CIRTN-R2FIC

STARD10 regulates human pancreatic β cell differentiation and triglyceride metabolism Teo and colleagues uncovered the role of T2D-associated STARD10 lipid transfer protein in human beta cells. They found STARD10 to be important for proliferation and INS+ beta cell formation. Loss of S...

(🧵7/7) From the first half of February 2026.
From Dr: Guy Rutter:
“STARD10 regulates human pancreatic β cell differentiation and triglyceride metabolism”
PMID: 41687621
www.cell.com/stem-cell-re...

(🧵6/7) From the first half of February 2026.
From Dr: Guy Rutter:
“MTFP1 preserves β-cell cristae structure and bioenergetics to ensure insulin release and glucose homeostasis”
PMID: 41648185
www.biorxiv.org/content/10.6...

In vivo functional profiling and structural characterization of the human GLP1R A316T variant The GLP1R A316T missense variant displays improved glucose tolerance but impaired pharmacological incretin responses in vivo.

(🧵5/7) From the first half of February 2026.
From Dr: Guy Rutter:
“In vivo functional profiling and structural characterization of the human GLP1R A316T variant”
PMID: 41637494
www.science.org/doi/10.1126/...

Sage Journals: Discover world-class research Subscription and open access journals from Sage, the world's leading independent academic publisher.

(🧵4/7) From the first half of February 2026.
From Dr: Michael Riddell:
“Potential Applications of Inhaled Insulin in Diabetic Ketoacidosis Prevention and During Exercise: Two Case Presentations”
PMID: 41622414
journals.sagepub.com/doi/10.1177/...

Case Reports: Practical Use of Pulmonary Inhaled (Technosphere) Insulin in Type 1 Diabetes, Type 2 Diabetes, and Pregnancy - Irl B. Hirsch, Thomas C. Blevins, Amy M. Valent, Michael C. Riddell, 2026 Limitations in current insulin formulations contribute to suboptimal glycemic control and increased risks of hypoglycemia and hyperglycemia. Afrezza® with Techn...

(🧵3/7) From the first half of February 2026.
From Dr: Michael Riddell:
“Case Reports: Practical Use of Pulmonary Inhaled (Technosphere) Insulin in Type 1 Diabetes, Type 2 Diabetes, and Pregnancy”
PMID: 41622409
journals.sagepub.com/doi/10.1177/...

Lipidomic Analysis of Plasma Extracellular Vesicles from Adiponectin Deficient Mice or Metabolic Syndrome Patients Reveals Pro‐Oxidative and Pro‐Inflammatory Lipid Signatures Correlating with Metabolic Dysfunction Adiponectin deficiency remodels the lipid composition of plasma extracellular vesicles (EV), enriching polyunsaturated phospholipids and reducing lysophospholipids. These remodelled EV impact oxidati...

(🧵2/7) From the first half of February 2026.
From Dr. Kacey Prentice:
“Lipidomic Analysis of Plasma Extracellular Vesicles from Adiponectin Deficient Mice or Metabolic Syndrome Patients...”
PMID: 41656969
isevjournals.onlinelibrary.wiley.com/doi/10.1002/...

(🧵1/7) Several publications coming out of CIRTN labs in the first half of February 2026🎉! This includes labs of Drs: Prentice, Riddell and Rutter.

Islet amyloid disrupts MHC class II antigen presentation and delays autoimmune diabetes in NOD mice - Diabetologia Aims/hypothesis Islet amyloid contributes to beta cell failure in type 2 diabetes through several mechanisms, one being the potent induction of local islet inflammation through activating inflammatory...

(🧵23/23) Jan 2026:
From Dr. Bruce Verchere:
"Islet amyloid disrupts MHC class II antigen presentation and delays autoimmune diabetes in NOD mice"
PMID: 41423547
link.springer.com/article/10.1...

B cells drive CD4 T cell immunosenescence and age-associated health decline B cells promote CD4 T cell aging and decline in health-span parameters through intercellular communication and nutrient sensing.

(🧵22/23) Jan 2026:
From Drs. Sue Tsai and Minna Woo:
"B cells drive CD4 T cell immunosenescence and age-associated health decline"
PMID: 41616067
www.science.org/doi/10.1126/...

Reduced fibre-fermenting capacity of gut microbes in multiple sclerosis may result in prebiotic dietary fibre β-fructan promoting inflammation and CNS damage Background Some people with multiple sclerosis display changes in their gut microbiota with separate evidence suggesting that symptoms may worsen following a high-fibre diet. We hypothesised that in p...

(🧵21/23) Jan 2026:
From Dr. Sue Tsai:
"Reduced fibre-fermenting capacity of gut microbes in multiple sclerosis may result in prebiotic dietary fibre β-fructan promoting inflammation and CNS damage"
PMID: 41585377
egastroenterology.bmj.com/content/4/1/...

