Genes & Development (@genesdev)

📽️ G&D Tapes 📽️

G&D Author, Tuo Zhang, tells us about their new study showing how embryonic stem cells attain a diapause-like state, and can maintain their pluripotency and metabolic dormancy.

Read more here:
➡️ https://genesdev.cshlp.org/content/40/5-6/319.full

The Rockefeller University

10.03.2026 18:02 👍 0 🔁 0 💬 0 📌 0

RESEARCH PAPER: Transcriptional derepression of negative regulators of MAP kinase supports maintenance of diapause ES cells in the pluripotent state
By Zhang et al., and Alexander Tarakhovsky
➡️ https://genesdev.cshlp.org/content/40/5-6/319.full

The Rockefeller University
#embryo #stemcell

10.03.2026 15:01 👍 0 🔁 0 💬 0 📌 0

RESEARCH PAPER: Combinatorial use of VHL and KEAP1 PROTACs reveals unexpected synergy and hook effect relief
By Islam et al., and Luca Busino
➡️ https://genesdev.cshlp.org/content/40/5-6/308.abstract

Penn Medicine
#PROTAC #KRAS #cancer #cancertherapy

09.03.2026 18:00 👍 3 🔁 2 💬 0 📌 0

CANCER METABOLISM REVIEW: Metabolic permissiveness: how tissue context shapes cancer
By Chrysanthi Moschandrea and Christian Frezza
➡️ https://genesdev.cshlp.org/content/40/5-6/287.full

Christian Frezza CECAD Cologne Universität zu Köln
#cancermetabolism #tumormicroenvironment

06.03.2026 19:00 👍 0 🔁 0 💬 0 📌 0

🚨 NEW ISSUE ALERT!!! 🚨

New Research articles and Outlook online now at Genes & Development.
Also in this issue, the first in a series of Review articles on Cancer Metabolism.

Click on the link to learn more:
➡️ https://genesdev.cshlp.org/content/40/5-6.toc

05.03.2026 19:00 👍 1 🔁 1 💬 0 📌 0

G&D Editor, Samantha Cyrill, is attending RNA Modifications: Bridging Biological Function & Therapeutic Potential next week in Keystone! #KSRNAMod26 Keystone Symposia

Happy to chat about your work and the journal. Stop by or reach out at cyrill@cshl.edu

For more info:
➡️ https://hubs.la/Q03-NnlC0

05.03.2026 16:00 👍 1 🔁 0 💬 0 📌 0

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OUTLOOK: Making order from disorder in the nucleolus
By Susan J. Baserga @susanbaserga.bsky.social
➡️ https://genesdev.cshlp.org/content/early/2025/12/11/gad.353467.125.abstract

Also read:
➡️ https://genesdev.cshlp.org/content/early/2025/11/26/gad.353180.125.abstract

27.02.2026 19:00 👍 2 🔁 0 💬 0 📌 0

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CANCER METABOLISM REVIEW: Metabolic permissiveness: how tissue context shapes cancer
By Chrysanthi Moschandrea and Christian Frezza
➡️ https://genesdev.cshlp.org/content/early/2026/02/09/gad.353516.125.abstract

#cancermetabolism #oncogene #tumorsuppressor #mutation #TCAcycle

26.02.2026 19:00 👍 0 🔁 0 💬 0 📌 0

🎙️ G&D Voices: Author and Editorial Board Member Maria-Elena Torres-Padilla 🎙️

At G&D, we aim to provide a thoughtful and supportive publishing experience.
Here’s what one author had to say about G&D's editorial process.

