Great to connect with the membrane protein community at the 6th #APPICOM meeting in south of Paris. Lots of inspiring talks and great discussions. #MembraneProteins #cryoem #nanodiscs #cryoET
Our November issue is available at journals.iucr.org/d/issues/202...
On the cover: recent studies demonstrate that the range of samples suitable for cryo-EM single-particle analysis is expanding towards increasingly more native samples. Read the review at shorturl.at/mitjg
📄 New paper: 3DEM Structure Map Validation Recommendations
Two new metrics assess model-to-map fitness in cryo-EM:
🔹 Q_relative_all → compares avg Q-score across PDB/EMDB
🔹 Q_relative_resolution → compares within similar resolution
#3DEM #CryoEM #wwPDB
Flexibility can be frustrating when processing a #cryoEM dataset. If your target has a wobbly domain, check out our new case study on FaNaC1 for continuous heterogeneity tips in #CryoSPARC!
guide.cryosparc.com/processing-d...
ChimeraX daily builds can predict binding affinity of small molecules using Boltz 2 on your Mac, Windows or Linux computer. www.rbvi.ucsf.edu/chimerax/dat...
#CryoSPARC v4.7 is out! 🚀
Featuring a new automatic Micrograph Junk Detector that labels and rejects contaminants, new tools for curating subsets of particles, performance and stability fixes, and more!
Full changelog: cryosparc.com/updates
#cryoEM
Our publication in Science Advances!
Structural dynamics of a calcium transporter revealed by time-resolved X-ray scattering and cryo-EM in lipid nanodiscs. #CryoEM #membraneprotein #nanodisc #StructuralBiology
www.science.org/doi/10.1126/...