ER calcium stores contribute to glucose-induced Ca2+ waves and intercellular connectivity in mouse pancreatic islets Defective insulin secretion is a hallmark of diabetes mellitus. Glucose-induced Ca2+ oscillations are critical for the stimulation of insulin secretio…

(🧵20/23) Jan 2026:
From Dr. Guy Rutter:
"ER calcium stores contribute to glucose-induced Ca2+ waves and intercellular connectivity in mouse pancreatic islets"
PMID: 41418583
www.sciencedirect.com/science/arti...

Frontiers | Effects of protein intake on glucagon, insulin, and glucose dynamics: implications for diabetes Carbohydrates are the main macronutrient of interest for dosing insulin and managing glycemia in type 1 diabetes (T1D) due to their direct impact on blood gl...

(🧵19/23) Jan 2026:
From Dr. Michael C Riddell:
"Effects of protein intake on glucagon, insulin, and glucose dynamics: implications for diabetes"
PMID: 41602572
www.frontiersin.org/journals/cli...

Prolonged Somatostatin Receptor 2 Antagonism Enhances Glucagon Response to Hypoglycemia in Male Diabetic Rats Abstract. In diabetes, glucagon is typically oversecreted during hyperglycemia but undersecreted during hypoglycemia. Administration of a somatostatin rece

(🧵18/23) Jan 2026:
From Dr. Michael C Riddell:
"Prolonged Somatostatin Receptor 2 Antagonism Enhances Glucagon Response to Hypoglycemia in Male Diabetic Rats"
PMID: 41502124
academic.oup.com/endo/article...

Adolescents With Type 1 Diabetes Using Dapagliflozin as an Adjunct-to-Insulin: Perspectives on Experiences of Clinical Trial Participation The Adolescent Type 1 diabetes Treatment with SGLT2i for hyperglycEMia & hyPerfilTration (ATTEMPT) study evaluated the impact of sodium-glucose cotransporter-2 inhibitors (SGLT2i) as an adjunct-to-ins...

(🧵17/23) Jan 2026:
From Dr. Michael C Riddell:
"Adolescents With Type 1 Diabetes Using Dapagliflozin as an Adjunct-to-Insulin: Perspectives on Experiences of Clinical Trial Participation"
PMID: 41482084
www.endocrinepractice.org/article/S153...

Systematic Review of Continuous Glucose Monitor Accuracy in the Hypoglycemia Range for Non-Critical Care Ward Hospitalized People Living With Diabetes - Nicole Prince, Timothy Ramsay, Risa Shorr, Rémi... In-hospital standard of care for people living with diabetes (PLWD) is based on capillary blood glucose to activate hypoglycemia treatment protocols. PLWD on no...

(🧵16/23) Jan 2026:
From Dr. Rémi Rabasa-Lhoret:
"Systematic Review of Continuous Glucose Monitor Accuracy in the Hypoglycemia Range for Non-Critical Care Ward Hospitalized People Living With Diabetes"
PMID: 41618962
journals.sagepub.com/doi/10.1177/...

(🧵15/23) Jan 2026:
From Dr. Rémi Rabasa-Lhoret:
"Association between daily steps, diabetes management and health indicators in people living with type 1 diabetes: A cross-sectional study from the BETTER registry"
PMID: 41555836
dom-pubs.pericles-prod.literatumonline.com/doi/10.1111/...

Screening for Fear of Hypoglycemia in Type 1 Diabetes: Aligning Clinical Practice with Current Guidelines Recent clinical guidelines recommend screening for fear of hypoglycemia (FOH) as it is a known barrier in type 1 diabetes (T1D) management. Thus, this study proposes a one-item screening question to i...

(🧵14/23) Jan 2026:
From Dr. Rémi Rabasa-Lhoret:
"Screening for Fear of Hypoglycemia in Type 1 Diabetes: Aligning Clinical Practice with Current Guidelines"
PMID: 41547387
www.endocrinepractice.org/article/S153...

(🧵13/23) Jan 2026:
From Dr. Rémi Rabasa-Lhoret:
"A systematic review of glucocorticoid use in type 1 diabetes: Glycaemic effects and clinical management strategies"
PMID: 41521936
dom-pubs.pericles-prod.literatumonline.com/doi/10.1111/...

(🧵12/23) Jan 2026:
From Dr. Rémi Rabasa-Lhoret:
"The spectrum of exogenous insulin requirement in people living with type 1 diabetes: A cross-sectional analysis"
PMID: 41521907
dom-pubs.pericles-prod.literatumonline.com/doi/10.1111/...

