@sebpfeffer
RNA biologist / Virologist / Principal Investigator / CNRS / Strasbourg / https://ibmc.cnrs.fr/en/laboratoire/arn-en/equipes/rna-regulation-in-viral-infections/ Working on #RNA and #virus. Mostly interested in #RNAi #microRNAs #innateimmunity #arboviruses
Max Fels @mfels.bsky.social from our lab discovers giant DNA viruses that infect amoeba encode eIF4E and the entire suite of 4F complex proteins to control mRNA translation, including beautiful crystal structures of viral 4E bound to modified mRNA 5' caps:
www.cell.com/cell/fulltex...
Don't miss this great opportunity!
Group Leader Call at the @cbitoulouse.bsky.social in
Genome biology, projects at the interface with devbio will be given particular attention. please share :)
cbi-toulouse.fr/wp-content/u...
#PressRelease🗞️ A specific molecular mechanism has been identified as the cause of the most frequent genetic forms of amyotrophic lateral sclerosis (ALS, also known as Charcot’s disease) and frontotemporal dementia (FTD).
👉 www.cnrs.fr/en/press/discov...
Now out in Nature! We visualize infection of the RNA virus RSV in real-time with single-vRNP resolution to understand how RSV establishes viral factories, biomolecular condensates that act as sites of viral replication. A huge collaborative effort led by Dhanushika Ratnayake!
rdcu.be/e1bBW
Au terme d'une analyse totalement déconnectée de la réalité dont les crânes d'oeuf de Bercy ont le secret, Le gouvernement en déduit qu'il peut récupérer 1,4 milliards d'euros (sur 2,5) sur le dos des universités et de l'ANR principalement.
![dsRNA injection to N. vectensis zygotes triggers mild and transient gene knockdown. Top: Schematic representation of the dsRNA carrying eGFP sequence used in this study and of the transgene of the actin::eGFP line [40]. Bottom left: Heterozygous actin::eGFP embryos showing dimmer eGFP fluorescence 24 hpi of dsRNA carrying eGFP sequence (left) compared to scrambled eGFP sequence (right). Scale bars represent 500 µm. Bottom right: No difference in eGFP fluorescence of heterozygous actin::eGFP embryos is exhibited 72 hpi of dsRNA carrying eGFP sequence (left) compared to scrambled eGFP sequence (right). Scale bars represent 500 µm.](https://cdn.bsky.app/img/feed_thumbnail/plain/did:plc:5522ztebtekoor5efelihqhb/bafkreibcytm7tkd5lfkqqb3opea5ptwopbn3yzlw633irru3v6eq2azxtq)
dsRNA injection to N. vectensis zygotes triggers mild and transient gene knockdown. Top: Schematic representation of the dsRNA carrying eGFP sequence used in this study and of the transgene of the actin::eGFP line [40]. Bottom left: Heterozygous actin::eGFP embryos showing dimmer eGFP fluorescence 24 hpi of dsRNA carrying eGFP sequence (left) compared to scrambled eGFP sequence (right). Scale bars represent 500 µm. Bottom right: No difference in eGFP fluorescence of heterozygous actin::eGFP embryos is exhibited 72 hpi of dsRNA carrying eGFP sequence (left) compared to scrambled eGFP sequence (right). Scale bars represent 500 µm.
#RNAi is an ancestral #antiviral system that degrades viral RNA, but what about in #cnidarians? @yehumoran.bsky.social &co show that #Nematostella has an siRNA-mediated antiviral response that lacks 2ary amplification & functions as a short-term antiviral mechanism @plosbiology.org 🧪 plos.io/3N192OD
Our latest paper on bat Dicer! 🦇 we show that Dicer antiviral RNAi activity is context-dependent also in bats 👩🔬 Specifically in Myotis myotis nasal epithelial cells, Dicer relocalizes to sites of viral replication upon alphavirus infection, which correlates with a proviral activity of Dicer 🦠
Just in time for Christmas, here is the latest paper from the lab! Great work from @leagaucherand.bsky.social and Hugo Marie, with help from Julie Cremaschi. Funded by @frm-officiel.bsky.social, @agencerecherche.bsky.social
journals.plos.org/plospathogen...
