Andreas Horn breaks down recent exchanges on the lesion network mapping method.
05.03.2026 11:13
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Andreas Horn breaks down recent exchanges on the lesion network mapping method.
This is a robust response. I particularly liked this figure - clarifying why the original critique showed what it did, and what was missing @foxmdphd.bsky.social
We don't think it invalidates the approach.
We looked into this in our data and replicated the key result showing convergence to non-specific connectome structure. However, our results also suggest there is a practical fix that is already implemented in some LNM studies.
bsky.app/profile/pete...
New preprint: Revisiting the methodological foundation of lesion network mapping.
doi.org/10.64898/202...
A thread.
This is a great response. I love how it emphasizes the importance of reevaluating methods, promotes a collaborative scientific endeavor, and provides analyses (in my mind) sufficiently refuting the main concerns of the initial critique.
A recent paper in @natureportfolio.nature.com raised concerns about the lesion network mapping method. Our team of 16 coauthors analyzed >1000 lesions and 34 symptoms and found that "The methodological foundations of lesion network mapping remain sound" www.biorxiv.org/content/10.6...
A recent @natneuro.nature.com paper analyzed lesion network mapping and raised concerns about the validity of the method.
See below 👇 for our response.
www.biorxiv.org/content/10.6...
🧠⚡ New year, fresh StimBrains talks!
Join us when we explore the brain networks driving schizophrenia & how we can treat them via DBS.
January session (Thurs, Jan 29, noon ET / 6pm CET)
feat. the amazing @andrewpines.bsky.social & Nicola Cascella
✨ Get Zoom link here: talks.stimulatingbrains.org
What is the status of DBS for epilepsy?
Find out in our new review/metaanalysis spearheaded by @laurenahart.bsky.social & Garance Meyer in JNNP: pubmed.ncbi.nlm.nih.gov/40666371/
A 🧵 — please RT for reach! 🙏
Super excited about this!
Activating brain regions linked to reward and positive expectations may be associated with increased antibody responses following vaccination, suggesting a connection between mental states and immune function. doi.org/hbkjfq
Are connectome-based network mapping methods and the >200 papers that have used it invalid?
New paper out in
@NatureNeuro
says YES. nature.com/articles/s41...
I have concerns about this new paper's methods and conclusions, but am biased. What do others think?
New Perspective from myself, Sarah Heilbronner and @myoo.bsky.social . “Rethinking the centrality of brain areas in understanding functional organization” in Nature Neuroscience. 🧵
rdcu.be/eVZ1A
Flyer to join Holmes Lab
The Holmes Lab is #hiring a full-time research assistant/predoc! Our work focuses on functional brain networks-- how they change, how they are impacted in psychiatric illness, and much more!
Please rt and reach out if you’re interested 👀
Find out more holmeslab.rutgers.edu
🚨 New preprint out! 🚨
“Translating the Transcriptome: A Connectomics Approach for Gene-Network Mapping and Clinical Application”
🔗 doi.org/10.1101/2025... 
🧵 A short thread:
1/11 Excited to share our @Naturestudy led by @leonooi.bsky.social @csabaorban.bsky.social @shaoshiz.bsky.social
AI performance is known to scale with logarithm of sample size (Kaplan 2020), but in many domains, sample size can be # participants or # measurements...
doi.org/10.1038/s415...
Alert!!!!
“An Action Networks Model for Pain”
We propose a new model for chronic pain — and highlight two functionally connected cortical networks that could revolutionize how we treat it.
👉 thread below 🧵
osf.io/preprints/ps...
Thrilled our ADHD network mapping work is now out in Annals of the Child Neurology Society, and honored to be featured on the cover!
🔗 Full article: onlinelibrary.wiley.com/doi/full/10....
@childneurosoc.bsky.social @bostonchildrens.bsky.social @simonwarfield.bsky.social @braincircuits.bsky.social
Out now in Brain
A distinct pattern of brain damage intensifies political involvement, regardless of whether you're liberal, conservative, Democrat, or Republican.
With coauthors S.Balters,S. Cohen-Zimerman,G.Zamboni,J.Grafman
academic.oup.com/brain/advanc...
@braincircuits.bsky.social
Mixed Bag #22: Nils Wendel on Learning Psychopharmacology
Wendel explores the topic using a book, a concept, a person, an article, and a surprise item
www.psychiatrymargins.com/p/mixed-bag-...
MR guided focused ultrasound surgery is an effective and uprising treatment option for Essential tremor. But where is the optimal site to sonicate? Which spots to avoid due to side-effects?
@science.org @braincircuits.bsky.social @netstim.org
– a thread🧵!
www.science.org/doi/10.1126/...
The brainstem’s red nucleus is an evolutionarily old structure that emerged as animals began to use limbs for walking, but its function in humans reaches beyond motor control, a new study suggests.
By @sydneywyatt.bsky.social
#neuroskyence
www.thetransmitter.org/brain-imagin...
Rightfully so!
When modeling volumes of tissue activated in subthalamic DBS for clinical outcomes, does it matter whether we process data in native or template space? Julianna Pijar and Clemens Neudorfer say No in the Brain Stimulation Journal:
doi.org/10.1016/j.br...
🧠💊New preprint differentiating antipsychotic medication vs. illness effects on cortical thickness in people w/ psychosis.
Finding: People receiving placebo show prominent cortical thinning over 1st year of illness, whereas those receiving antipsychotics do not. 1/3
www.medrxiv.org/content/10.1...
We’re hiring a clinical research coordinator to lead a neuroimaging study on brain changes across pregnancy and perinatal depression.
wd1.myworkdaysite.com/en-US/recrui...
Please RT.
It was a great honor to talk with the founding editor of Brain Stimulation, Dr. Harold Sackeim!
Beyond the past, present and future of ECT, we covered the entire field of neuromodulation.
Priceless insights from a key leader in the field!
Tune in here 👇
stimulatingbrains.org/71-harold-sa...
Really interesting thread and super cool work!
We had a truly inspiring and insightful conversation with Dr. Rees Cosgrove, Director of Epilepsy and Functional Neurosurgery at @brighamandwomens.bsky.social & Professor of Neurosurgery @harvardmed.bsky.social
Rediscovering the lost art of brain lesions…!
stimulatingbrains.org/70-rees-cosg...
A postdoc in my lab contacted a fellow scientist to get some advice and was told that, because he's currently working on the topic, he "can't give away all his secrets." I find this extremely lame, and yet I keep encountering it. Science is not a zero-sum game!!