Impacts of ketogenic diet intervention on cardiometabolic outcomes in obese, dysglycemic mice - Cardiovascular Diabetology Background The ketogenic diet (KD) is widely recognized for its potential benefits in individuals with type 2 diabetes, but findings from both human and animal studies remain inconsistent. Type 2 diab...

(🧵11/23) Jan 2026:
From Dr. Erin Mulvihill:
"Impacts of ketogenic diet intervention on cardiometabolic outcomes in obese, dysglycemic mice"
PMID 41484888
link.springer.com/article/10.1...

Adipocyte‐specific ablation of plakoglobin in mice does not affect adiposity but results in sexual‐dimorphic effects on weight gain The main transcriptional coactivator of the WNT pathway, β-catenin, is a well-established regulator of adipogenesis and fat expansion, but our knowledge of how other members of the catenin family par...

(🧵10/23) Jan 2026:
From Dr. Gareth Lim:
"Adipocyte-specific ablation of plakoglobin in mice does not affect adiposity but results in sexual-dimorphic effects on weight gain"
PMID: 41451973
physoc.onlinelibrary.wiley.com/doi/10.14814...

Tunable differentiation of human CD4+ and CD8+ T cells from pluripotent stem cells Jones et al. demonstrate that Notch signaling suppresses CD4+ (helper) T cell induction from PSCs and that manipulating TCR and Notch signaling enables control over CD4+ vs. CD8+ (cytotoxic) T cell pr...

(🧵9/23) Jan 2026:
From Dr. Megan K Levings:
"Tunable differentiation of human CD4+ and CD8+ T cells from pluripotent stem cells"
PMID: 41512836
www.cell.com/cell-stem-ce...

Application of a thermoelectric cooling approach for localized hypothermia in a murine model Achieving localized and adjustable hypothermia is critical for various clinical and experimental applications, including reducing oxidative stress, mo…

(🧵8/23) Jan 2026:
From Drs. Andrew Pepper and Greg Korbutt:
"Application of a thermoelectric cooling approach for localized hypothermia in a murine model"
PMID: 41492409
www.sciencedirect.com/science/arti...

(🧵7/23) Jan 2026:
From Dr. Rebecca L Hull-Meichle:
"Single cell and spatial characterization of the human pancreas reveals drivers of beta cell dysfunction in cystic fibrosis"
PMID: 41446239
www.biorxiv.org/content/10.6...

AMPK at the interface of nutrient sensing, metabolic flux and energy homeostasis - Nature Metabolism In this Review, Smith et al. summarize the most recent findings on AMPK and emphasize its role as a nutrient sensor and in regulating metabolic homeostasis, as well as how AMPK dysregulation contribut...

(🧵6/23) Jan 2026:
From Dr. Morgan Fullerton:
"AMPK at the interface of nutrient sensing, metabolic flux and energy homeostasis"
PMID: 41526585
www.nature.com/articles/s42...

(🧵5/23) Jan 2026:
From Dr. Mourad Ferdaoussi:
"Ketone therapy prevents semaglutide-induced loss of cardiac mass"
PMID: 41026893
academic.oup.com/eurjpc/artic...

Associations between serum PFAS concentrations and beta cell function and insulin resistance in adult females AbstractContext. Epidemiological evidence of exposure to precursor and alternative, per- and polyfluoroalkyl substances (PFAS) and metabolic health outcome

(🧵4/23) Jan 2026:
From Dr. Jenny Bruin:
"Associations between serum PFAS concentrations and beta cell function and insulin resistance in adult females"
PMID 41554111
academic.oup.com/jcem/advance...

Modelling the Spectrum of Type 2 Diabetes in Mice Abstract. Type 2 diabetes (T2D) is a heterogenous metabolic condition characterized by varying degrees of insulin resistance and β-cell dysfunction. Precli

(🧵3/23) Jan 2026:
From Drs. Jenny Bruin and Jennifer Estall:
"Modelling the Spectrum of Type 2 Diabetes in Mice"
PMID: 41527917
academic.oup.com/endo/advance...

Generation and validation of an aryl hydrocarbon receptor knockout human embryonic stem cell line Abstract. Glucose homeostasis is tightly controlled by hormones secreted from pancreatic islets. The most abundant cell type in islets is the β-cell, which

(🧵2/23) Jan 2026:
From Drs. Jenny Bruin and Francis Lynn:
"Generation and validation of an aryl hydrocarbon receptor knockout human embryonic stem cell line"
PMID: 41502145
academic.oup.com/endo/advance...

(🧵1/23) First month of 2026: complete✅! Many papers coming from CIRTN scientists, including works from the labs of Drs Bruin, Lynn, Estall, Ferdaoussi, Fullerton, Hull-Meichle, Pepper, Korbutt, Levings, Lim, Mulvihill, Rabasa-Lhoret, Riddell, Rutter, Tsai, Woo and Verchere! 📝