alz-journals.onlinelibrary.wiley.com/doi/10.1002/...
13.03.2026 18:11
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Spatial organization of AQP4 channels in the human brain: links with perfusion, edema, and disease vulnerability | doi.org/10.64898/202...
Aquaporins are a key component of the brain’s glymphatic system. How are they distributed and how do they relate to healthy brain function and dysfunction? ⤵️
I couldn't find a tool to plot different #neuroimaging data in one consistent style, so I made one! Meet yabplot (yet another brain plot) - a #Python package for (sub)cortex & tracts.🧠
- Simple API
- Built-in atlases
- Custom atlas support
🔗 github.com/teanijarv/ya... (drop a ⭐️!)
neuromapr 0.2.1 has been accepted and published on CRAN!
Very excited to get this out to users in the simplest way possible, and hope the #rstats #neuroimaging community finds it useful!
lcbc-uio.github.io/neuromapr/
Lateral hypothalamic input engages a disinhibitory microcircuit in the dorsal raphe to promote behavior activation https://www.biorxiv.org/content/10.64898/2026.02.26.708342v1
🩸 🧠 ⏱️ What if a blood test could predict WHEN an individual would develop symptoms of Alzheimer’s disease? High plasma p-tau217 predicts greater risk for Alzheimer’s symptoms—do the plasma p-tau217 levels provide insights into WHEN symptoms might begin?
nature.com/articles/s41...
Inter-individual variability of neurotransmitter receptor and transporter density in the human brain | doi.org/10.1007/s004...
How do neuroreceptor distributions vary across people?
Pathogenic tau in the mouse locus coeruleus induces noradrenergic hyperactivity and neuropsychiatric phenotypes reminiscent of early Alzheimers disease https://www.biorxiv.org/content/10.64898/2026.01.30.702923v1
New tour de force from @giuliaabaracc.bsky.social. Everything you ever wanted to know about brain signal variability! 🧠 www.nature.com/articles/s41...
The Neuromodulatory Subcortical Systems PIA within @istaart.bsky.social is requesting nominations for the best paper of 2025 on neuromodulatory subcortical systems in Alzheimer's disease!! ISTAART members: promote the work of your colleagues (or yourself) here: alz.surveymonkey.com/r/Publicatio...
Nine subcortical/cerebellar atlases included in the subcortex_visualization Python package (and subcortexVisualizationR package in R). The atlases are depicted in two-dimensional vector graphic format.
The extended version of my thesis procrastination project/subcortex visualization package is out now in both Python and R, now that I’ve graduated 🤠 This figure shows the 9 atlases included (and counting)!
Preprint: www.biorxiv.org/content/10.6...
Website: anniegbryant.github.io/subcortex_vi...
Adolescent Social Isolation Facilitates Tau Spread in Raphe Nuclei Linking Depression and Hyperalgesia in Alzheimers Disease https://www.biorxiv.org/content/10.64898/2026.01.23.701108v1
The Neuromodulatory Subcortical Systems PIA within @istaart.bsky.social is requesting nominations for the best paper of 2025 on neuromodulatory subcortical systems in Alzheimer's disease!! ISTAART members: promote the work of your colleagues (or yourself) here: alz.surveymonkey.com/r/Publicatio...
Excited to share our new preprint! We explore the link between the locus coeruleus (LC) and arousal for astrocytes, pyramidal cells, interneurons in the hippocampus. A fantastic collaboration with @sianduss.bsky.social @bohaceklab.bsky.social, and many others: www.biorxiv.org/content/10.6... 1/5
Reposting this postdoc position, we are still reviewing applications. I will also be at Human Amyloid Imaging from 1/12 till 1/15 and happy to meet.
Thrilled this is out, led by former PD Cameron Ogg (now with her own lab at @rhodescollege.bsky.social!). It was a driven by a desire to see, in real-time, how LC activity/NE release influences downstream targets in behaving animals. SO hard to do, but Cameron did it! www.cell.com/cell-reports...
BOLD signal changes can oppose oxygen metabolism across the human cortex, Nature Neuroscience
fMRI signals “up,” but neural metabolism might be going “down.”
