Deirdre Logsdon, PhD's Avatar

Deirdre Logsdon, PhD

@deirdrelogsdon

Embryology | Blastoids| Implantation | Trophoblast Development and Function | Infertility | Postdoc | Brumbaugh Lab

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05.12.2024
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Latest posts by Deirdre Logsdon, PhD @deirdrelogsdon

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Pub of the Month! πŸ’œπŸ“°
This research by Dr. Jenna Schmidt and Dr. Lynda Harris demonstrates innovative work on nanoparticles for placenta-specific drug delivery in pregnant nonhuman primates πŸ”¬βœ¨

#PubOfTheMonth #WinRS #ReproRocks #WomenInSTEM #MaternalHealth #Placenta#Science
@lyndakharris.bsky.social

27.02.2026 17:43 πŸ‘ 4 πŸ” 3 πŸ’¬ 0 πŸ“Œ 0
Society for Developmental Biology logo
Society for Developmental Biology 2026 Award Winners

Edwin G. Conklin Medal
Headshot of Lee Niswander
Lee Niswander, University of Colorado Boulder

Society for Developmental Biology Lifetime Achievement Award
Headshot of Alexandra Joyner
Alexandra Joyner, Memorial Sloan Kettering Cancer Center

Viktor Hamburger Outstanding Educator Prize
Headshot of Roberto Mayor
Roberto Mayor, University College London

Elizabeth D. Hay New Investigator Award
Headshot of Jeffrey Farrell
Jeffrey Farrell, National Institutes of Health
 
Society for Developmental Biology Trainee Science Communication Award
Headshot of Nicholas Desnoyer
Nicholas Desnoyer, The Sainsbury Laboratory

Society for Developmental Biology logo Society for Developmental Biology 2026 Award Winners Edwin G. Conklin Medal Headshot of Lee Niswander Lee Niswander, University of Colorado Boulder Society for Developmental Biology Lifetime Achievement Award Headshot of Alexandra Joyner Alexandra Joyner, Memorial Sloan Kettering Cancer Center Viktor Hamburger Outstanding Educator Prize Headshot of Roberto Mayor Roberto Mayor, University College London Elizabeth D. Hay New Investigator Award Headshot of Jeffrey Farrell Jeffrey Farrell, National Institutes of Health Society for Developmental Biology Trainee Science Communication Award Headshot of Nicholas Desnoyer Nicholas Desnoyer, The Sainsbury Laboratory

Congrats to the 2026 SDB Award Winners!
Conklin Medal: Lee Niswander
SDB Lifetime Achievement Award: Alexandra Joyner
Hamburger Outstanding Educator Prize: Roberto Mayor
Hay New Investigator Award: Jeffrey Farrell
SDB Trainee SciComm Award: Nicholas Desnoyer
bit.ly/4afnjiC

05.02.2026 17:34 πŸ‘ 64 πŸ” 27 πŸ’¬ 2 πŸ“Œ 10
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Pub of the Month! πŸ’œπŸ“°

Kicking off January 2026 by celebrating outstanding research in Science Advances, featuring Dr. Yu-Ying Chen’s recent publication from Dr. Humphry Yao’s group at NIEHS.

Cheers to discovery! πŸ”¬βœ¨

#WinRS #WomenInReproductiveSciences

30.01.2026 16:55 πŸ‘ 7 πŸ” 3 πŸ’¬ 0 πŸ“Œ 1
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Pub of the Month! πŸ“„πŸ’œ

This month’s feature: β€œComparative analysis of human and mouse ovaries across age” from the Laird Laboratory @ucsanfrancisco.bsky.social

Celebrating the research (and researchers!) moving science forward. πŸ”¬πŸ₯Όβœ¨

#ReproRocks #WinRS #NewPublication #Research #SSR #Science

31.10.2025 17:59 πŸ‘ 3 πŸ” 2 πŸ’¬ 0 πŸ“Œ 0
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Here’s to unraveling the mysteries of reproduction one (spooky) experiment at a time! πŸ‘»πŸ§ͺ

31.10.2025 18:00 πŸ‘ 3 πŸ” 1 πŸ’¬ 0 πŸ“Œ 0
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Selective RNA sequestration in biomolecular condensates directs cell fate transitions - Nature Biotechnology Stem cell differentiation is controlled by manipulating RNA condensates.

SOOOOO proud of our amazing grad student Mika! πŸ‘ πŸ‘πŸ‘Congrats to
@distefanolab.bsky.social
and @brumbaugh-lab.bsky.social for their manuscript describing how biomolecular condensates direct cell fate!
@natbiotech.nature.com www.nature.com/articles/s41...

28.10.2025 15:38 πŸ‘ 2 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0
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Induction of experimental cell division to generate cells with reduced chromosome ploidy - Nature Communications Researchers induced ploidy reduction in human oocytes generated by somatic cell nuclear transfer, enabling fertilization and embryo development with integrated somatic and sperm chromosomes, highlighting a proof-of-concept for in vitro gametogenesis.