Learn more about publishing with G&D here:
➡️ https://genesdev.cshlp.org

25.02.2026 19:00 👍 1 🔁 0 💬 0 📌 0

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RESEARCH PAPER: Independent control of neurogenesis and dorsoventral patterning by NKX2-2
By Jang et al., and Hynek Wichterle
➡️ https://genesdev.cshlp.org/content/early/2026/01/12/gad.352886.125.abstract

#transcriptionfactor #motorneuron #neurogenesis #spinalpatterning #Tinman

24.02.2026 19:00 👍 5 🔁 1 💬 0 📌 0

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RESEARCH PAPER: Retrotransposon activation during spermatogenesis achieves massive ecDNA biogenesis but rare integration
By Tracy, Chen and ZZ Zhao Zhang
➡️ https://genesdev.cshlp.org/content/early/2026/01/22/gad.353011.125.abstract

#retrotransposon #Drosophila #genomestability

23.02.2026 19:00 👍 5 🔁 1 💬 0 📌 0

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RESEARCH PAPER: Transcriptional derepression of negative regulators of MAP kinase supports maintenance of diapause ES cells in the pluripotent state
By Zhang et al., and Alexander Tarakhovsky
➡️ https://genesdev.cshlp.org/content/early/2025/12/11/gad.353143.125.abstract

20.02.2026 19:00 👍 1 🔁 1 💬 0 📌 0

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RESEARCH PAPER: PHA-4/FoxA controls the function of pharyngeal and extrapharyngeal enteric neurons in C. elegans
By Walker et al., and Oliver Hobert
➡️ https://genesdev.cshlp.org/content/early/2025/12/04/gad.353265.125.abstract

Columbia University HHMI
#Celegans #neuron #gut

19.02.2026 19:00 👍 3 🔁 0 💬 0 📌 0

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RESEARCH PAPER: Intrinsically disordered regions stimulate concentration of small nucleolar ribonucleoproteins and formation of Cajal bodies and nucleoli
By Meznad et al., and U. Thomas Meier
➡️ https://genesdev.cshlp.org/content/early/2025/11/26/gad.353180.125.abstract

18.02.2026 19:00 👍 1 🔁 0 💬 0 📌 0

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RESEARCH PAPER: Combinatorial use of VHL and KEAP1 PROTACs reveals unexpected synergy and hook effect relief
By Islam et al., and Luca Busino
➡️ https://genesdev.cshlp.org/content/early/2025/12/08/gad.352916.125.abstract

#PROTAC #KRAS #cancer #cancertherapy

17.02.2026 19:00 👍 3 🔁 1 💬 0 📌 0

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RESEARCH PAPER: Gamete fusion triggers cytosolic functions and P-body recruitment of the RNA-binding protein Mei2 to drive fission yeast zygotic development
By Araoyinbo et al., and Aleksandar Vještica
➡️ https://ow.ly/99UX50Ye5KZ

Ayokunle Araoyinbo @vjesticalab.bsky.social

16.02.2026 19:00 👍 4 🔁 2 💬 0 📌 0

OUTLOOK: Flicking the switch for B cell development
By Ashley Ng and Stephen Nutt
➡️ https://genesdev.cshlp.org/content/40/3-4/143.full

Also read:
➡️ https://genesdev.cshlp.org/content/40/3-4/233.full

WEHI (The Walter and Eliza Hall Institute of Medical Research) University of Melbourne
#Bcell

13.02.2026 19:00 👍 1 🔁 1 💬 0 📌 0

RESEARCH PAPER: Potent synthetic lethality between PLK1 and EYA family inhibitors in tumors of the central and peripheral nervous systems
By Nelson et al., and Hilda Pickett
➡️ https://genesdev.cshlp.org/content/40/3-4/267.full

Children's Medical Research Institute
#cancertherapy #glioblastoma

12.02.2026 19:00 👍 1 🔁 0 💬 0 📌 0

RESEARCH PAPER: B-lineage commitment is dependent on a reversible epigenetic switch
By Tingvall-Gustafsson et al., and Mikael Sigvardsson
➡️ https://genesdev.cshlp.org/content/40/3-4/233.full

Linköping University @lunduniversity.bsky.social
#hematopoiesis #Bcell #transcriptionfactor #epigenetics

11.02.2026 19:00 👍 1 🔁 0 💬 0 📌 0

RESEARCH PAPER: Hunchback functions in the postmitotic larval MDN to restrict axon outgrowth, synapse formation, and backward locomotion
By Lee et al., and Chris Doe
➡️ https://genesdev.cshlp.org/content/40/3-4/255.abstract

