Timothy En Haw Chan

A disease model resource reveals core principles of tissue-specific cancer evolution - Nature The Mouse Cancer Cell line Atlas (MCCA) provides major advances towards a mechanistic understanding of cancer genomes.

A disease model resource reveals core principles of tissue-specific cancer evolution.

www.nature.com/articles/s41...

Organism-wide cellular dynamics and epigenomic remodeling in mammalian aging To investigate organism-wide cellular alterations and epigenomic dynamics during aging, we constructed a single-cell chromatin accessibility atlas spanning 21 mouse tissues across three age groups and...

Organism-wide cellular dynamics and epigenomic remodeling in mammalian aging
www.science.org/doi/10.1126/...

The epigenetic circle: feedback loops in the maintenance of cellular memory - Epigenetics & Chromatin The memory of gene expression states, active or repressive, is a fundamental biological concept as it controls cell fate in development, immunity and abiotic stress responses. Such memory is maintaine...

A nice piece to read:
The epigenetic circle: feedback loops in the maintenance of cellular memory.

link.springer.com/article/10.1...

How fasting boosts breast cancer therapy A discovery in mice reveals why fasting enhances a type of breast cancer treatment — a hormone-signalling pathway and gene-expression changes have key roles.

A discovery in mice reveals why fasting enhances a type of breast cancer treatment

go.nature.com/4oUCGCk

Molecular determinants for recognition of serotonylated chromatin Abstract. Post-translational modifications of histone tails constitute a key epigenetic mechanism controlling chromatin environment and gene transcription.

Molecular determinants for recognition of serotonylated chromatin
academic.oup.com/nar/article/...

Contrasting roles of KMT2C and KMT2D in breast cancer - Scientific Reports Scientific Reports - Contrasting roles of KMT2C and KMT2D in breast cancer

Contrasting roles of MLL3 and MLL4 histone methyltransferases in breast cancer

www.nature.com/articles/s41...

Requirements for establishment and epigenetic stability of mammalian heterochromatin Tatarakis et al. study how H3K9me3 heterochromatin is formed and inherited in mammalian cells. Using a synthetic heterochromatin assembly system and genetic screens, they uncover requirements for init...

Requirements for establishment and epigenetic stability of mammalian heterochromatin.
www.cell.com/molecular-ce...

Extrachromosomal DNA associates with nuclear condensates and reorganizes chromatin structures to enhance oncogenic transcription Taghbalout et al. apply collections of advanced multi-omics analyses to substantiate ecDNA’s mobile enhancer model in diverse types of cancer models, reveal the MED1-ecDNA condensates and establish their causal links to the modulation of oncogenic expression and cell proliferation. This study offers a chromatin-based mechanism of ecDNA function in cancer.

Online Now: Extrachromosomal DNA associates with nuclear condensates and reorganizes chromatin structures to enhance oncogenic transcription

Multiomic profiling reveals that prostaglandin E2 reverses aged muscle stem cell dysfunction, leading to increased regeneration and strength Wang et al. uncover that aged muscle stem cells have blunted PGE2-EP4 signaling that is critical for their regenerative function. Treatment with exogenous PGE2 reverses age-related defects in muscle stem cells and imparts an epigenetic response that enhances their capacity for repair after injury and transplantation.

Multiomic profiling reveals that prostaglandin E2 reverses aged muscle stem cell dysfunction, leading to increased regeneration and strength

Pan-viral ORFs discovery using massively parallel ribosome profiling Defining viral proteomes is crucial to understanding viral life cycles and immune recognition but the landscape of translated regions remains unknown for most viruses. We have developed massively para...

With the help of a technique called Massively Parallel Ribosome Profiling, researchers in Science have identified more than 4000 open reading frames—stretches of genetic material that can encode proteins—across 679 human-associated viral genomes. scim.ag/43RoAdF

Trichophyton concentricum fungal infections and skin microbiomes of Indigenous Peninsular Malaysians Indigenous Orang Asli of Peninsular Malaysia raised concerns about the etiology, treatment, and transmission routes of the skin disorder tinea imbricata. Analyses of the associated Trichophyton concen...

Research about host-microbiome co-evolution on fungal infection in indigenous Malaysians, done by University of Malaya and NIH, on Cell.

www.cell.com/cell/fulltex...

Serotonin transporter inhibits antitumor immunity through regulating the intratumoral serotonin axis Serotonin transporter (SERT) inhibits CD8 T cell antitumor immunity by depleting intratumoral serotonin. SERT-blocking selective serotonin reuptake inhibitor (SSRI) antidepressants enhance CD8 T cell antitumor immunity and synergize with anti-PD-1, highlighting SSRIs as potential cancer immunotherapeutics.

Now online! Serotonin transporter inhibits antitumor immunity through regulating the intratumoral serotonin axis

👀Preview for Lane et al: Cellular reprogramming by protein degradation: The next frontier in cancer immunotherapy by Anjana Rao @AnjanaRaoLab, Erik Ehinger @erik_ehinger at

The new issue is out! 👉 cell.com/cell/current
⁠
In this issue of Cell, Yu et al. capture evolution of KoRV-A transcriptional silencing as the virus transitions from a pathogen to a stable endogenous retrovirus. The cover features an adult koala with a joey.

📷 Credit: Currumbin Wildlife Sanctuary

Integrator loss leads to dsRNA formation that triggers the integrated stress response Integrator (INT) prevents the escape of immature RNAPII to ensure full-length mRNA production. INT deficiency causes defects in RNAPII maturation that lead to premature termination, accumulation of immunogenic dsRNA, and activation of the integrated stress response (ISR) observed in patient cells.