Functional human eggs have been generated from skin cells in a proof-of-concept study in @natcomms.nature.com. The technique could offer a new path to treating infertility, though more research is needed before clinical use.

#devbio

www.nature.com/articles/s41...

01.10.2025 19:17 πŸ‘ 4 πŸ” 1 πŸ’¬ 0 πŸ“Œ 0
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β€˜Congress has your back’: US senators tell scientists they want to protect NIH budget Senate budget bill includes small increase for the health-research agency β€” but faces a long road before being signed into law.

www.nature.com/articles/d41...

04.08.2025 14:31 πŸ‘ 1 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0
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SSR annual meeting was such a blast. Didn’t realize how much I needed my repro friends!
@ssrwinrs.bsky.social
#reprorocks #womeninSTEM

04.08.2025 14:29 πŸ‘ 9 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0
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Going to the SSR annual meeting and need childcare support? Apply for a childcare grant through WinRS! #momsinstem #happymothersday

12.05.2025 17:34 πŸ‘ 4 πŸ” 1 πŸ’¬ 0 πŸ“Œ 0
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Attention SSR Annual Meeting attendees:
Don't miss registration for the Lunch and Learn session with Dr. Kelly Diggs to sharpen up your mentoring skills!
#reprorocks #womeninstem

29.05.2025 20:37 πŸ‘ 5 πŸ” 3 πŸ’¬ 0 πŸ“Œ 0
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Happy Pi Day y’all!

14.03.2025 22:02 πŸ‘ 2 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0
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#womenshistorymonth #womeninstem

04.03.2025 22:16 πŸ‘ 10 πŸ” 2 πŸ’¬ 0 πŸ“Œ 0
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Listen to 2024 Roger V Short Medal Awardee, Dr. Francesca Duncan, discuss ovarian aging and give trainees a bit of her wisdom on the latest SSR podcast! πŸ‘πŸ‘πŸ‘
#womeninSTEM #reprorocks
Listen to the full episode here πŸ‘‡https://www.buzzsprout.com/1786803/episodes/16143433

16.01.2025 16:41 πŸ‘ 7 πŸ” 5 πŸ’¬ 0 πŸ“Œ 0
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H3K36 methylation regulates cell plasticity and regeneration in the intestinal epithelium - Nature Cell Biology Pashos et al. show that H3K36 methylation maintains intestinal epithelial fate commitment, whereas its suppression, which is also observed upon injury, induces a plastic state and expression of genes ...

I’m SO proud of my postdoc lab for publishing their first Brumbaugh Lab paper in @NatureCellBio today! Check out how altered H3K36 methylation impacts intestinal cell plasticity πŸ‘‡
www.nature.com/articles/s41...

Congratulations @Brumbaugh_JB πŸ₯³

09.01.2025 00:11 πŸ‘ 3 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0
Working model of the impact of Slc25a1 deficiency on placental and embryonic cardiac development. In the normal placenta (left), SLC25A1 facilitates the transport of citrate from mitochondria to the cytoplasm. Citrate is converted into acetyl-CoA, which is essential for maintaining H3K27ac and promoting the differentiation of trophoblast cells. Trophoblast cells secrete PSG proteins, supporting normal placental and embryonic heart development. In the absence of Slc25a1 (right), citrate cannot be transported from mitochondria to the cytoplasm, resulting in a reduction in acetyl-CoA levels. This leads to reduced deposition of H3K27ac at the promoter and enhancer regions of key factors involved in trophoblast differentiation and Psg genes, thereby affecting the expression levels of these genes and causing abnormal placental development, which in turn leads to conotruncal defects and thinner ventricular walls in mouse embryonic hearts.

Working model of the impact of Slc25a1 deficiency on placental and embryonic cardiac development. In the normal placenta (left), SLC25A1 facilitates the transport of citrate from mitochondria to the cytoplasm. Citrate is converted into acetyl-CoA, which is essential for maintaining H3K27ac and promoting the differentiation of trophoblast cells. Trophoblast cells secrete PSG proteins, supporting normal placental and embryonic heart development. In the absence of Slc25a1 (right), citrate cannot be transported from mitochondria to the cytoplasm, resulting in a reduction in acetyl-CoA levels. This leads to reduced deposition of H3K27ac at the promoter and enhancer regions of key factors involved in trophoblast differentiation and Psg genes, thereby affecting the expression levels of these genes and causing abnormal placental development, which in turn leads to conotruncal defects and thinner ventricular walls in mouse embryonic hearts.

Wenli Fan et al. leverage conditional mouse knockouts to explore the link between placental problems and congenital heart defects, showing that SLC25A1 regulates trophoblast differentiation and placental development to safeguard embryonic heart formation. πŸ­πŸ«€ https://bit.ly/4g372OU #DevBio

27.11.2024 14:38 πŸ‘ 24 πŸ” 4 πŸ’¬ 1 πŸ“Œ 1