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Simon Anders

@s-anders

physicist, bioinformatics / biostats researcher at University of Heidelberg

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23.09.2024
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Latest posts by Simon Anders @s-anders

When a US missile killed 160 children, president shits-a-lot claimed Iran stole the missile and fired at the school. When asked why he was the only one making this claim, he said "because I just don't know enough about it".
Go ahead. See if you can make this make sense.
(Source: RB Hubbell)

10.03.2026 11:01 πŸ‘ 6855 πŸ” 1482 πŸ’¬ 420 πŸ“Œ 85
MYTH: As commander-in-chief, Trump has the authority to take military action.

FACT: It is unconstitutional for a U.S. president to declare war without the approval of the Knesset.

MYTH: As commander-in-chief, Trump has the authority to take military action. FACT: It is unconstitutional for a U.S. president to declare war without the approval of the Knesset.

Trump’s War On Iran: Myth Vs. Fact https://theonion.com/trumps-war-on-iran-myth-vs-fact/

07.03.2026 22:00 πŸ‘ 1780 πŸ” 271 πŸ’¬ 21 πŸ“Œ 15

In Deutschland denken Frauen heute darΓΌber nach, ihre Babys abzutreiben, weil die Wohnung zu klein ist. Keine bezahlbare Wohnung, keine Kinder. Und die CDU will die Partei von Familie und Heimat sein? In den 60er Jahren schuf die CDU "das Wohnungswunder"! FΓΌr Adenauer war…

07.03.2026 08:32 πŸ‘ 384 πŸ” 91 πŸ’¬ 17 πŸ“Œ 1
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Wissenschaftliche*r GeschΓ€ftsfΓΌhrer*in (w/m/d) - Zentrum fΓΌr Molekulare Biologie der UniversitΓ€t Heidelberg - UniversitΓ€t Heidelberg UniversitΓ€t Heidelberg bietet Stelle als Wissenschaftliche*r GeschΓ€ftsfΓΌhrer*in (w/m/d) - Zentrum fΓΌr Molekulare Biologie der UniversitΓ€t Heidelberg in Heidelberg - jetzt bewerben!

We are are searching a scientific manager for the ZMBH. This position requires a life sciences PhD & excellent German skills, therefore the advertisement is formulated in German. Very good English skills are needed as well. You are welcome to share the ad:
www.academics.de/jobs/wissens...

05.03.2026 14:07 πŸ‘ 1 πŸ” 1 πŸ’¬ 0 πŸ“Œ 0
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Benchmarking EGF signaling pathway inference using phosphoproteomics and kinase-substrate interactions - Nature Communications To what extent can large-scale approaches accurately reconstruct classic signaling pathways? Here, authors revisit the EGF pathway using phosphoproteomics and kinase-substrate interactions

Is the linear map of cell signaling a myth?
New research suggests the reality of cellular networks is more complex.
@savitski-lab.bsky.social & @saezlab.bsky.social combined experimental and computational expertise to test how we map kinase–substrate interactions.
www.nature.com/articles/s41...

05.03.2026 09:57 πŸ‘ 10 πŸ” 4 πŸ’¬ 0 πŸ“Œ 0
Screenshot of an X post by Republicans Against Trump reporting claims that commanders at multiple U.S. bases told troops the Iran war is part of β€œGod’s plan” and linked to Armageddon. Below is a photo of Trump standing with several evangelical leaders praying around him.

Screenshot of an X post by Republicans Against Trump reporting claims that commanders at multiple U.S. bases told troops the Iran war is part of β€œGod’s plan” and linked to Armageddon. Below is a photo of Trump standing with several evangelical leaders praying around him.

The religious right has infiltrated far into our military with disturbing consequences.

05.03.2026 00:30 πŸ‘ 2082 πŸ” 549 πŸ’¬ 221 πŸ“Œ 65

The main project of my PhD πŸ§¬πŸ”¬ is out: we developed single-cell lentiMPRA, a lentivirus-based method to measure enhancer activity and transcriptomes at single-cell resolution. We then applied sc-lentiMPRA to fully synthetic enhancers 🧩...

πŸ”— doi.org/10.64898/202...

04.03.2026 10:25 πŸ‘ 37 πŸ” 10 πŸ’¬ 3 πŸ“Œ 3

Now, synthetic enhancers with single cells - great work by @juruehle.bsky.social : www.biorxiv.org/content/10.6...