HHMI University of Oregon
#neuron #drosophila #locomotion #hunchback

10.02.2026 19:00 👍 3 🔁 0 💬 0 📌 0

RESEARCH PAPER: Plagl1 and Lrrc58 control mammalian body size by triggering target-directed microRNA degradation of miR-322 and miR-503
By LaVigne et al., and Joshua Mendell
➡️ https://genesdev.cshlp.org/content/40/3-4/215.full

Josh Mendell HHMI
#TDMD #RNAdecay #miRNA #triggerRNA #development

09.02.2026 19:00 👍 0 🔁 0 💬 0 📌 0

REVIEW: Nuclear receptor coregulator interactions: beyond the switch
By F. Nafrisha Cassim Bawa and Mitchell Lazar
➡️ https://genesdev.cshlp.org/content/40/3-4/146.full

University of Pennsylvania
#nuclearreceptor #transcription #ligand #coactivator #corepressor

06.02.2026 19:00 👍 1 🔁 0 💬 0 📌 0

RESEARCH PAPER: Mutant p53 binds and controls estrogen receptor activity to drive endocrine resistance in ovarian cancer
By Shao et al., and Maureen Murphy
➡️ https://genesdev.cshlp.org/content/40/3-4/199.full

The Wistar Institute
#ovariancancer #p53 #cancertherapy #endocrineresistance

05.02.2026 19:00 👍 4 🔁 1 💬 0 📌 0

G&D's Editor-In-Chief, Andrew Dillin, will be at the Keystone Symposia on Mitochondria Signaling in Physiology and Disease. #KSMitochondria26

If you’d like to chat about publishing your work with #genesdev, feel free to reach out to dillin@berkeley.edu

05.02.2026 16:02 👍 0 🔁 0 💬 0 📌 0

RESEARCH PAPER: SOX2 phosphorylation during mitosis limits genomic damage
By Williams et al., and Steven Pollard
➡️ https://genesdev.cshlp.org/content/40/3-4/185.full

Edinburgh University
#sox2 #chromatin #neural #mitosis #stemcells #phosphorylation

04.02.2026 19:00 👍 6 🔁 3 💬 0 📌 0

RESEARCH PAPER: ERRγ impedes neuroendocrine prostate cancer development
By Li et al., and Vincent Giguère
➡️ https://genesdev.cshlp.org/content/40/3-4/160.abstract

Vincent Giguère
#prostatecancer #neuroendocrine #cancertherapeutics #nuclearreceptor

03.02.2026 19:31 👍 0 🔁 0 💬 0 📌 0

🚨 NEW ISSUE ALERT!!! 🚨

New Outlook, Review, and Research articles online now at Genes & Development.

Click on the link to learn more:
➡️ https://genesdev.cshlp.org/content/40/3-4.toc

02.02.2026 20:41 👍 4 🔁 1 💬 0 📌 0

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RESEARCH PAPER: Hunchback functions in the post-mitotic larval MDN to restrict axon outgrowth, synapse formation, and backward locomotion
By Lee et al., and Chris Doe
➡️ https://genesdev.cshlp.org/content/early/2025/11/20/gad.353223.125.abstract

#neuron #drosophila #locomotion

30.01.2026 19:00 👍 0 🔁 0 💬 1 📌 1

🎙️ G&D Voices: Author Lori Sussel 🎙️

From submission to publication, our authors’ experiences matter.
Here’s what one of our authors had to say about publishing with G&D.

Learn more about publishing with G&D here:
➡️ https://genesdev.cshlp.org

29.01.2026 21:02 👍 2 🔁 1 💬 0 📌 0

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RESEARCH PAPER: Potent synthetic lethality between PLK1 and EYA family inhibitors in tumors of the central and peripheral nervous systems
By Nelson et al., and Hilda Pickett
➡️https://genesdev.cshlp.org/content/early/2025/11/20/gad.353271.125.abstract

#cancertherapy #glioblastoma

28.01.2026 20:17 👍 0 🔁 0 💬 0 📌 0

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