JAMA Psychiatry

JAMA Psychiatry presents "Clozapine After 1 Failed Antipsychotic Drug Trial in First-Episode Psychosis: A Randomized Clinical Trial" by Xuan Li, Chang Lu, Zhaolin Zhai, et al. Published March 11, 2026. DOI: 10.1001/jamapsychiatry.2026.0086.

For patients with #FirstEpisodePsychosis unresponsive to initial antipsychotic therapy, clozapine improved symptom response rates and reduced discontinuation due to insufficient efficacy vs olanzapine or amisulpride.

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JAMA Psychiatry presents "Probability, Probability-Based, and Nonprobability Surveys in Psychiatric Epidemiological Research" by Yajuan Si@1, James R. Wagner@1, and Ronald C. Kessler@2. Published online Dec 3, 2025.

📢 This Special Communication recommends hybrid survey designs—combining online panels with probability samples—as a new standard for psychiatric epidemiological research.

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Table 2, "Summary of Meta-Analyses," lists mental disorders (Anxiety, Bipolar, etc.) with outcomes(AMI, ACS, Reinfarction), measures (HR, OR), ES (95% CI), P value, k@number, I2, x², and GRADE certainty (Low, Very low, Moderate).

Systematic review and meta-analysis: #PTSD, depressive, anxiety, and sleep disorders were associated with increased risk of #AcuteCoronarySyndrome, while bipolar and psychotic disorders were not significantly associated. ja.ma/4ssGNI3

Figure 1. Antidepressant Use of the Australian Genetics of Depression Study with two horizontal bar graphs. Graph A shows the number of participants, and Graph B shows the distribution of cumulative prescription duration per antidepressant.

Among adults with #Depression, complex antidepressant treatment patterns were associated with higher polygenic risk for psychiatric traits but not with sustained use of a single antidepressant. ja.ma/3N2Dk3C

A "JAMA Psychiatry" brief report titled "Change Patterns of Posttraumatic and Grief Disorders and Their Somatic Variables in Ongoing Trauma" by Yafit Levin, PhD@1, Menachem Ben-Ezra, PhD@1, Elazar Leshem, PhD@1, et al. Published online November 5, 2025.

Chronic, delayed, and shifting patterns of PTSD, CPTSD, and PGD were linked to higher levels of somatization and pain, highlighting the need for integrated trauma-informed care addressing physical and psychological health. ja.ma/4crr0o7

Table 3 shows unadjusted mortality rates, adjusted HRs for mortality within 2 years of medication initiation for opioid use disorder, by enrollment and MOUD treatment status. Details include person-years, deaths (%), crude rate, and adjusted HR for all-cause and drug/alcohol overdose.

Health plan disenrollment after initiating medications for #OpioidUseDisorder was associated with increased all-cause and overdose mortality compared with remaining enrolled.

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JAMA Psychiatry's 'Climate-Related and Nature-Based Interventions for Mental Health: An Umbrella Review and Meta-Analysis' by Lasse Brandt, MD@1, Michele De Prisco, MD@2, Daniela Nocera, MD@3, et al. Published March 4, 2026.

An umbrella review found #NatureBased interventions yield moderate improvements in tension, fatigue, confusion, and affect, but evidence for climate-related psychosocial interventions remains limited.

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JAMA Psychiatry infographic about a study on yoga for opioid withdrawal. Population: 59 men, aged 18-50, mean age 26. Intervention: 59 participants randomized, 30 yoga add-on therapy, 29 treatment as usual. Findings: YAT group achieved withdrawal text@number times faster. Hazard ratio text@number. Settings: 1 inpatient ward in Bengaluru, India.

Yoga as an adjunct to standard buprenorphine therapy for #OpioidUseDisorder accelerated withdrawal stabilization, improved heart rate variability, and reduced anxiety, sleep latency, and pain compared with standard care alone. ja.ma/4spiJ8O

Table 1. Physical Activity and Sedentary Behavior in Adults With Severe Mental Illness. The table shows, for different disorders(major depressive, bipolar, schizophrenia) the guidelines, risks, sedentary time, and key adverse outcomes.

Among adults with severe mental illness, integrating #PhysicalActivity into psychiatric care improves psychiatric symptoms, cognitive health, and cardiometabolic outcomes, supporting longer life expectancy.

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Diagram outlining GLP-1 therapies and ASUDs. Includes human body illustration showing internal organs like brain, heart, liver, and intestines. Text lists beneficial effects(glucose regulation), open questions(dose/duration), and safety considerations(muscle loss).

