Nature Reviews Cancer

Re-routing IgE for cancer therapy - Nature Reviews Cancer In a study published in Cell, Xu et al. show that mast cells engineered with tumour-antigen specific antibodies and loaded with an oncolytic virus can be activated by antigen encounter to drive targeted tumour cell killing and amplify local anti-tumour immunity.

#Research Highlight 🚨 Re-routing IgE for cancer therapy:

A recent study reveals that mast cells engineered with tumour-specific antibodies and an oncolytic virus can target and kill tumour cells while boosting local anti-tumour immunity.
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The intestinal microbiota as a key modulator of acute graft-versus-host disease - Nature Reviews Cancer In this Review, Paredes et al. discuss preclinical and clinical evidence suggesting that the intestinal microbiome influences outcomes of allogeneic haematopoietic cell transplantation and, in particular, graft-versus-host disease and propose that microbiota-focused approaches may improve these clinical outcomes.

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Paredes et al. discuss preclinical & clinical evidence suggesting that the intestinal microbiome influences outcomes of allogeneic haematopoietic cell transplantation and, in particular, graft-versus-host disease.

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The intestinal microbiota as a key modulator of acute graft-versus-host disease - Nature Reviews Cancer In this Review, Paredes et al. discuss preclinical and clinical evidence suggesting that the intestinal microbiome influences outcomes of allogeneic haematopoietic cell transplantation and, in particu...

📰 Proud to be featured in Nature Reviews Cancer

The article highlights the growing recognition of microbiota-centered interventions as a promising avenue to improve outcomes in acute GvHD and allo-HCT.

👉 Read the full article: www.nature.com/articles/s41...

@nature.com @natrevcancer.nature.com

Our March issue is live! 🌞 💐

It features articles on:
- Targeting micropinocytosis
- Phagocytosis checkpoints in immunotherapy
- Therapeutic potential of cGAS-STING
- Machine learning & genomics for precision oncology

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http://dlvr.it/TRFWlc

Decoding cancer across scales with metabolomics - Nature Reviews Cancer In this Review, Rowles and Patti present metabolomics workflows to study cancer across scales. They explore the nutrient demands of cancer cells and how those needs can be fulfilled through metabolic interactions within the tumour microenvironment or systemic crosstalk with distant tissues, and discuss the opportunities and challenges of each approach and offer insights into future research directions.

Review🚨
Rowles and Patti decode cancer with #metabolomics across scales. They discuss opportunities and challenges of metabolimics approaches to explore how cancer cells' nutrient demands are met through metabolic interactions in the TME or systemic crosstalk.
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Artificial intelligence-generated synthetic data for cancer research and clinical trials - Nature Reviews Cancer Synthetic data generated by generative artificial intelligence models can serve as a substitute for real patient data. In this Review, Eckardt et al. discuss how synthetic data sets can overcome barriers to data access and sharing, democratize scientific discovery in cancer research, and reduce the costs and failure rates of cancer clinical trials. They also discuss how this will only become possible if we can overcome the challenges of a lack of standardization in training data selection, model evaluation, bias mitigation, privacy preservation and quality assurance.

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Eckhardt et al. highlight the potential of #generativeAI to generate synthetic data that can replace real patient data in cancer research, provided that issues like standardization, bias, privacy, and quality are tackled.
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Inherited resilience - Nature Reviews Cancer Mutant haematopoietic stem cells display broad fitness variation, suggesting that protective mechanisms may limit clonal expansion and malignant transformation. Now, Agarwal et al. identify a germline noncoding variant that confers resilience to clonal haematopoiesis of indeterminate potential (CHIP) by dampening expression of the RNA-binding protein MSI2.

#ResearchHighlight 🚨

Mutant HSCs display broad fitness variation. Now, Agarwal et al. identify a germline noncoding variant that confers resilience to clonal haematopoiesis of indeterminate potential (#CHIP) by dampening expression of the RNA-binding protein MSI2.

