How is pathology changing in the AI age? AI is unlocking potential in clinical diagnosis and performing complex tasks that humans can't—but adoption isn't without challenges.
Sebastian Försch & Inti Zlobec discuss. spkl.io/63325AQc0V
Schematic of the workings of aDBS. In the centre, a patient is depicted with a fully implanted DBS system consisting of electrodes in the subthalamic nucleus and a pulse generator. A magnified DBS electrode is depicted above (real size=1·57 mm in diameter). LFP recordings (in red) are used by the pulse generator to extract a physiomarker. The continuously measured physiomarker acts as feedback signal to control the stimulation. The two different types of aDBS control algorithms—single-threshold and dual-threshold—are depicted on the left. The stimulation amplitude (depicted on the right) changes between a low (A) and high (B) value following a transition time up (C) and down (D), over a period of seconds. A refractory (blanking) period (E) can be chosen, during which the stimulation amplitude cannot change. Copyright: 2025 Published by Elsevier Ltd.
With the introduction of adaptive deep brain stimulation (aDBS) for Parkinson's disease, new questions emerge regarding who, why, and how to treat.
Find out more in a new Therapeutics Review: spkl.io/63328Av8fm
As AI technology becomes more embedded in everyday life, they offer opportunities to address gaps in women’s health, but also pose significant harm when misused.
A @lancetgh.bsky.social Editorial discusses how to safeguard women and girls in the age of AI: spkl.io/63328AxHOA
Figure: 'Inclusive FemTech: what makes it work'. Copyright: Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.
Despite comprising half the global population, women's health remaining a significant blind spot in modern medicine.
A new Viewpoint outlines FemTech, technology-enabled solutions to address the barriers & inequalities in care: spkl.io/63329AatGL
#IWD2026 #InternationalWomensDay
Cover of the Lancet Obstetrics, Gynaecology, & Women’s Health March, 2026, issue.
It’s been 1 year since we launched The Lancet Obstetrics, Gynaecology, & Women’s Health.
This #InternationalWomensDay, explore the journal dedicated to bridging clinical evidence and practice to help transform women’s lives.
Discover more: spkl.io/63323AxuTf
![March 7, 2026 issue of The Lancet. The cover quote: “A staggering 840 million women and adolescent girls worldwide have experienced physical violence, sexual violence, or both […] —a number that has barely changed in the past two decades.”](https://cdn.bsky.app/img/feed_thumbnail/plain/did:plc:ypu6bwefbbzhcvojdj7mz657/bafkreiayfng55flo7g3gzaccabc3qcf4aa337q2xinczha6ofoeg7jlcei)
March 7, 2026 issue of The Lancet. The cover quote: “A staggering 840 million women and adolescent girls worldwide have experienced physical violence, sexual violence, or both […] —a number that has barely changed in the past two decades.”
Getting to zero: what will it take to end violence against women?
More and better data are needed—but enough evidence already exists to invest in bold action at scale.
Read more in our latest issue: spkl.io/63329Axjf7
Cover art for The Lancet Pulse, a new podcast from The Lancet Group. A gradient blue square is overlaid by circles of increasing size, like ripples on a lake.
Introducing The Lancet Pulse—a new podcast translating science into real-world clinical insights.
Editors from The Lancet and leading global experts unpack the hot topics shaping medicine and patient care. spkl.io/63320AQeua
Figure 4: Conservative management for all patients with ADPKD
Autosomal dominant polycystic kidney disease (ADPKD) is the most common genetic cause of chronic kidney disease.
A new Review focuses on current approaches to diagnosis, treatment, and specific aspects of clinical management. Read more: spkl.io/63329AxPWv
Conceptual model of key actors, systems, and drivers of the three major threats to population health.
The three major global threats to population health are non-communicable diseases (#NCDs), infectious disease outbreaks, and environmental degradation.
A Lancet Commission provides a set of priority recommendations to address these threats.
Read now 👉 spkl.io/63328AvBwk
Why does Prof. Rachel Yehuda describe psychedelics as “heart openers”? Why does Dr. Liliana Galindo liken their action to a surgeon’s scalpel?
Find out in a new Lancet Pulse episode 👉 spkl.io/63326AQcFK
Announcing The Lancet Medical Imaging & Theranostics. A new open access journal dedicated to clinical and technological advances in radiology, nuclear medicine, and theranostics. Artwork: Abstract medical image of a torso with vibrant organic shapes and geometric patterns, suggesting medical imaging. Credit: Shonagh Rae.
Introducing our new #goldopenaccess journal on medical imaging and theranostics!
Learn more about the journal’s mission and explore related content from The Lancet Group today: spkl.io/63324As4V2
Register to attend the UCL-Lancet Lecture 2026. Copyright: University College London.
🔍 What does the future hold for global health? Join us at the @ucl.ac.uk Lancet Lecture 2026, where Professor Kanem explores solutions to major health threats of the 21st century. Register here: hubs.ly/Q03_t-6Q0
Research in context panel for Lancet paper "Adult obesity and risk of severe infections: a multicohort study with global burden estimates". Copyright: 2025 The Author(s). Published by Elsevier Ltd. CC BY 4.0.
People with obesity at 70% higher risk of serious infection with one in ten infectious disease deaths globally potentially linked to obesity, study suggests.
Find out more 👉 spkl.io/63326AvBkY
Figure showing an overview of VEXAS syndrome. The clinical phenotype is expanding and the pathobiology of some manifestations have been elucidated. VEXAS=vacuoles, E1 enzyme, X-linked, autoinflammatory, somatic.