#GLP1 receptor agonists demonstrate potential for reducing alcohol and nicotine use in patients, but further randomized studies are required before clinical adoption for addiction. ja.ma/4rPWYPt

Table 3: Mortality rates and adjusted HRs within 2 years of opioid use disorder medication, by enrollment and MOUD treatment status. Data includes person-years, deaths, crude rates per 1000, and adjusted HRs for all-cause & drug/alcohol overdose.

Health plan disenrollment after initiating medications for #OpioidUseDisorder was associated with increased all-cause and overdose mortality compared with remaining enrolled.

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JAMA Psychiatry study on grief therapy for older adults. Population: 20 men, 92 women, mean age 71.58. Intervention: 113 participants, 56 in group GF-CBT, 57 individual. Graph: Grief severity reduced in both formats at 6-month follow-up.

Group grief-focused cognitive behavioral therapy was noninferior to individual therapy for reducing prolonged grief symptoms in older adults, with large symptom reductions in both formats. ja.ma/4r6v9l3

JAMA Psychiatry 'Original Investigation': Climate-Related and Nature-Based Interventions for Mental Health. An Umbrella Review and Meta-Analysis' by Lasse Brandt, MD1,2; Michele De Prisco, MD3,4,5,6; Daniela Nocera, MD7,8,9; et al. Published Online: March 4, 2026.

An umbrella review found #NatureBased interventions yield moderate improvements in tension, fatigue, confusion, and affect, but evidence for climate-related psychosocial interventions remains limited.

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Two bar graphs compare changes in CES-D scores. Graph A, "Causal forest model," shows SBMT having d=0.07, P=.007, and TAU having d=-0.01, P=.82. Graph B, "Elastic net regression model," shows SBMT having d=0.08, P=.004, and TAU having d=0, P>.99.

Machine learning analyses in the MYRIAD trial found only clinically trivial personalization of school-based mindfulness for adolescent #Depression prevention, underscoring limited differential benefit in universal programs.

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JAMA Psychiatry article, "Brain and Blood Biomarkers of Major Depressive Disorder: A Systematic Review" by Lia J. Zallar, PhD@1,2 and Maura B. Dupont, MD, PhD@1,2. Published Online: February 25, 2026. doi: 10.1001/jamapsychiatry.2025.4613.

In #MajorDepressiveDisorder, shared brain and blood biomarkers indicate disrupted mitochondrial metabolism, neurodevelopment, inflammation, transcription, and apoptotic pathways, highlighting potential biomarker and treatment targets.

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Fig 5: Spatial Correlations of Neurotransmitters With Biotype-Specific Deviations. Three radar charts labelled Biotype 1, Biotype 2, Biotype 3 each plot neurotransmitter spatial correlations around a central point from -0.4 to 0.4.

Normative modeling of morphometric similarity networks in #ADHD identified three distinct biotypes with unique clinical-neural profiles, supporting more neurobiologically informed stratification for ADHD management.

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Podcast cover featuring 'Author Interviews'. Article: 'Once-Weekly Semaglutide in Adults With Alcohol Use Disorder. JAMA Psychiatry Author Interviews'. A play button is visible.

John Torous, MD, spoke with Christian S. Hendershot, PhD, and Klara R. Klein, MD, PhD, about the crossover between metabolic health and alcohol use disorder and why #GLP-1s are sparking a new wave of optimism in behavioral health.

Listen now: ja.ma/4063ZQ6

Two plots labeled A and B show polygenic scores and sleep phenotypes in adolescence. Plot A: Sleep duration, sleep onset latency and midpoint. Plot B: wake after sleep onset, sleep onset latency > text@20 min, insomnia symptoms, daytime sleepiness and naps.

Adult sleep GWAS-derived polygenic scores demonstrated comparable associations with corresponding sleep phenotypes in #Adolescents, suggesting genetic influences on sleep persist across developmental stages.

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JAMA Psychiatry: Brain and Blood Biomarkers of Major Depressive Disorder. Review by Lia J. Zallar, PhD; Maura B. Dupont, MD, PhD. Text discusses MDD, GWASs, biomarkers, treatment targets, and omic studies. Published online February 25, 2026.

In #MajorDepressiveDisorder, shared brain and blood biomarkers indicate disrupted mitochondrial metabolism, neurodevelopment, inflammation, transcription, and apoptotic pathways, highlighting potential biomarker and treatment targets.

Learn more in this Review: ja.ma/476bxpI

Fig 5: Spatial Correlations of Neurotransmitters With Biotype-Specific Deviations. Three radar charts labelled Biotype 1, Biotype 2, Biotype 3 each plot neurotransmitter spatial correlations around a central point from -0.4 to 0.4.

