The American Society for Clinical Investigation

MRE11 deacetylation by SIRT2 promotes DNA binding to facilitate DNA end resection and ATM-dependent signaling

Breast cancer is associated with SIRT2 loss & genomic instability, but the precise mechanism has been unclear

ASCI member David S. Yu & team now show SIRT2 deacetylates MRE11, facilitating DNA binding to promote DNA end resection and ATM-dependent DNA damage signaling: doi.org/10.1172/JCI1...

From ASCI member, Richard M. Weinshilboum & colleagues

Extremely honored to be elected to ASCI (@the-asci.org) member!! Deeply grateful to my current and former lab members, collaborators, colleagues, and mentors—this milestone would not have been possible without you. Proud to work with such an incredible team!

montefioreeinstein.org/news/2026/03...

Is glucagon action altered in steatotic liver disease? doi.org/10.1172/JCI2...

An Editor’s Note by Raghavendra G. Mirmira @rmirmira.bsky.social on Christie et al.: doi.org/10.1172/JCI2...

The pathogenic contribution of PTPN11 mutations to AML has been unclear

John C. Byrd & team reveal PTPN11 mutations in AML can be early events in the clonal evolution of disease development and are associated with variably differentiated myeloid cells: doi.org/10.1172/jci....

Challenging the dogma…

Here, Adrian Vella & team show hepatic resistance to glucagon’s effects on amino acid catabolism is not a significant factor in postprandial metabolism, regardless of obesity or hepatic steatosis: doi.org/10.1172/JCI2...

ASCI Perspectives: Alessia Fornoni, MD, PhD, and MSTP candidate and Antonio M. Fontanella discuss how Fontanella’s experiences as a patient have influenced his path toward becoming a physician-scientist and inform his patient-focused approach to research

Full video: buff.ly/Pxn1o6t

Congratulations to Meeta Prasad Kerlin (Pulmonary, Allergy & Critical Care) on her election to @the-asci.org! Learn more about Dr. Kerlin & her work here➡️ tinyurl.com/2x9vcbsm @pennldi.bsky.social

Congratulations to Edward Lee (@pennpathlabmed.bsky.social) on his election to @the-asci.org! Learn more about Dr. Lee & his work here➡️ tinyurl.com/4fpvejtd @pennaging.bsky.social

Congratulations to @paralkarlab.bsky.social (@penncancer.bsky.social) on his election to @the-asci.org! Learn more about Dr. Paralkar & his work here➡️ tinyurl.com/5xbwrhf9

Congratulations to @romberglab.bsky.social (@chopresearch.bsky.social/ @pennmedicine.bsky.social) on his election to @the-asci.org! Learn more about Dr. Romberg & his work here➡️ tinyurl.com/432m24m9 @i3h-upenn.bsky.social

Dermal fibroblasts respond to IL-4 and IL-13 and promote T cell recruitment in atopic dermatitis

Challenging the idea that fibroblasts are passive bystanders in atopic dermatitis...

ASCI member Richard L. Gallo & team discover dermal fibroblasts respond to IL4 & IL13, producing Ccr3-binding chemokines, & driving T cell recruitment in atopic dermatitis: doi.org/10.1172/JCI1...

Congratulations to Brian Capell (Dermatology) on his election to @the-asci.org! Learn more about Dr. Capell & his work here➡️ tinyurl.com/mpftnypp @pennepigenetics.bsky.social @penncancer.bsky.social

Congratulations to @ahrensnicklas.bsky.social (@chopresearch.bsky.social/ @pennmedicine.bsky.social) on her election to @the-asci.org! Learn more about Dr. Ahrens-Nicklas & her work here➡️ tinyurl.com/msv9skj4

Shaking out the macrophage role in muscle repair

This issue's cover features work by Hiroshi Takayanagi & team on an activin A-producing macrophage subset that aids muscle repair but can trigger abnormal extraskeletal bone formation in a rare disease context: doi.org/10.1172/JCI1...

Congratulations to the 6 @pennmedicine.bsky.social physician-scientists elected to the American Society for Clinical Investigation (@the-asci.org) class of 2026! Please check back as we profile each new member tinyurl.com/4ejz2cnm

Sequencing has aided in the discovery of mutations in inborn errors of immunity, but their clinical relevance is often unclear

ASCI member Altfeld & team @leibnizliv.bsky.social identify a TLR8 mutation causing immune overactivation & inflammation in 2 siblings: doi.org/10.1172/jci....

Another way SARS-CoV-2 cuts through immune defenses

Zoltan Arany & team identify putative host cleavage targets of the SARS-CoV-2 protease 3CLPro, revealing a mechanism by which the virus weakens host innate immunity in individuals with protective OAS1: doi.org/10.1172/jci....

Antiretroviral treatment does not prevent extrapulmonary tuberculosis during SIV/Mtb coinfection in macaques

Does suppression of HIV replication protect against severe Mtb infection?

ASCI member Philana Ling Lin & team report on SIV/ART/TB models, finding antiretroviral treatment reduces pulmonary TB pathology, yet does not prevent extrapulmonary spread of TB: doi.org/10.1172/jci....

Can we identify infections earlier after breast implant reconstruction?

@jphendersonmdphd.bsky.social & team profiled postimplantation drain fluid, revealing an infection-associated molecular signature that substantially pre-dated clinical infection diagnosis: doi.org/10.1172/JCI1...

Fanconi anemia confers a high risk of solid tumors, but there has been a lack of preclinical models.

Here, Grandis et al. generate patient-derived xenograft models for FA head & neck cancer and identify precision medicine therapies based on multi-omic profiling: doi.org/10.1172/JCI1...

Birt-Hogg-Dubé syndrome often features lung cysts, but disease models for this phenotype are lacking

Elizabeth P. Henske & team report mTORC1 hyperactivation in cystic lungs from patients & validate its role in lung cyst formation using a new pre-clinical model: doi.org/10.1172/JCI1...

MET alterations are enriched in lung adenocarcinoma brain metastases, defining a distinct biologic subtype

Non–small cell lung cancer exhibits high rates of brain metastases.

ASCI member Timothy F. Burns (YPSA recipient) & team report MET alterations are enriched in lung adenocarcinoma brain metastases, defining a distinct biologic subtype: doi.org/10.1172/JCI1...

Opening the gates to the blood brain barrier in a high-grade glioma model

Amy B. Heimberger & team find combination the STING agonist 8803 with radiation reprograms the glioma tumor microenvironment, and 8803 induces the opening of the blood-brain barrier: doi.org/10.1172/JCI1...

Join us for ASCI scientific session on March 10th 1-2PM EST:

Dr. Barney S. Graham @msmedu.bsky.social is a thought leader on emerging viral diseases and pandemic preparedness.

Registration: buff.ly/8aotOwA

A target for terminating the long-lived autoimmune response!

ASCI member Maureen A. Su & team find the epigenetic regulator UTX complexes with transcription factors TCF1 & STAT3 to promote pathogenicity of long-lived, stem-like progenitor T cells in T1D models: doi.org/10.1172/JCI1...