In our @natneuro.nature.com paper, we demonstrate that about 40% of voxels with robust BOLD responses exhibit opposite oxygen metabolism, revealing two distinct hemodynamic modes.
rdcu.be/eUPO8
funds @erc.europa.eu
#neuroskyence 🧵:
This new ERC study uses an overlapping set of human 🧠 donors as our just dropped locus coeruleus preprint. Availability of data from both regions in the same donor facilitates our current efforts to analyze molecular signaling across the circuit, which is highly vulnerable in Alzheimer's disease.
Postdoc position: our team is looking for a postdoctoral colleague interested in developing and testing theories of brainstem function in AD using fMRI/PET. The Martinos Center / MGH in Boston is a superb place to work. Reach out if you have any questions. Come and join us! 🎉🔵
Very proud of our PhD-student Yuliya Patsyuk's first publication: Locus coeruleus-entorhinal cortex tract integrity is linked to plasma tau and GFAP: alz-journals.onlinelibrary.wiley.com/doi/10.1002/...
🔵 🎉
How prediction error drives memory updating: role of locus coeruleus–hippocampal interactions
Looks interesting, from Groves et al
#neuroskyence #psychscisky #cognition
Congrats!!! So great to see Ben working with you Hwamee, and on our favorite research topic!!
Our new review is out today!
𝗧𝗵𝗲 𝗘𝗻𝗲𝗿𝗴𝗲𝘁𝗶𝗰 𝗖𝗼𝗹𝗹𝗮𝗽𝘀𝗲 𝗼𝗳 𝘁𝗵𝗲 𝗔𝗹𝘇𝗵𝗲𝗶𝗺𝗲𝗿’𝘀 𝗕𝗿𝗮𝗶𝗻: 𝗠𝗲𝘁𝗮𝗯𝗼𝗹𝗶𝗰 𝗜𝗻𝗳𝗹𝗲𝘅𝗶𝗯𝗶𝗹𝗶𝘁𝘆 𝗔𝗰𝗿𝗼𝘀𝘀 𝗖𝗲𝗹𝗹𝘀 𝗮𝗻𝗱 𝗡𝗲𝘁𝘄𝗼𝗿𝗸𝘀
We argue that Alzheimer’s disease is not just a problem of brain hypometabolism, but a disorder of metabolic inflexibility.
onlinelibrary.wiley.com/doi/10.1111/...
⚠️ We are hiring a ✨Postdoc✨in Neuroimaging 🧠
Come work with me in the vibrant city of #Toronto! 🌇 Exciting projects related to #Alzheimers disease & vascular brain injury 👩🏻🔬👨🏽🔬🔬
➡️Apply: tinyurl.com/SRIpostdoc
#NowHiring #STEM #phdlife @sunnybrookhsc.bsky.social
➡️Summary:
Just published in Nat. Neurosci.
Led by J.P. Ferrari-Souza, this study used imaging & fluid biomarkers to reveal that microglia modulate Aβ-related astrocyte reactivity, which in turn contributes to AD progression.
@erzimmer.bsky.social
@natureportfolio.nature.com
www.nature.com/articles/s41...
Our paper and research on a #taVNS #MRI setup has now been published: onlinelibrary.wiley.com/doi/10.1111/...
@nbkroemer.bsky.social @glassybrain.bsky.social
Excited to share our newest project using spatial transcriptomics with novel image analysis approaches to investigate the impact of biological risk factors for Alzheimer's disease (AD) - APOE haplotype, sex, and genomic ancestry - on molecular states in the locus coeruleus (LC 🔵) of the human 🧠.
Our paper on CSF, BOLD, pupil, and physiological measures in sleep deprivation and recovery sleep is finally out! 🎉 Congrats Zinong! www.nature.com/articles/s41...
New release of PowerLMM.js! Browser-based power analysis for longitudinal models with dropout.
Now includes:
- Power analysis summary report
- Reproducible & shareable configs (URL/JSON)
- Calculations validated against R
- Hypothesis region visualization
powerlmmjs.rpsychologist.com
New paper in Imaging Neuroscience by Jeanette A. Mumford, Russell A. Poldrack, et al:
Unintended bias in the pursuit of collinearity solutions in fMRI analysis
doi.org/10.1162/IMAG...
