I had the privilege of hooding two amazing scientists this last weekend. I am certain the best is yet to come for both of them, and I cannot wait to see all their achievements and discoveries in the next chapter of their lives! Congratulations, Dr. Zytnick, and Dr. Govindaraju. Go Bears!
21.05.2025 04:01
👍 5
🔁 0
💬 1
📌 0
#StandUpForScience Berkeley - great turnout and fantastic talks! Science makes sense of the world, saves lives and shapes policy (not the other way around)
07.03.2025 21:15
👍 54
🔁 8
💬 0
📌 0
It is important at this pivotal moment to @standupforscience.bsky.social. Looking forward to sharing my thoughts on why this should be a national priority at tomorrow’s rally in SF:
05.03.2025 16:54
👍 275
🔁 89
💬 2
📌 4
Join
us for the Wind River Conference on Prokaryotic Biology
Consider this conference! It is a great experience for students and postdocs!
wriver.sites.unlv.edu
25.02.2025 21:56
👍 1
🔁 0
💬 0
📌 0
Get in dorks, we're going protesting!
STAND UP FOR SCIENCE WITH US ON MARCH 7TH, 2025
WASHINGTON DC AND EVERY STATE CAPITOL
Because science is for everyone!
Find us at www.standupforscience2025.org
#standupforscience2025 #scienceforall #sciencenotsilence
10.02.2025 23:57
👍 1534
🔁 789
💬 49
📌 84
Metals in Motion: Understanding Labile Metal Pools in Bacteria
Metal ions are essential for all life. In microbial cells, potassium (K+) is the most abundant cation and plays a key role in maintaining osmotic balance. Magnesium (Mg2+) is the dominant divalent cation and is required for nucleic acid structure and as an enzyme cofactor. Microbes typically require the transition metals manganese (Mn), iron (Fe), copper (Cu), and zinc (Zn), although the precise set of metal ions needed to sustain life is variable. Intracellular metal pools can be conceptualized as a chemically complex mixture of rapidly exchanging (labile) ions, complemented by those reservoirs that exchange slowly relative to cell metabolism (sequestered). Labile metal pools are buffered by transient interactions with anionic metabolites and macromolecules, with the ribosome playing a major role. Sequestered metal pools include many metalloproteins, cofactors, and storage depots, with some pools redeployed upon metal depletion. Here, I review the size, composition, and dynamics of intracellular metal pools and highlight the major gaps in understanding.
What do we mean by "labile metal pools"?
Their properties depend primarily on the identity of the cation (are are conserved across species).
This review is part of a special issue dedicated to my post-doc mentor Chris Walsh.
#MicroSky
pubs.acs.org/doi/10.1021/...
06.01.2025 14:53
👍 9
🔁 4
💬 1
📌 0
Two chelators are shown. The ventraö citric acid mojety is highlighted in yellow, the two chelator arms bear either a phenol unit (for MLL) or a 2,3 dihydroxy benzene unit (for RPB B)
#ChemSky This Preprint by @sophieguti.bsky.social has got it all: Natural Product synthesis, Chelators, Ln, Curium luminescence, mass spec methods, bacteria! doi.org/10.26434/che... Comparative Binding Studies of the Chelators Methylolanthanin and Rhodopetrobactin B to Lanthanides and Ferric Iron.🧪🧵
03.12.2024 15:54
👍 38
🔁 11
💬 1
📌 1
Undergrads are presenting their awesome work today in lab meeting! It calls for a rehearsal of Thanksgiving food!
23.11.2024 01:18
👍 2
🔁 0
💬 0
📌 0
could I be added?
13.11.2024 14:44
👍 0
🔁 0
💬 1
📌 0
