U Utrecht-CBDD

How are RNAs presented on the cell surface without any transmembrane domains? In our paper published at Molecular Cell @cp-molcell.bsky.social, we provide mechanistic insights into this pressing question. They form ternary complexes with RNA-binding proteins and heparan sulfate proteoglycans.

Tremendous help from Rob de Vries lab @rpdevrieslab.bsky.social and all co-workers!

Chemoenzymatically Synthesized O‐Acetylated GD3 Gangliosides to Examine Viral Receptor Specificities in a Cellular Context 7-O-, 9-O-, and 7,9-di-O-acetylated GD3 gangliosides can be prepared by chemical assembly of a tetrasaccharide as α-glycosyl fluoride that is coupled to sphingosine using a glycosynthase, followed by...

New @angewandtechemie.bsky.social paper jointly supervised by Zeshi Li @lizeshi.bsky.social and Geert-Jan Boons describes the chemoenzymatic synthesis of O-acetylated GD3 as intact glycolipids, and the use there of to study virus binding in cellular context.
onlinelibrary.wiley.com/doi/10.1002/...

Congratulations to CBDD researchers, Geert-Jan Boons and Zeshi Li @lizeshi.bsky.social, and members of #BioBeyond_NL, a consortium co-led by Maastricht, Utrecht, Radboud University and LUMC researchers to advance (glyco)proteomics, glycomics and spatial omics. Read more👇
www.nwo.nl/en/news/nati...

Chemoenzymatic Synthesis of Glycosphingolipids Having an HNK-1 Epitope for Erythrocyte Cell Surface Remodeling Several neuropathies, such as Guillain–Barré syndrome and myelin-associated glycoprotein neuropathy (MAG), are caused by antibodies targeting glycosphingolipids. Several studies have indicated that MA...

New JACS @pubs.acs.org @acs.org paper from the Boons Group, spearheaded by Mehman @complement.bsky.social describes the chemoenzymatic synthesis of intact HNK-1 glycolipids, which were used to glycoengineer erythrocyte surface for binding and lysis assays.

pubs.acs.org/doi/10.1021/...

Great to have almost the entire Bijvoet Centre together for our 2025 Bijvoet Symposium! Looking forward to a lot of exciting science!

Characterization of the glycoproteins of novel fish influenza B-like viruses Novel influenza-like virus sequences previously identified in fish and amphibians were found to cluster as a sister clade of influenza B viruses, but have thus far remained uncharacterized. We demonst...

Happy to be able to contribute to this very cool preprint
Characterization of the glycoproteins of novel fish influenza B-like viruses #glycotime #lovevirology @uu-cbdd.bsky.social www.biorxiv.org/content/10.1...

Proteins are a source of glycans found in preparations of glycoRNA Recent discoveries show that RNA can be modified with sialylated glycans (termed glycoRNA), thus broadening our understanding of cellular glycosylation beyond traditional proteins and lipids. However,...

Excited to share our preprint about proteins that we found in preparations of glycoRNAs now available on bioRxiv! #glycotime (1/9)
www.biorxiv.org/content/10.1...

Another heads-up for the #glycoRNA community from Uni Marburg👇There are many glycoproteins co-isolated with RNA by TRIzol method. They persist throughout RNA sample processing and are not easily degraded by proteinase K. Careful what you are looking at in an RNA blot!

Save the date! #glycotime @uu-cbdd.bsky.social

64 million euros for groundbreaking fundamental research projects | NWO 21 research consortia have the chance to reach a breakthrough thanks to funding from the Open Competition Domain Science - XL. From fundamental research on the effects of certain materials on the meth...

Read the news here: www.nwo.nl/en/news/64-m...

Hello, Bluesky community! Let our first post be a good news: CBDD researchers Geert-Jan Boons and Rob de Vries (@rpdevrieslab.bsky.social), together with researchers in ErasmusMC Rotterdam, were awarded an #ENW-XL from the Dutch Research Council. Stay tuned for #phd/#post-doc openings! #glycotime