So happy to see that the team’s tour de force sparked interest!!! Hope it’s informative and inspires more people to study #agingandcancer

Melissa Dolan
Kendra Libby
Alison Ringel
@vangalenlab.bsky.social

that's awesome! So much effort went into trying to collate such a complex topic into a single review but great to see the resource being utilized! And even still, at the rate new research is coming to light, we are already probably a bit outdated!

Proud of this review on centering models and next gen techs to address and prevent acquired resistance in cancer. Cements the work that our working group within @nciartnet.org has done over the last couple years, glad it resonated with people

Unveiling the molecular and immunological drivers of antibody–drug conjugates in cancer treatment - Nature Reviews Cancer Antibody–drug conjugates are rapidly expanding both in the clinical treatment of cancer and in preclinical development. In this Review, Zippelius et al. highlight the molecular interactions and immune system effects of these sophisticated drugs that drive their efficacy and toxicity.

🥳And coming it at number 1🥁🥁🥁....
Our 1st most downloaded #REVIEW in 2025:

Unveiling the molecular and immunological drivers of antibody–drug conjugates in cancer treatment

#ADCs #antibodydrugconjugates @NatResCancer
#NRCtop10of2025

Targeted protein degradation for cancer therapy - Nature Reviews Cancer Targeted protein degradation (TPD) is an emerging pharmacological modality in cancer therapy. In this Review, Hinterndorfer et al. outline the mechanistic bases of TPD and discuss the characteristics, advantages and applications of established compounds as well as upcoming classes of degraders.

🥳 Our 2nd most downloaded article in 2025:

Targeted protein degradation for cancer therapy

#PROTACs #Degraders @NatResCancer
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Acquired resistance in cancer: towards targeted therapeutic strategies - Nature Reviews Cancer Acquired therapeutic resistance is a key contributor to cancer treatment failure, requiring new approaches to address its complex mechanisms. In this Roadmap, Soragni, Knudsen and colleagues discuss the mechanisms of acquired resistance and the models to better study it. Finally, they promote integration of biomarker-driven strategies and cutting-edge technologies to advance predictive and proactive prevention in cancer therapy.

🥳 Our 3rd most downloaded #REVIEW in 2025:

Acquired resistance in cancer: towards targeted therapeutic strategies

#therapyresistance #cancertherapy @NatResCancer
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Neuro-immune cross-talk in cancer - Nature Reviews Cancer The nervous and immune systems have co-evolved to respond to threats, including cancer. In this Review, Amit et al. outline the reciprocal interactions among neurons, immune cells and tumour cells that regulate peripheral antitumour immune responses and discuss how these mechanisms could be leveraged to enhance immunotherapy.

🥳 Our 4th most downloaded #REVIEW in 2025:

Neuro-immune cross-talk in cancer

#neuroimmune #cancer @NatResCancer
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Cross-priming in cancer immunology and immunotherapy - Nature Reviews Cancer In this Review, Luri-Rey et al. present evidence for the crucial role of conventional type 1 dendritic cells in cross-presenting antigens from other cells via the major histocompatibility complex class I antigen-presenting machinery, which in turn is necessary to prime CD8+ T cells, which then mount efficient immune responses against cancer. The authors also discuss how we can exploit these processes in cancer immunotherapy by increasing the number and/or maturation or activation status of this specialist subtype of antigen-presenting cell.

🥳 Our 5th most downloaded #REVIEW in 2025:

Cross-priming in cancer immunology and immunotherapy
#TME #immunotherapy

@NatResCancer
#NRCtop10of2025

Dendritic cell maturation in cancer - Nature Reviews Cancer Dendritic cells (DCs) shape the adaptive immune response to peripheral tissue antigens and, as such, are crucial for mounting an effective antitumour immune response in cancer. This Review outlines the molecular basis of DC maturation, highlights the mechanisms through which cancer impairs DC maturation and considers the potential for DC-focused cancer immunotherapeutics.