Now online! Integrator loss leads to dsRNA formation that triggers the integrated stress response

Symposium: Epigenetics of early mouse development We are delighted to invite you to to the second symposium, “Epigenetics of Early Mouse Development”, taking place on April 24, 2025, at the Max Planck Institute of Immunobiology and Epigenetics in Fre...

Interested in the latest advancements of #epigenetics of #mammalian early embryogenesis? Then join our upcoming mini-symposium in Freiburg!

📅 April 24, 2025, 14:00-19:00 PM
📌 Max Planck Institute, Freiburg (only on-site!)
🛠️ Organized by: @iovino-lab.bsky.social

Register & join free of charge.

Welcome to share it with bioscience undergraduate/graduate students who may interest to have a short term internship in Taiwan.

Project detail:

TAIWAN EXPERIENCE EDUCATION PROGRAM

teep.studyintaiwan.org/program/1178
For non-official advise, feel free to inbox me as I am one of the MMRC/CGU alumni who I did my bachelor and master research there.

The internship prefer for Asian countries (but not limited to) to participate in 6 short-term professional internship projects lasting 2 months.

Period of Apply: 2025/03/01 – 2025/5/31
Internship Duration: 2025/06/01 – 2025/09/30
For more detail, please check the webpage.

TAIWAN EXPERIENCE EDUCATION PROGRAM

🧑‍🔬 Summer Research Internship opportunity focus on multi-omics technologies and AI in Precision Medicine.
🧬💻🤖💊
Molecular Medicine Research Center (MMRC) at Chang Gung University, Taiwan will offer 8 internship positions for international students.

teep.studyintaiwan.org/program/1178

Aspirin prevents metastasis by limiting platelet TXA2 suppression of T cell immunity - Nature Inhibition of cyclooxygenase 1 releases T cells from immunosuppression by platelet-derived thromboxane A2, thereby enhancing the immune response against metastasis.

Aspirin slow cancer metastasis by decrease platelet TXA2 and releasing T cells from suppression.

www.nature.com/articles/s41...

The guide I wish I had 12 years ago

The guide I wish I had 12 years ago: a step-by-step guide to replicate a genomics paper figure divingintogeneticsandgenomics.kit.com/32726a816b

Tumour-wide RNA splicing aberrations generate actionable public neoantigens - Nature A study identifies public neoantigens generated by tumor-wide aberrant mRNA splicing activity across distinct cancer types.

Nature research paper: Tumour-wide RNA splicing aberrations generate actionable public neoantigens

https://go.nature.com/4hTQ0UW

Rare genetic disorder treated in womb for the first time The child, who is now almost three years old, shows no signs of the often fatal motor neuron disease.

A two-and-a-half-year-old girl shows no signs of a rare genetic disorder, after becoming the first person to be treated for the motor-neuron condition while in the womb.

https://go.nature.com/41a7Zzj

Transcriptional Dosage of Oncogenic KRAS Drives Lung Adenocarcinoma Cell States, Progression and Metastasis Cancer cells display distinct, recurrent phenotypic cell states. Metastatic spreading correlates with tumor cell state evolution. However, the molecular mechanisms underlying metastasis remain elusive...

In www.biorxiv.org/content/10.1... we propose that #KRAS #dosage integrates signaling & transcription to regulate cell states, driving #heterogeneity, progression & #metastasis

If you want to learn single-cell analysis from scratch with an user friendly, hands on, approach I very strongly recommend the series of FREE workshops offered by the SAIL team at @mskcancercenter.bsky.social , lead by @ronanchaligne.bsky.social .
sail.mskcc.org/computationa...

Advertisement for fully funded Max Planck PhD positions highlighting a research program for International Max Planck Research School of Epigenetics, Biophysics and Metabolim. The image shows a green fluorescent microscopy view of Drosophila tissue alongside text promoting PhD opportunities in Freiburg, Germany, with an application deadline of February 28, 2025.

Our 🔥 brand-new PhD program IMPRS-EBM at the intersection of #Epigenetics, #Biophysics & #Metabolism is open for applications📢. Looking for a fully-funded #PhDposition at Max Planck? Here is your chance: www.ie-freiburg.mpg.de/IMPRS-PhD-Pr...

Welcome! You are invited to join a webinar: Info Session: New Strategies for Proximity Induction between Novel Target Combinations in Solid Tumors. After registering, you will receive a confirmation e... Join this info session to learn more about the open Call for Application from Daiichi Sankyo and BioMed X! Available position is Group Leader on "New Strategies for Proximity Induction between Novel T...

Want to apply to our next Call for Application in collaboration with Daiichi Sankyo? Join our Infosession on 14th February 2025, at 6:00 PM CET (12:00 PM EST | 9:00 AM PST) to learn everything you need to know
us02web.zoom.us/webinar/regi...

H3K4 methylation-promoted transcriptional memory ensures faithful zygotic genome activation and embryonic development In the life of a vertebrate embryo, gene expression is initiated for the first time at zygotic genome activation (ZGA). Maternally expressed transcription factors present in the embryo are essential f...

✨ Excited to share my latest preprint on how H3K4 methylation promotes transcriptional memory from gametes to embryos across a transcriptionally silent window — crucial for proper zygotic genome activation and development. 🐸🧬✨

📄 Check it out here:
doi.org/10.1101/2025...

👇 Highlights below

X chromosome passed from mother to daughter influences brain ageing X-chromosome inactivation affects age-related decline in spatial memory.

The role of the maternal X chromosome in brain aging
www.nature.com/articles/s41...
www.nature.com/articles/d41...
@nature.com