04.03.2026 11:33 πŸ‘ 9 πŸ” 2 πŸ’¬ 0 πŸ“Œ 0
Screenshot of the "Does that use a lot of energy?" online app

Screenshot of the "Does that use a lot of energy?" online app

Hannah Ritchie has built a fun little tool where you can compare energy usage of various products and activities.

This is super helpful imho, because it's so hard to develop intuitions even just about the scales involved here.

hannahritchie.substack.com/p/does-that-...

03.03.2026 09:27 πŸ‘ 153 πŸ” 66 πŸ’¬ 3 πŸ“Œ 5
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Chance and Consensus in Peer Review (1981) www.science.org/doi/10.1126/... tltle: it's a lottery system)

26.02.2026 15:00 πŸ‘ 5 πŸ” 1 πŸ’¬ 0 πŸ“Œ 0
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The molecular evolution of vertebrate organs Nature Ecology & Evolution - This Review discusses recent advances in the molecular evolution of vertebrate organs, including rates of evolution of organs and cell types, molecular mechanisms...

Our internal organs are evolutionary marvels. New technologies are transforming our understanding of the evolution of vertebrate organs. You can find more by reading here:
rdcu.be/e5EgU
#EvoBio #EvoDevo πŸŸπŸ¦ŽπŸ’πŸ¦‡πŸŠπŸ¦œ

25.02.2026 12:29 πŸ‘ 140 πŸ” 52 πŸ’¬ 2 πŸ“Œ 5
Democrats Wear White Flag Pins To SOTU To Indicate Surrender

Democrats Wear White Flag Pins To SOTU To Indicate Surrender

Democrats Wear White Flag Pins To SOTU To Indicate Surrender

25.02.2026 02:26 πŸ‘ 6068 πŸ” 852 πŸ’¬ 75 πŸ“Œ 37
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THERE’S POWER IN BOYCOTTING!

24.02.2026 21:50 πŸ‘ 5781 πŸ” 1737 πŸ’¬ 209 πŸ“Œ 117
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See how thunderstorms create ghostly UV sparks on the tips of trees Thunderstorms can generate weak electrical discharges on the plants underneath, but until now, they had never been observed in nature

Thunderstorms can generate weak electrical discharges on the plants underneath, but until now, they had never been observed in nature

24.02.2026 18:42 πŸ‘ 997 πŸ” 249 πŸ’¬ 18 πŸ“Œ 26
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Press the Red Button, Dave A small study at LANL has real-world biosecurity relevance: evaluating whether AI can transfer tacit laboratory skill to novices.

Press the Red Button, Dave. A small study at LANL has real-world #biosecurity relevance: evaluating whether AI can transfer tacit laboratory skill to novices. doi.org/10.59350/6e0...

23.02.2026 10:46 πŸ‘ 1 πŸ” 1 πŸ’¬ 0 πŸ“Œ 0
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Illness Is rampant among children trapped in ICE’s massive jail in Texas The number of people held at the notorious Dilley immigration jail has nearly tripled since October.

THIS πŸ‘‡is pure EVIL.

18.02.2026 14:51 πŸ‘ 2216 πŸ” 1210 πŸ’¬ 11 πŸ“Œ 81
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Cross-species comparison reveals therapeutic vulnerabilities halting glioblastoma progression - Nature Communications Understanding the growth dynamics of GBMs can help expand therapeutic options. Here, authors use a cross-species computational approach to compare GBM cells to healthy neural stem cells, identifying p...

πŸ“– Our new pseudotime alignment tool ptalign identifies Wnt antagonist SFRP1 as central for glioblastoma cell activation, opening new avenues for patient stratification and therapeutic avenues.

πŸ”— lnkd.in/ees8bhNY
by @Leo Carl Foerster, Oguzhan Kaya et al.

#glioblastoma #pseudotime #neurobiology

19.02.2026 10:18 πŸ‘ 3 πŸ” 1 πŸ’¬ 0 πŸ“Œ 0
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ggannotate: interactively add annotations to your {ggplot2} plots by pointing and clicking github.com/MattCowgill/... #Rstats

19.02.2026 10:49 πŸ‘ 33 πŸ” 9 πŸ’¬ 2 πŸ“Œ 0

Absolutely savage, I love it.

09.02.2026 11:51 πŸ‘ 65 πŸ” 8 πŸ’¬ 0 πŸ“Œ 0
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With all the excitement about AI giving us answers, we often forget that the real trick is to figure out what is the question.