Normative modeling of morphometric similarity networks in #ADHD identified three distinct biotypes with unique clinical-neural profiles, supporting more neurobiologically informed stratification for ADHD management.

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Two bar graphs compare changes in CES-D scores. Graph A, "Causal forest model," shows SBMT having d=0.07, P=.007, and TAU having d=-0.01, P=.82. Graph B, "Elastic net regression model," shows SBMT having d=0.08, P=.004, and TAU having d=0, P>.99.

Machine learning analyses in the MYRIAD trial found only clinically trivial personalization of school-based mindfulness for adolescent #Depression prevention, underscoring limited differential benefit in universal programs.

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Figure 3, Meta-Regressions of Significant Study Variables, shows five scatter plots, each examining different variables. A shows IQ difference between groups, B age difference, C percentage of females, D inpatient status, E presence of schizoaffective disorder.

Meta-analysis indicates that individuals with #Schizophrenia show pronounced deficits in symbol coding tasks, with processing speed impairment exceeding most other cognitive domains.

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JAMA Psychiatry article: "Spirituality and Harmful or Hazardous Alcohol and Other Drug Use: A Meta-Analysis of Longitudinal Studies" by Howard K. Koh, Donald E. Frederick, and Tracy A. Balboni. Published Feb 18, 2026.

Spiritual exposures, including regular religious community attendance, are consistently associated with lower risk of harmful or hazardous alcohol and other drug use in longitudinal studies.

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Podcast cover for JAMA Psychiatry Author Interviews, dated February 18, 19 minutes. Title: Predicting Adolescent Response to School-Based Mindfulness. A blue square displays 'Psyc' and initials 'JN'. A purple play button is at the bottom.

John Torous, MD, speaks with Christian A. Webb, PhD, of Harvard Medical School and McLean Hospital, about the limits of population-level prediction and the need for more potent and targeted interventions for #YouthMentalHealth.

🎧 Listen now:
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Line graph of PTSD scale changes over time. The X-axis represents 'Study day' from 1 to 64. The Y-axis shows 'LS mean (SE) change from baseline' from 0 to -30. Placebo and TSND-201 are plotted, with TSND-201 showing a greater decrease.

Among adults with #PTSD, intermittent oral TSND-201 treatment produced greater reductions in PTSD symptoms than placebo and was well tolerated, supporting its potential as a rapid-acting, durable pharmacologic option.

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An article titled 'Depressive Symptoms and Associated Factors Among Kenyan Health Care Workers' by Andrew Aballa, MSc1; Dorcas G. Mwigereri, MSc2; Zhuo Zhao, MS3; Published Online: December 10, 2025 in JAMA Psychiatry.

Among Kenyan health care workers surveyed, 43.1% met criteria for major depression during at least one assessment over 12 months. ja.ma/4qkJdXI

JAMA Psychiatry journal cover. Title: Spirituality and Harmful or Hazardous Alcohol and Other Drug Use. Authors: Howard K. Koh, MD, MPH@1; Donald E. Frederick, PhD@2; Tracy A. Balboni, MD, MPH@3; et al. Published Online: February 18, 2026.

Spiritual exposures, including regular religious community attendance, are consistently associated with lower risk of harmful or hazardous alcohol and other drug use in longitudinal studies.

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Two bar graphs compare 'Change in CES-D score (post - pre)' for SBMT and TAU interventions. Graph A uses a 'Causal forest model,' while Graph B uses an 'Elastic net regression model.' Each graph displays d and P values for both interventions.

Machine learning analyses in the MYRIAD trial found only clinically trivial personalization of school-based mindfulness for adolescent #depression prevention, underscoring limited differential benefit in universal programs.

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JAMA Psychiatry viewpoint: "Recognizing Grief in Neurodivergent Minds" by Kerim M. Munir, MD, MPH, DSc1,2. Published online December 23, 2025. doi: 10.1001/jamapsychiatry.2025.4225.

💬 Viewpoint: Prolonged grief disorder may manifest differently in neurodivergent individuals, requiring clinicians to assess behavioral changes and loss of support rather than relying solely on typical diagnostic criteria.

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Line graph shows PTSD scale changes over 64 days for Placebo and TSND-201. The x-axis represents study day, and the y-axis shows LS mean change from baseline. TSND-201 shows a greater decrease in PTSD symptoms compared to Placebo.

Among adults with #PTSD, intermittent oral TSND-201 treatment produced greater reductions in PTSD symptoms than placebo and was well tolerated, supporting its potential as a rapid-acting, durable pharmacologic option.

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