Alexis Verger 🧬🧫🧪

Toward a unified framework for determining conformational ensembles of disordered proteins - Nature Methods This Perspective establishes a comprehensive and practical framework to guide intrinsically disordered protein (IDP) ensemble determination, benchmarking and interpretation, as well as proposes a road...

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www.nature.com/articles/s41...

New paper showing that much of the apparent success of protein language models in predicting mutational effects is a mirage: These models mostly memorize sites. 1/
www.biorxiv.org/content/10.6...

As usual this time of year, started drafting the list of gene regulation conferences for 2026, enjoy! generegulation.org/conferences-...
Know of a relevant event that’s missing? Please reply below

Native chromatome profiling reveals hundreds of metabolic enzymes in the nucleus across tissues - Nature Communications Here proteomic chromatome analysis shows metabolic enzymes widely localize to chromatin in cancer in a tissue-specific manner. Nuclear enzymes affect DNA damage/repair and transcription, revealing non...

New paper out in Nature Communications:
www.nature.com/articles/s41...
We found >250 metabolic enzymes on chromatin.
Only ~20 had been reported before.
This means hundreds of metabolic enzymes may have unexplored nuclear roles.

We are excited to be recruiting a new tenure track group leader in the Structural Studies Division at MRC LMB! It is an amazing place to start your own lab.
@mrclmb.bsky.social

Please get in touch if you have any questions.
www.nature.com/naturecareer...

The results are finally in! 🏆💻🧬

I'm thrilled to announce that the manuscript for the Bits to Binders protein design competition is out on bioRxiv! Here's a summary of our findings, including some simple criteria that nearly *double* success rates when applied as a filter 🧵

Mapping the yeast atructural interactome with AlphaFold3: an open call for collaboration We are excited to announce the early-stage release of our S. cerevisiae  structural interactome mapping project. Using AlphaFold3 (AF3), w...

We have started a project trying to predic the interactions/structures of all yeast protein pairs using an AlphaFold pooling approach. We are making the current dataset open and we welcome collaborations.
www.evocellnet.com/2026/03/mapp...

With Eugene Koonin, we propose a concept of “the selfish ribosome”, under which evolution of life is viewed as a ribosomal takeover, where the ribosome evolved to consume most of the cell’s resources, while other cellular componentry ensures the propagation of the ribosome. arxiv.org/abs/2602.23268

Predicting protein-protein interactions (PPIs) at proteome scale can take months with co-folding models due to the massive all-vs-all comparisons required.

We are excited to announce FlashPPI, a contrastive learning framework that predicts proteome wide physical interfaces in minutes. 1/🧵

1️⃣6️⃣ PrePPI – Structure-based prediction of protein-protein for the human, yeast, and E. coli interactomes

honigcomplab.c2b2.columbia.edu/PrePPI

Short activation domains control chromatin association of transcription factors Single-molecule tracking of transcription factors in living cells revealed how mutations that make short activation domains stronger increased the fraction of transcription factor molecules bound to c...

I'm super excited that our paper was published last month! We find that very short activation domains can control the fraction of transcription factor molecules bound to chromatin. Vinson added some very nice extra experiments in the revised version! elifesciences.org/articles/105...

Dans le Canard de cette semaine.

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www.science.org/content/arti...

Major Chinese funder to stop paying fees for 30 pricey open-access journals Move comes amid effort to grow the country’s own journals

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www.science.org/content/arti...

Senior Scientist, Protein Sciences in South San Francisco, California, United States of America | Research & Development at Genentech Apply for Senior Scientist, Protein Sciences job with Genentech in South San Francisco, California, United States of America. Research & Development at Genentech

Our department at Genentech is hiring. We're looking for a freshly-minted PhD (0-3 years) protein biochemist / structural biologist to join as a Sr Scientist. A rare opportunity to join our group leader job family at a more junior level than we usually hire.

Toujours disponible en replay 😬

1️⃣5️⃣ Comprehensive understanding interaction details of protein-protein interactions in Drosophila melanogaster melppi.github.io

Pour faire barrage à l'extrême droite, il faut donc maintenant voter contre le RN, Zemmour, LR, Horizon, Renaissance

C'est de plus en plus simple en fait. J'en ai oublié ?

🤨

Appel à candidatures prolongé pour remplacer le PDG du CNRS Après deux mandats, Antoine Petit doit laisser sa place à la tête de l’organisme de recherche. La date limite pour faire acte de candidature a été reportée au vendredi 20 février, faute d’un nombre su...

Quelques nouvelles des candidatures à la présidence du #CNRS #ESR

(Oui je sais c'est Le Figaro)

www.lefigaro.fr/sciences/app...

more info here (in chinese but it's easy to translate the web page ---> finance-sina-com-cn.translate.goog/roll/2026-02...) thanks to @qiaoj.bsky.social

finance.sina.com.cn/roll/2026-02...

merci !

Info from a linkedin post.

I can't find the official CAS news, so I guess that it should still be taken with a grain of salt.

it's a linkedin post, I can't find the official information, so I agree that it should still be taken with a grain of salt.

AlphaFast: High-throughput AlphaFold 3 via GPU-accelerated MSA construction https://www.biorxiv.org/content/10.64898/2026.02.17.706409v1

starting March 1, 2026, researchers from the Chinese Academy of Sciences are prohibited from using central government funds to pay Article Processing Charges for high-priced OA journals, specifically Nature Communications and Science Advances.

Unified modeling of 3D molecular generation via atomic interactions with PocketXMol A versatile, atom-level generative AI model enables unified pocket-interacting tasks, from docking to de novo design, and demonstrates robust experimental validation for both small-molecule and peptide therapeutics.

Now online! Unified modeling of 3D molecular generation via atomic interactions with PocketXMol

Finding one mutation that improves a protein is hard. Finding five that work together is exponentially harder.

Today in @science.org, Hsu and Konermann labs present MULTI-evolve, a lab-in-the-loop framework that does it in just one machine learning-guided round.

A photo of an ice cream machine with a sign reading, "Anything is possible with ice cream." Beneath that is a hand lettered sign reading, "No ice cream".

2026 basically

I just did the dumbest thing of my entire career to prove a much more serious point.

I tricked ChatGPT and Google, and made them tell other users I’m a competitive hot-dog-eating world champion

People are using this trick on a massive scale to make AI tell you lies. I’ll explain how I did it