29.12.2025 17:02 πŸ‘ 42 πŸ” 13 πŸ’¬ 0 πŸ“Œ 1
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8/ 🀘 For those about to rock (around the Christmas tree), we salute you πŸŽΈπŸŽ„: Isabelle Seufert & our team from @dkfz.bsky.social & BioQuant & @akispapantonis.bsky.social, Philipp Mallm, @s-anders.bsky.social & Petros Kolovos labs with support from @spp2202.bsky.social & @mspacealliance.bsky.social.

24.12.2025 22:54 πŸ‘ 3 πŸ” 2 πŸ’¬ 1 πŸ“Œ 0
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1/ πŸŽ„ We got our Christmas present today: "Two distinct chromatin modules regulate proinflammatory gene expression" is now published @natcellbio.nature.com doi.org/10.1038/s415.... Our study introduces a scATAC-seq-based framework for genome-wide analysis of gene regulation features.

24.12.2025 22:44 πŸ‘ 77 πŸ” 25 πŸ’¬ 3 πŸ“Œ 2
Screenshot from project 2025 that says By statute or regulation, CDC guidance must be prohibited from taking on a prescriptive character. For example, never again should CDC officials be allowed to say in their official capacity that school children "should be" masked or vaccinated (through a schedule or otherwise) or prohibited from learning in a school building.
Such decisions should be left to parents and medical providers. We have learned that when CDC says what people "should" do, it readily becomes a "must" backed by severe punishments, including criminal penalties. CDC should report on the risks and effectiveness of all infectious disease-mitigation measures dispassionately and leave the "should" and "must" policy calls to politically accountable parties.
Conflicts of Interest. There was a time when the CDC could not take money

Screenshot from project 2025 that says By statute or regulation, CDC guidance must be prohibited from taking on a prescriptive character. For example, never again should CDC officials be allowed to say in their official capacity that school children "should be" masked or vaccinated (through a schedule or otherwise) or prohibited from learning in a school building. Such decisions should be left to parents and medical providers. We have learned that when CDC says what people "should" do, it readily becomes a "must" backed by severe punishments, including criminal penalties. CDC should report on the risks and effectiveness of all infectious disease-mitigation measures dispassionately and leave the "should" and "must" policy calls to politically accountable parties. Conflicts of Interest. There was a time when the CDC could not take money

It is utterly catastrophic that RFK Jr. plans to end CDC recommendations for most childhood vaccines.

It’s a betrayal of science, ethics, compassion, and the people of the United States.

And it was also a specific goal of Project 2025 (page 254).

20.12.2025 00:50 πŸ‘ 7333 πŸ” 2815 πŸ’¬ 228 πŸ“Œ 213
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This is the most alarming story I’ve read today. Giving up the fight before it’s started

30.11.2025 09:57 πŸ‘ 3274 πŸ” 1225 πŸ’¬ 329 πŸ“Œ 328
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ISCO (Innovations in Single-Cell OMICS) will be back in beautiful Barcelona!

πŸ—“οΈ 28th/29th of May 2026
πŸ“Barcelona Biomedical Research Park @prbb.org (beachfront!)

Keynotes: @bartdeplancke.bsky.social and @bocklab.bsky.social

Submit your abstract and present your research!

www.isco-conference.eu

05.12.2025 10:32 πŸ‘ 21 πŸ” 13 πŸ’¬ 2 πŸ“Œ 6
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The CNRS is breaking free from the Web of Science From January 1st 2026, the CNRS will cut access to one of the largest commercial bibliometric databases, Clarivate Analytics'

One step in the right direction from @cnrs.fr . Here’s hoping others will follow and we can get some more space for actual science. πŸ§ͺ www.cnrs.fr/en/update/cn...

03.12.2025 20:07 πŸ‘ 15 πŸ” 10 πŸ’¬ 1 πŸ“Œ 2
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A genome-scale single-cell CRISPRi map of trans gene regulation across human pluripotent stem cell lines Feng et al. present the first genome-scale CRISPR interference perturbation map with scRNA-seq readout across many genetic backgrounds in human pluripotent cells, pioneering population-scale CRISPR pe...

Happy to see this out now in Cell Genomics: A genome-scale single-cell CRISPRi map of trans gene regulation across human pluripotent stem cell lines: www.cell.com/cell-genomic...

