Genes & Diseases Journal

This review shows #glycometabolic reprogramming fuels #Osteosarcoma progression via #glycolysis, mitochondrial dysfunction & immune suppression, highlighting metabolic targeting as a promising strategy to overcome therapy resistance.

#OpenAccess: doi.org/10.1016/j.ge...

This study shows that single-cell profiling of #HCC under anti-PD-1 therapy reveals #Tcell exhaustion trajectories linked to tumor–immune crosstalk, highlighting exhaustion as a key target to improve #immunotherapy outcomes. #SingleCellRNASequencing

#OpenAccess: doi.org/10.1016/j.ge...

Researchers identify NFIA as a key regulator of #BoneHomeostasis, and its loss in mesenchymal progenitors disrupts bone balance by enhancing resorption over formation, linking NFIA deficiency to age-related #osteoporosis. #osteoclastogenesis

#OpenAccess: doi.org/10.1016/j.ge...

#Aging increases susceptibility to #tenofovir-induced mitochondrial toxicity in #RenalStemCells, with a #3D silk matrix model revealing age-specific injury and providing a platform for safer, targeted kidney therapies. @wakeforest.bsky.social

#OpenAccess: doi.org/10.1016/j.ge...

Single-cell analyses reveal #VascularEndothelialCells act as non-professional #phagocytes in #Atherosclerosis, where #SRB1 drives apoptotic debris uptake via #adherensjunction and cytoskeleton remodeling, uncovering a novel clearance pathway.

#OpenAccess: doi.org/10.1016/j.ge...

📣 All accepted Proffered Paper, Mini Oral, Poster and ePoster abstracts for #ESMORareCancers26 are now online!
Dive into the latest research advancing sarcoma and rare cancers care.

🔗 https://ow.ly/GQI450Yp3SR

#esmomeetings

#Narciclasine induces #MitochondrialApoptosis in #ColonCarcinoma cells by inhibiting the IL-17A/Act1/TRAF6/NF-κB signaling, establishing it as a potent therapeutic agent against #ColorectalCancer.

#OpenAccess: doi.org/10.1016/j.ge...

#Multiomics reveals reduced #FGF21 as a driver of #LiverAging, linking suppressed peroxisome and fatty acid pathways with cell cycle decline; FGF21 restoration boosts #antioxidant defense and regeneration, highlighting a therapeutic target.
#OpenAccess: doi.org/10.1016/j.ge...

This study identified PDCD2 as a prognostic #Biomarker in #Glioma, showing that its overexpression promotes tumor progression and correlates with malignancy & poor survival, marking it as a potential #TherapeuticTarget.

#OpenAccess: doi.org/10.1016/j.ge...

#Multiomics analysis reveals stage-specific targets in #TALL, highlighting CDK6, TUBA1A, TUBB and TYMS dysregulation across maturation stages; repurposed #mebendazole and #gemcitabine show selective #antileukemic activity.

#OpenAccess: doi.org/10.1016/j.ge...

📣 #ESMO26: The registration system is now open!
Join us at an event where multidisciplinary innovation meets global collaboration.
⏰ Big savings if you register before 22 July 2026

🔗 https://ow.ly/lg7S50YoACx

#esmomeetings

🚀 The 1st EORTC Summit in Clinical Cancer Research is coming!

AI, innovative methodologies, QOL, patient‑centricity, policy & more — all in one place.

📅 Save the date & help spread the word!
👉 www.eortc.org/summit

#EORTCSummit

This study reveals that the SOX9–MMP10–ECM axis drives tracheal fibrosis post-injury via the Wnt/β-catenin signaling pathway, highlighting the targeted inhibition of SOX9 as a potent therapeutic strategy in #TrachealStenosis.

#OpenAccess: doi.org/10.1016/j.ge...

#ERStress activates IRE1α–XBP1s to upregulate hIAPP transcription via an ACGT site, driving β-cell dysfunction in #type2diabetesmellitus (#T2DM); blocking #XBP1 splicing with MKC3946 lowers IAPP and improves β-cell survival.
#OpenAccess: doi.org/10.1016/j.ge...

This study reveals that Cdc42 deficiency causes enamel defects by disrupting mitochondrial function and inducing oxidative stress in the dental epithelium, highlighting its critical role in ameloblast differentiation.

#OpenAccess: doi.org/10.1016/j.ge...