VEXAS syndrome is a newly discovered multisystemic disease affecting most organs.
A Review provides a comprehensive overview of VEXAS syndrome, including the disease's discovery, diagnosis, and treatment: spkl.io/63321AvBXS
Alt: Cover art for The Lancet Pulse, a new podcast from The Lancet Group. A blue square is overlaid by circles of increasing size, like ripples on a lake.
Introducing a new Lancet podcast 🎙️
Every month, The Lancet Pulse explores the latest advances and toughest challenges in clinical medicine.
Listen to episodes 0 through 3 today: spkl.io/63320AQeDi
Cover of The Lancet, 28 February 2026 issue. The quote: “The destruction that Kennedy has wrought in 1 year might take generations to repair, and there is little hope for US health and science while he remains at the helm.”
On the cover of The Lancet:
Editorial — “Robert F Kennedy Jr: 1 year of failure”
Read the latest issue: spkl.io/63327Aa31W
Figure showing the effect of statin versus placebo on events listed in statin SmPCs, subdivided by component parts. Results for two outcomes with fewer than ten events are not shown in the figure, but are included in the appendix. FDR=false discovery rate. LFT=liver function test. RBC=red blood cell. RR=rate ratio. SmPC=Summary of Product Characteristics. *FDR significant at the 5% level; RR for results FDR-significant at the 5% level are indicated by black circles and RR for results not FDR-significant at the 5% level indicated by grey circles. †Excluded from FDR testing; RR for results excluded from FDR testing indicated by white circles.
Almost all side effects on statin labels not caused by statins, finds major meta-analysis; authors call for labels to be updated.
Find out more 👉 spkl.io/63329AsNWb
Innovation, challenge, and ethics – in this Lancet Pulse episode, Professor Alexandre Loupy shares the ins and outs of xenotransplantation.
🎙️ spkl.io/63322AQerQ
The Lancet Summit: shaping the future of diabetes prevention. Image credit: Ixefra / Getty Images
📣 Speakers announced!
14 academic and lived experience experts will lead an exceptional programme at The #LancetSummit: shaping the future of #diabetes prevention. Submit your abstract by Jun 12 to join them: hubs.li/Q03MV4_x0
Graph showing use of AI stethoscope examinations (cardiac waveform recordings for AI interpretation) among recruited GP practices in the intervention group (n=96) during the first 12 months of implementation. Stacked bars represent the number of practices (y-axis, left) stratified by usage intensity category: high users (≥31 uses per month), medium users (10–30 uses per month), low users (<10 uses per month), and non-users (0 uses per month). Darker shades within each bar denote higher usage categories, with high users shown in the darkest shade. The overlaid line graph indicates cumulative number of AI stethoscope examinations (y-axis, right) over 12 months, with numbers above each bar denoting the total number of onboarded practices at that timepoint. AI=artificial intelligence. GP=general practitioner.
AI-enabled stethoscopes show promise for improving diagnosis of cardiovascular conditions, UK trial finds.
Explore the research: spkl.io/63326AsjJ8
Figure highlighting proven clinical benefits related to GLP-1 receptor agonists and the GIP–GLP-1 receptor co-agonist tirzepatide in people with type 2 diabetes or obesity. Copyright: 2025 The Author(s). Published by Elsevier Ltd. CC BY 4.0.
Glucagon-like receptor agonists and next-generation incretin-based medications: metabolic, cardiovascular, and renal benefits spkl.io/63327AsNmf
Launching The Lancet Pulse 🚀
From xenotransplantation to psychedelic drug research, The Lancet Pulse translates science into practical insights about new clinical research—and why it matters.
Listen today: spkl.io/63327AvjMX
Timeline of cervical cancer interventions during pregnancy and postpartum. Copyright: 2026 Elsevier Ltd. All rights are reserved.
New Clinical Round—A multidisciplinary management approach to cervical cancer during pregnancy spkl.io/63329Av8nT
Figure showing diagnostic and therapeutic algorithm of leprosy. Copyright: 2025 Elsevier Ltd. All rights are reserved.
Leprosy, or Hansen's disease, remains a key global health issue.
In a Seminar, authors provide an update on key public health and clinical aspects of the disease: spkl.io/63328AQzar
Cover of The Lancet's Feb 21, 2026 issue. Quote on cover reads: Russia's full-scale invasion of Ukraine has been a catastrophe on every level, not least for health. 4 years on, there have been more than 47,000 Ukrainian civilian casualties.
Since the start of the war, 68% of Ukrainians report a decline in their health.
That the situation is not substantially worse is in large part thanks to the determination, adaptability, and courage of the country's health-care workers.
Find out more: tinyurl.com/3we5bck2
Cages for mouse husbandry with individually ventilated caging (IVC) in a laboratory room for research animal husbandry at the University Medical Center Hamburg-Eppendorf. Copyright: Christian Charisius/picture alliance/Getty Images.
Both the UK and US Governments have pledged to end research using animals, but is such a goal
realistic? And how might it change medical research?
✍️ Talha Burki reports: spkl.io/63320AQdTw
"We need to address this crisis head-on to avoid a generational legacy of increased morbidity, mortality, and insecurity."
@sanianishtar.bsky.social calls for coordinated action—a Global Health Leap— to transform & reform the fragmented global health architecture: tinyurl.com/mvzw872t
New online @lancetrh-europe.bsky.social: a personal view of lessons learned during the first year of using the anti-amyloid therapies lecanemab and donanemab at the IRCCS San Raffaele Center for Alzheimer's and Related Diseases in Milan, Italy: www.thelancet.com/journals/lan...
