Alan Bince Jacob

The people have spoken and the company is listening. We have reached a public health milestone.
"This moment proves that advocacy, data and courage can change the trajectory of disease.”
www.pdplan.org
www.theguardian.com/environment/...

The generalized Hierarchical Gaussian Filter

elifesciences.org/reviewed-pre...

#stats #cogpsy

A recent @natneuro.nature.com paper analyzed lesion network mapping and raised concerns about the validity of the method.
See below 👇 for our response.

www.biorxiv.org/content/10.6...

We regret to inform you that your paper cannot be considered for publication, but we encourage you to submit it to our GOLD Open Access sister journal

Feedback control of random networks as a model of flexible motor cortical dynamics across tasks Kalidindi and Crevecoeur develop a computational framework linking feedback-controlled networks to limb dynamics. They demonstrate that optimal control of fixed network reproduces key motor cortical d...

Paper is out by @harikalidindi.bsky.social : feedback control model of neural population activity
www.cell.com/cell-reports...

Please share: I am recruiting a PhD student to join my lab in Oslo!

For this project, we will investigate the role of striatal interneurons during action selection, using a combination of behavior, in vivo voltage imaging, and slice ephys.

www.jobbnorge.no/en/available...

#NeuroJobs #NeuroSkyence

Tone deaf af. More AI slop.

Not surprised by this comment. Stinks of ignorance. Comes from a billionaire who’s depending on public money to rebuild a football stadium for a club that he owns partially (28.94%).

Breakthrough @nature.com study showcases new non-invasive treatment for Parkinson’s Disease that targets the somato-cognitive action network (SCAN) with personalized neuromodulation, for superior outcomes. www.nature.com/articles/s41...

PhD Candidate: Cognitive Computational Neuroscience of Memory and Prediction Welcome to Maastricht University! Are you fascinated by how the brain remembers and predicts information, and how it can tell apart representations of past and future? At Maastricht University, you wi...

Job alert 🚨 Fully funded PhD position available in our Maastricht lab! Are you interested in the relationship between memory and prediction, and have a track record of neuroimaging/decoding? Please apply! #NeuroJobs

www.academictransfer.com/nl/jobs/3576...

Wishing you all a happy new year. May this year bring you many success.

Thanks to Sonja Kotz, @auksz.bsky.social, @kennethmeijer.bsky.social, and Markus Köpcke for collaborating with us on this interdisciplinary work.

@maastrichtu.bsky.social

Reduced belief updating impairs adaptive step initiation in older adults Ageing is associated with declines in mobility and balance that threaten independence and increase the risk of falls. Although these changes are often attributed to deterioration of muscular and senso...

✨ My first preprint from my PhD with @tjeerdwboonstra.bsky.social is live ! We reveal reduced precision weighting of prediction errors in older adults during step initiation using Go/No-Go stepping paradigm and Hierarchical Gaussian Filter 👇
doi.org/10.64898/202...

this looks pretty cool from Jirsa lab

"A deformable attractor manifold organizes
human resting-state brain dynamics"
www.biorxiv.org/content/bior...

👏👏

Congratulations Peter

The Nobel Prize committee should announce the World Cup winner tomorrow

During an interesting discussion yesterday with @philosophyshepherd.bsky.social and our Representations Group (www.tcd.ie/Neuroscience...), I mentioned the idea of thinking of our motor systems as embodying a generative model of possible movements. Some members objected...

Stylized logo of the MindBrainBody Symposium

*13th MindBrainBody Symposium*

📆 Mar 9-11, 2026
🏠 #Berlin & virtual
(deadline: Jan 8, 2026)

Keynotes:
- @ulrikebingel.bsky.social
- Karl Friston (online)
- @tinalonsdorf.bsky.social
- Sonja Kotz
- Julian Thayer

...& so much more: prizes, posters, talks, food, drinks, encounters.

Let's meet!

Insular error network enables self-correcting intracranial brain-computer interface Error recognition is fundamental to adaptive behavior, enabling rapid compensatory action when outcomes deviate from expectations. Central to this function are neural circuits for performance monitori...

Insular neural interfaces

Cognitive error signals in the anterior insula propagate toward prefrontal cortex when a BCI fails to follow the user’s intention. Real-time integration enables a self-correcting neural interface that compensates for its own decoder misclassifications

#neuroskyence

New preprint:

Neural manifolds that orchestrate walking and stopping

Here we develop a new theory for neural generation of walking and how it can stop- Next we test the theory using Neuropixels probes in the lumber spinal cord of freely moving rats. See more:

www.biorxiv.org/content/10.1...

Sensory expectations shape neural population dynamics in motor circuits Nature - Experiments with human volunteers and macaques show that expectations produced by probabilistic cueing of future sensory inputs shape motor circuit dynamics in order to increase the...

Thrilled that our paper is out today in Nature!
www.nature.com/articles/s4...

Here at #Indian academy of #neuroscience meeting in the beautiful city of Kovalam in Kerala share.google/EzLqUeTwCeDw... ♥️

@sbaulac.bsky.social is giving the opening talk on brain mosaicism in epilepsy and cortical malformations #epilepsy.

Racist incidents against UK nurses surge by 55% Royal College of Nursing calls on government to stop using anti-migrant rhetoric, which it says emboldens racist behaviour

The Farage Factor.
www.theguardian.com/society/2025...

A Lifetime Member's reflections on making a meaningful career in posture and gait research - ISPGR

We were honoured to award Prof Bradford McFadyen @bjmcfadyen.bsky.social ISPGR's Honorary Membership at our 2025 World Congress. Prof McFadyen reflects on this award - and what it takes to make a meaningful career in posture and gait research - in our latest #ISPGRBlog.
tinyurl.com/5n7ces5h

Results from the HMP estimation on the EEG of participants. The plot shows 5 successive events from stimulus onset to response. The events are represented as topographies at their average time of occurrence in the stimulus response interval.

Revised-TLDR:
Using the hidden multivariate pattern method we show how we capture 5 (!) recurrent EEG topographies in participants' decisions.

We show how these events parse the single-trial reaction time into:
- sensory processes
- attention orientation
- evidence accumulation
- motor execution

April and I finished The Pitt last night, and man...what an amazing show. I can't speak to the medical accuracy, which I've heard is good, but I can speak to the depictions of PTSD/anxiety. I also want to give a shout out to a scene in the final episode between Noah Wyle and Shawn Hatosy that

Started watching The Pitt finally. Hot damn, it’s great. I miss this kind of episodic TV.

Zalsupindole is a Nondissociative, Nonhallucinogenic Neuroplastogen with Therapeutic Effects Comparable to Ketamine and Psychedelics Many neuropsychiatric conditions, including depression, involve synaptic loss and atrophy of the prefrontal cortex. The rapid regrowth of cortical neurons has been hypothesized to explain the rapid an...

Big week for all you second-gen psychedelics and non-hallucinatory neuroplastogens fans! New results from Zalsupindole - promotes greater neuroplasticity than ketamine, psilocybin, or DMT, without any of the pesky psychedelic side (fun?) effects.

pubs.acs.org/doi/abs/10.1...