@cnrsbiologie.bsky.social @unistra.fr
Léa and Hugo celebrate their paper by opening a bottle of crémant
The lab gathered at a restaurant table
Group photo in front of the christmas market entrance
Yesterday was a good day for the lab with a paper accepted (congrats @leagaucherand.bsky.social and Hugo Marie !) and a very nice Christmas dinner 🎅
[ #VeilleESR #LPPR ] Pour fêter ses 20 ans, le gouvernement envisage de baisser le budget de l'@agencerecherche.bsky.social
@claire-giry.bsky.social par @antoinebeau.bsky.social et @stephaniebenz.bsky.social
How does fever work?
Our new Science paper shows how elevated body temperature can protect against severe influenza and that avian-origin viruses escape this defence.
This is likely one reason why bird flus and some pandemic influenzas can be so severe.🧵
www.science.org/doi/10.1126/...
#RejoignezLeCNRS 🫵 Les concours chercheurs CNRS 2026 ouvrent le 8/12 !
Envie de faire avancer la science au sein d’un des plus grands organismes de recherche ?
👉 carrieres.cnrs.fr/concours-...
#ConcoursChercheurs #Science #Recherche #Icicarecrute #recrutement
BIG ANNOUNCEMENT📣: I haven’t been this excited to be part of something new in 15 years… Thrilled to reveal the passion project I’ve been working on for the past year and a half!🙀🥳 (thread 👇)
Are bats tolerant of all viruses? With a comparative -omics approach, we show that Egyptian fruit bat cells show both antiviral and pro-inflammatory immune responses to infection with Zika virus while our Jamaican fruit bat cells are not susceptible.
www.biorxiv.org/content/10.1...
BREAKING: Friday night massacre underway at CDC. Doznes of "disease detectives," high-level scientists, entire Washington staff and editors of the MMWR (Morbidity and Mortality Weekly Report) have all been RIFed and received the following notice:
Today my @nytimes.com colleagues and I are launching a new series called Lost Science. We interview US scientists who can no longer discover something new about our world, thanks to this year‘s cuts. Here is my first interview with a scientist who studied bees and fires. Gift link: nyti.ms/3IWXbiE
This was an interesting read.
cmarmitage.substack.com/p/i-research...
After years in the making, Joe McKellar @viroscope.bsky.social’s final PhD paper is finally out today in PNAS! 🎉 🎉🎉
www.pnas.org/doi/10.1073/...
Want to connect with researchers in #GeneRegulation, small RNAs, #StructuralBiology and more? Sign up for EMBO Workshop "RNA-guided genome protection" in Caux, Switzerland, 16–20 June 2026!
Deadline: 15 March
meetings.embo.org/event/26-gen...
#DNAsky #RNAsky #EMBORNAGenomeProtection #EMBOevents 🧪
@alphaerika.bsky.social @cmeignin.bsky.social @lucievirevolte.bsky.social @leagaucherand.bsky.social @emiliebrasset.bsky.social @deborahbourchis.bsky.social @merklinglab.bsky.social @carogoujon.bsky.social
and thank you @alphaerika.bsky.social, who was the co-supervisor of Charline's work!
Photo of Charline and her jury members after the defense
Today was a great day for Charline Pasquier, who successfully defended her PhD thesis in front of the jury composed of @annemarthe.bsky.social @ericci-aeruginosa.bsky.social, Stefania Millevoi and Jean-Luc Imler. Congratulations to her for a brilliant defense! 🍾
Today @nature.com
www.nature.com/articles/d41...
Genome-wide mapping of RNA-protein associations through sequencing go.nature.com/4gmf1Ii
Phages, viruses that infect bacteria, could help fight antibiotic resistance, but phage–host interactions are not yet sufficiently understood. Researchers from #HIRI, JMU & HZI now successfully interfered with phage reproduction using ASOs.
Just out in @nature.com:
www.nature.com/articles/s41...
Our work on the function of miR-51/miR-100 is out! miR-100 is widely conserved across eumetazoans but its function has been mysterious. Emilio Santillán found in worms it regulates signaling and extracellular matrix genes, some of which seem to be conserved targets! www.science.org/doi/10.1126/...