This review describes the role of DEAD-box RNA helicases as critical hematopoiesis regulators, detailing how their post-transcriptional dysfunction promotes #HematologicalMalignancies and offers avenues for #CancerTherapy.

#OpenAccess: doi.org/10.1016/j.ge...

This review examines how bidirectional brain-body signaling and integrated immune-endocrine pathways drive #MajorDepressiveDisorder, providing perspectives for precision-oriented therapeutic strategies. @wakeforest.bsky.social

#OpenAccess: doi.org/10.1016/j.ge...

Join leading experts at the Ischemic Heart Disease Track at #ICNC2026 and explore the latest in #nuclearcardiology. From PET for sichemia, to CAD debates, post-revascularization chest pain, and INOCA, sharpen your skills for daily practice.

🔗 https://bit.ly/4l2SaDP

Primary care professionals play a critical role in the early diagnosis of NENs.
#ThinkNENs Program is here to help – and it's completely FREE.
✔ 60-minute CME-accredited module
✔ 7 languages
✔ Endorsed by leading NEN societies
Explore here: incalliance.org/think-nens/
#LetsTalkAboutNETs

📢 You can still join us today!
The ESTRO Gyn-SMART community invites you to a peer-to-peer discussion on late effects and supportive care in gynecological radiotherapy.

📅 Today | ⏰ 16:00–17:00 CET
💻 Online

ℹ️More info: https://bit.ly/4s0SXaz
👉 https://bit.ly/4slOTlN

#GynSMART #RadiationOncology

Elevated S100A9 in #HFpEF hearts drives oxidative stress and mitochondrial dysfunction; its deficiency restores #SIRT3 signaling, improves diastolic function, and reduces #hypertrophy and #fibrosis, supporting S100A9 as a therapeutic target.

#OpenAccess: doi.org/10.1016/j.ge...

Using integrated #scRNAseq, #Immunofluorescence, and functional validation, this study shows that the #Immunosuppressive #TumorMicroenvironment contributes to tumor aggressiveness in lymphovascular invasion-positive #PDAC.

#OpenAccess: doi.org/10.1016/j.ge...

A #disulfidptosis-based model for #HeadAndNeckCancer predicts survival and links low-risk #tumors to stronger immunity, while #multiomics highlight CXCL12–CXCR4 and identify #NQO1, with #dicoumarol boosting checkpoint therapy.

#OpenAccess: doi.org/10.1016/j.ge...

This review provides insights into #Epigenetic alterations in #Cancer and the #TumorMicroenvironment, outlining their roles in tumor progression and the therapeutic potential of epigenetic drugs and combination strategies.

#OpenAccess: doi.org/10.1016/j.ge...

This review highlights how NAD⁺/NADH and NADP⁺/NADPH homeostasis—regulated by NAD kinases, MESH1, NOCT, and circadian control—governs cellular metabolism and redox balance, with dysregulation linked to #cancer and #MetabolicDisease. #Nocturnin

#OpenAccess: doi.org/10.1016/j.ge...

This review elucidates the regulatory role of #m6A modification in #PCD pathways, highlighting its influence on #CardiovascularDisease progression and its emerging potential as novel diagnostic and #TherapeuticTarget.

#OpenAccess: doi.org/10.1016/j.ge...

Anyone can register for Thursday's FREE webinar on 'Unmasking Cancer Complexity: Gaining Multi-Dimensional Clarity through Multiomic Innovation'. 15:00 CET. Register: us02web.zoom.us/webinar/regi...

The IASLC Hot Topic Meeting returns this June, bringing together scientists, clinicians, and thought leaders to explore resistance to #immunotherapy in #lungcancer.
🗓️ Registration & abstracts open in March

Learn More: bit.ly/4rGmTc3

#HT26

Applications are open for the @conquercancer.bsky.social Young Investigator Award in Early Cancer Detection. provides funding for physicians during the transition from a fellowship or training program to a faculty appointment.

Apply by March 30, 2026: https://bit.ly/4aJG1Al
#CancerResearch

This review outlines #CorticalDevelopment and genetic causes of malformations of cortical development, highlighting PI3K/PTEN/AKT/mTOR signaling, advances in diagnosis and models, and emerging targeted therapeutic strategies. #IntellectualDisability

Read: doi.org/10.1016/j.ge...