03.12.2025 09:17 πŸ‘ 27 πŸ” 10 πŸ’¬ 3 πŸ“Œ 1
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Ensembl 2026 Abstract. The Ensembl project (https://www.ensembl.org) is a public and open resource providing access to genomes, annotations, high-quality tools, and met

Our Ensembl 2026 paper is out!
Learn about 1,900+ new genomes, expanded pangenome support, new regulation interfaces, and what’s coming in our 2026 releases.
doi.org/10.1093/nar/gkaf1239

28.11.2025 16:30 πŸ‘ 13 πŸ” 9 πŸ’¬ 0 πŸ“Œ 1
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Postdoctoral fellow - Petsalaki Group - NetworkCommons Your group The Petsalaki, Saez-Rodriguez (EMBL-EBI) and KorcsmΓ‘ros (Imperial College) groups develop cutting-edge computational and AI approaches to unravel cellular signalling and gene regulation fro...

#Postdoc alert! We are looking for motivated individual with experience in computational systems biology to join our NetworkCommons initiative to benchmark and democratise network contextualisation methods across multiple applications. Deadline Dec 17th link here: tinyurl.com/yrrzxa94

26.11.2025 17:05 πŸ‘ 5 πŸ” 9 πŸ’¬ 1 πŸ“Œ 0
Comic. Panels up to the 10-year point are grayed out. New panels since the Ten Years comic, which chronicles the first ten years of PERSON 1's journey with cancer: (1) [two people in bed] PERSON 1 (woman): One more chapter? PERSON 2 (man): Don’t we both have to get up early? PERSON 1: Nnnnnggggh PERSON 2: Sure, good point. (2) [many people wearing masks, walking while looking at graphs on their phones] (3) [birds landing on people] PERSON 2 in beanie and scarf: Hah! They like *my* seeds best. PERSON 1 in scarf holding phone with a bird sitting on it: Wait, how do I take a picture of this one? (4) [two people rowing boats with tree landscape] (5) [Person 1 carries overflowing stack of things to Person 2 in bed] PERSON 1: I brought you honey lemon tea, more pillows, a cinnamon roll, Tylenol, another blanket, a– PERSON 2: It was just Appendicitis, I’m really– PERSON 1: *It is my turn to take care of you and I am going to do it right!* (6) [Two people in car] (7) [still in car) PERSON 1: Oh my god. PERSON 2: Oh my god. (8) [car driving] PERSON 1: Pull over! PERSON 2: I am! (9) [both people get out of car] (10) [Large colored panel of aurora borealis over water with both people looking on] (11) [Person 1 sits against tree while Person 2 lies on the ground] PERSON 1: Fifteen years. No sign of the cancer. (12) I *am* having some weird symptoms. Joint pain. Fatigue. I think I’m losing my close-up vision. PERSON 2: Yeah. Me too. (13) PERSON 2: I think we’re getting old. (14) PERSON 1: I guess that’s okay. PERSON 2: It’s all I wanted.

Comic. Panels up to the 10-year point are grayed out. New panels since the Ten Years comic, which chronicles the first ten years of PERSON 1's journey with cancer: (1) [two people in bed] PERSON 1 (woman): One more chapter? PERSON 2 (man): Don’t we both have to get up early? PERSON 1: Nnnnnggggh PERSON 2: Sure, good point. (2) [many people wearing masks, walking while looking at graphs on their phones] (3) [birds landing on people] PERSON 2 in beanie and scarf: Hah! They like *my* seeds best. PERSON 1 in scarf holding phone with a bird sitting on it: Wait, how do I take a picture of this one? (4) [two people rowing boats with tree landscape] (5) [Person 1 carries overflowing stack of things to Person 2 in bed] PERSON 1: I brought you honey lemon tea, more pillows, a cinnamon roll, Tylenol, another blanket, a– PERSON 2: It was just Appendicitis, I’m really– PERSON 1: *It is my turn to take care of you and I am going to do it right!* (6) [Two people in car] (7) [still in car) PERSON 1: Oh my god. PERSON 2: Oh my god. (8) [car driving] PERSON 1: Pull over! PERSON 2: I am! (9) [both people get out of car] (10) [Large colored panel of aurora borealis over water with both people looking on] (11) [Person 1 sits against tree while Person 2 lies on the ground] PERSON 1: Fifteen years. No sign of the cancer. (12) I *am* having some weird symptoms. Joint pain. Fatigue. I think I’m losing my close-up vision. PERSON 2: Yeah. Me too. (13) PERSON 2: I think we’re getting old. (14) PERSON 1: I guess that’s okay. PERSON 2: It’s all I wanted.

Fifteen Years

xkcd.com/3172/

26.11.2025 22:32 πŸ‘ 11747 πŸ” 2451 πŸ’¬ 289 πŸ“Œ 241