Kevin Van Bortle

Excited to share our new Nature study! 🧬

We (sidrituruci.bsky.social et al) discovered that CFAP20 helps clear stalled RNAPII, preventing harmful clashes with DNA replication machinery. This protects cells from R-loops and genome instability.

Full paper: www.nature.com/articles/s41...

Check out our latest work on Pol III transcriptome @natcomms.nature.com! We show snaR-A RNA interacts w/ & perturbs splicing in cancer 🤯 Congrats Sihang Zhou for driving a project w/ max. uncertainty, & to co-authors Simon, Sandip, Leela, Ruiying, Rajendra & @kalsotra-lab.bsky.social

rdcu.be/eRIXR

Dysregulated RNA splicing impairs regeneration in alcohol-associated liver disease - Nature Communications Liver regeneration often fails during chronic liver disease. Here, the authors conduct multiomic profiling of human livers to demonstrate that RNA splicing is dysregulated in alcohol-associated liver ...

www.nature.com/articles/s41...

Mechanistic and Epigenetic Partitioning of Lamina-Associated Chromatin Revealed by a Genome-Wide Imaging Screen The nuclear periphery is a key site for heterochromatin organization in eukaryotic cells, where lamina-associated domains (LADs) promote transcriptional repression and genome stability. Despite their ...

🚨New preprint from the lab🚨
🧬 What keeps certain chromatin domains anchored at the nuclear periphery? Our new genome-wide HiDRO screen uncovers a key role for RNA-binding protein hnRNPK.
www.biorxiv.org/content/10.1...

The pioneer transcription factor Zelda controls the exit from regeneration and restoration of patterning in Drosophila The pioneer factor Zelda activates a specific set of developmental and structural genes to end tissue regeneration.

So excited that our latest work is out! We have been working to understand how damaged tissue exits regeneration and returns to normal gene expression, and found a major role for the pioneer transcription factor Zelda in flies. Kudos to @anishbose.bsky.social @keatonschuster.bsky.social et al!

Structural insights into human Pol III transcription initiation in action - Nature Reconstitution of seven human RNA polymerase III (Pol III) transcribing complexes (TC4/5/6/8/10/12/13) halted on U6 promoters with nascent RNAs of 4–13 nucleotides offers molecular insights into Pol I...

Another tour-de-force by the Xu lab #cryoEM

After the Pol II transcribing complexes (www.science.org/doi/10.1126/...), the Pol III transcribing complexes !!!

www.nature.com/articles/s41...

Collage of photos featuring scientists in a biochemistry lab.

New research from the Kalsotra lab provides insight into maturation and specialization of the fetal liver and offers valuable information to the field of regenerative medicine.

Their findings were published in @genesdev.bsky.social

go.mcb.illinois.edu/liver

Congrats, @kalsotra-lab.bsky.social!

Pervasive and programmed nucleosome distortion patterns on single mammalian chromatin fibers We present a genome-scale method to map the single-molecule co-occupancy of structurally distinct nucleosomes, subnucleosomes, and other protein-DNA interactions via long-read high-resolution adenine ...

Amid concerning times, sharing a bit of positivity: our 1st preprint of 2025 (funded VIA NIH COMMON FUND), heroically led by Marty Yang (@martyyang.bsky.social) w/ huge assist from @genophoria.bsky.social lab. Lots to cover so let’s get this tweetorial started (1/n)! www.biorxiv.org/content/10.1...

Kim Lab at UC Irvine Visit the post for more.

Hello Bluesky friends! I am a #newPI starting at UC Irvine in April, interested in gene regulation and functional genomics in stem cell models of development (esp neural crest). We are hiring at all levels – please reach out/spread the word! sskimlab.org

🎇🎄Some holiday reading: Overdue TWEETORIAL on the latest preprint from our lab 🎇🎄

In this work, superstar postdoc @xinhexue.bsky.social combined 2 kinds of pooled CRISPR screens to pinpoint noncoding regulatory elements and the transcription factors that activate these elements.