Meg and her Microbes

Happy to share a new publication on Mechanistic Coupling of Enzyme Activities at the Replisome in JBC. We #Traklab compare and contrast strategies used across organisms to coordinate the many enzymatic processes that occur during DNA replication. Hope it is helpful. doi.org/10.1016/j.jb...

Enjoyed presenting and attending some excellent posters yesterday at the #NIH research festival 🤓🥼🧬📊

#Anupamakharelab #NCI #megandhermicrobes #AMR

Protect the integrity of the US National Institutes of Health Letter to the Editor

These members of the NIH Council of Councils are voicing serious concerns about NIH grant terminations, restructure, and budget cuts

go.nature.com/46Vr8t2

PcdA promotes orthogonal division plane selection in Staphylococcus aureus Nature Microbiology - PcdA interacts with DivIVA and FtsZ, promoting Z-ring formation and division plane selection in Staphylococcus aureus, which increases virulence in mice and reduces...

Excited to share that our paper is now out in ⁦Nature Microbiology @natureportfolio.bsky.social! We characterize a positive mechanism for Z ring placement in S. aureus governed by the proteins PcdA/DivIVA, and its implication during infection in a mouse model #Microsky
rdcu.be/dYmdC

We are on the lookout for postdocs for two different projects at the intersection of ecology, evolution, and the human microbiome.

See thread for more information and reach out!

Had a great time this weekend attending the @asa3org.bsky.social 2025 annual meeting, this year in CO! It was an invigorating and refreshing time filled with great workshops, talks, and nature 🏔️. Thankful for this community of like-minded STEM peers ☺️🫶🏼

Had an absolutely fabulous time at the 2025 molecular mechanisms of evolution GRC! Amazing science, amazing people, card games, CanJam, and a lil' EtOH 🥹 - it was a week to remember! Excited to get back into lab this week and put into practice some great suggestions 🤓

Genetic determinants of gene amplifications alter frequency and evolutionary trajectory of antibiotic resistance in Staphylococcus aureus Gene amplifications are thought to be common in bacterial populations, providing a rapid reversible mode of adaptation to diverse stresses, including the acquisition of antibiotic resistance. We previ...

Excited to share this new preprint from the lab, where postdoc Pavan Silva @kptsilva.bsky.social found pathways that control gene amplifications, and thus antibiotic resistance, in Staph aureus!
www.biorxiv.org/content/10.1...

The transfer of antibiotic resistance genes between evolutionarily distant bacteria | mSphere Antibiotic-resistant infections pose a growing threat to global health. This study reveals how genes conferring antibiotic resistance can move between bacteria that belong to different phyla lineages ...

The transfer of antibiotic resistance genes between evolutionarily distant bacteria | mSphere journals.asm.org/doi/10.1128/...

Check out this new review from our lab led by postdoc Pavan Silva! We explore the varied mechanisms by which gene amplifications lead to antibiotic resistance.
www.nature.com/articles/s44...