🥳 Our 6th most downloaded #REVIEW in 2025:

Dendritic cell maturation in cancer

#dendriticcells #TME @NatResCancer
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Recent advances in therapeutic cancer vaccines - Nature Reviews Cancer Cancer prevention vaccines have reduced cancer-related mortalities, yet therapeutic cancer vaccine development and clinical translation continues to face challenges. Here, Zaidi, Jaffee and Yarchoan summarize the failures of cancer vaccines of the past, to highlight recent advancements in the field.

🥳 Our 7th most downloaded #REVIEW in 2025:

Recent advances in therapeutic cancer vaccines

#cancervaccines @NatResCancer
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Carboplatin trains macrophages for cardiac defence - Nature Reviews Cancer In a recent Science Immunology paper, He et al. show that treatment with the chemotherapy carboplatin reshapes cardiac-resident macrophage populations, protecting against later heart disease.

In a recent Science Immunology paper, He et al. show that treatment with the chemotherapy carboplatin reshapes cardiac-resident macrophage populations, protecting against later heart disease. Check out this #researchhighlight for more deets! 👇

Genomic and fragmentomic landscapes of cell-free DNA for early cancer detection - Nature Reviews Cancer In this Review, Bruhm et al. provide a comprehensive overview of targeted and genome-wide cell-free DNA detection approaches, examining their potential to complement existing screening programmes or enhance early cancer detection for those cancers without effective screening methods.

🥳 Our 8th most downloaded #REVIEW in 2025:

Genomic and fragmentomic landscapes of cell-free DNA for early cancer detection

#cfDNA #liquidbiopsy @NatResCancer
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On #WorldCancerDay 🎗️💕 , we celebrate being #UnitedByUnique. In this #COMMENT, Mansouri, Zadeh et al. outline a framework to embed patients & the public into basic research, strengthening communication, equity and real‑world impact.

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http://dlvr.it/TQlvx5

The immune microenvironment of colorectal cancer - Nature Reviews Cancer In this Review, Kennel and Greten highlight the role of immune cells in colorectal cancer (CRC) development, progression and metastasis as well as the impact of therapies on the immune microenvironment. They emphasize the need for novel strategies to enhance immunogenicity and CRC patient stratification to improve outcomes.

🥳 Our 9th most downloaded #REVIEW in 2025:

The immune microenvironment of colorectal cancer

#TME #colorectalcancer @NatResCancer
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l-Fucose: a dietary sugar with multifaceted potential in the biology and therapy of cancer - Nature Reviews Cancer The conjugation of glycoproteins and glycolipids with the dietary sugar L-fucose is known as fucosylation. In this Progress article, Bitaraf et al. describe the latest work showing how fucosylation is deregulated in cancer, influencing tumour progression and therapeutic responses, and how it might be leveraged to treat cancer.

🚨 #REVIEW #PROGRESS 🚨

Fucosylation—the attachment of the dietary sugar L‑fucose to glycoproteins & glycolipids—is frequently altered in cancer. Bitaraf et al. outline its role in tumour progression and therapeutic response.

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Ageing, immune fitness and cancer - Nature Reviews Cancer Ageing reshapes immune composition, function and regenerative capacity, with profound effects on tumour immunity, cancer progression and treatment outcomes. In this Review, Dolan and colleagues examine how age-resolved immunoprofiling, insights from ageing haematopoiesis and preclinical modelling are uncovering immune ageing dynamics and therapeutic challenges — revealing new opportunities to optimize cancer therapy across diverse age groups.

🥳 First up in #NRCtop10of2025:

#10) Ageing, immune fitness and cancer

#ageing #aging #ageingandcancer #agingandcancer @NatResCancer
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Get ready...

🚨 Starting Monday, we're counting down the top 10 most downloaded #REVIEW articles of 2025! 🚨

Don't miss it! 🎉

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