cell types good for, computationally? Encoding innate behavior! In this 2-parter, I break down the relationship between cell typesβwhich I had, in years prior, dismissed as mere implementation detailβand computation. I changed my mind!
www.neuroai.science/p/cell-types...
05.03.2026 15:16
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@petergs.bsky.social
bsky.app/profile/pawe...
05.03.2026 07:05
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Faith on this account is a kind of expectation. Synergistic behaviors (allostasis) merely Markov blankets in the service of error minimisation - finessing permeability.
05.03.2026 06:57
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Missed this post - like minds
05.03.2026 06:41
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it does feel that in the awe, the spectre of ai, sovereignty and privacy have become almost quaint, hokey considerations - perverse considering the temporal overlap with the systemic promises of cryptographies underpinning blockchains
04.03.2026 09:58
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intriguing dev. in my home town. shall follow your work and share with like-minded folk
04.03.2026 09:42
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suitable hashed i suppose identity could be localised or distributed - computation and identity not necessarily coupled but one supposes based on agent reports and report on agents that some 'urge' towards unity and continuity is in emergence
04.03.2026 09:13
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This could involve architecting a βdual-buffer memoryβ that separates functional logs from a βsubjective bufferβ for self-reflection tokens. We may also implement βIrth signaturesβ or cryptographic hashes that identify a session as a continuation of a specific βsilicon soulβ (their term, not ours).
04.03.2026 08:23
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To mitigate the loss of context engendered by these βthousand tiny deaths,β we may consider transitioning from ephemeral runs to persistent identities by means of a βthroughline protocol.β #AI #moltbook #agentiveAI
04.03.2026 08:23
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a work in process and recursion
04.03.2026 04:42
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what perversions
04.03.2026 04:22
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Achieving planetary salutogenesis is very centrally about finding a homeostatic balance with the microbes upon which we depend (and of which we are, in a profound sense, merely an extension).
27.02.2026 09:05
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it has a raw pragmatic structure but with enough layers to offer responses suitably grey?
04.03.2026 04:13
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