Nature Aging

Multi-tissue transcriptomic aging atlas reveals predictive aging biomarkers in the killifish - Nature Aging Characterizing molecular aging features is crucial for understanding systemic and local factors contributing to the aging process. Here Costa, Chen et al. performed RNA sequencing on 13 tissues across...

Online now! Costa, Chen et al. performed RNA-seq on 13 tissues, six ages in male and female African turquoise killifish. The Killifish Aging Atlas provides a comprehensive resource for aging studies. @emkcosta.bsky.social @jingxunchen.bsky.social @brunetlab.bsky.social
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Estropausal gut microbiota transplant improves measures of ovarian function in adult mice - Nature Aging To investigate the link between the gut microbiome and ovarian health, here the authors transplant gut microbiota from estropausal female mice to young adult female mice. Microbial transplantation imp...

Online now! A new study shows transplanting gut microbiota from estropausal female mice to young adult female mice improves ovarian hormone profiles, follicle metrics, and fertility-related outcomes. @bbparis1984.bsky.social
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📸On the cover: the Chinese hero archer Hou Yi, who, according to legend, saved the Earth from scorching heat, is depicted as quenching inflammation

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🗞️Our February issue is live! Read work on precision responses to therapy-induced senescence, senolytic resistance mechanisms, AD biomarkers in Latin America, the exposure of older adults to health misinformation, links from DNA damage in macrophages to autoimmunity & more ✨

Induction of senescence during postpartum mammary gland involution supports tissue remodeling and promotes postpartum tumorigenesis - Nature Aging Chiche, Djoual, Charifou and colleagues identify a dual role for cell senescence in postpartum tissue remodeling: senescent cells drive mammary gland involution, yet create a permissive niche for tumo...

Online now! ✨Chiche, Djoual, Charifou et al identify a dual role for senescence in postpartum tissue remodelling: senescent cells drive mammary gland involution, yet predispose to postpartum tumor initiation @hanli-pasteur.bsky.social @pasteur.fr

Targeting age-related LINE-1 activation alleviates cardiac aging - Nature Aging LINE-1 retrotransposons are implicated in aging, but their role in cardiac aging specifically is not well understood. Here the authors show that LINE-1 expression rises in mouse hearts with age. Genet...

Online now! Study shows LINE-1 is increasingly expressed in mouse hearts with age, its de-repression is accompanied by cGAS-STING activation and cardiac dysfunction, while pharmacological inhibition of LINE-1 or STING improves cardiac function in aged mice. (rdcu.be/e0JU0)

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Lysophosphatidylcholines are associated with amyloidosis in early stages of Alzheimer’s disease - Nature Aging Kalia et al. investigate metabolic changes in Alzheimer’s disease (AD) using blood metabolomics, and show that lysophosphatidylcholines are associated with early amyloidosis in AD as measured by P-tau...

Online now! Kalia et al. investigate metabolic changes in Alzheimer’s disease (AD) using blood metabolomics, and show that lysophosphatidylcholines are associated with early amyloidosis in AD as measured by P-tau181 and P-tau217.
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Reprogramming the GRHL2−CDK19 axis by gene therapy alleviates prostate aging - Nature Aging The prostate is an important part of the male reproductive system whose aging process is incompletely understood. Sun et al. identify GRHL2 downregulation as a driver of prostate aging. They show that...

Online now! Sun et al. identify GRHL2 downregulation as a driver of prostate aging. They show GRHL2 transactivates CDK19 to inhibit p53-p21 signaling, and demonstrate that GRHL2 gene therapy alleviates age-related urinary dysfunction in mice. (rdcu.be/e0fbZ)
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Integrating polygenic signals and single-cell multiomics identifies cell-type-specific regulomes critical for immune- and aging-related diseases - Nature Aging In this technical report Ma et al. present scMORE, a polygenic method integrating single-cell multiomics and GWAS to prioritize cell-type-specific, trait-relevant eRegulons. scMORE revealed regulators...

Online now! Ma et al. present scMORE, a polygenic method integrating single-cell multiomics and GWAS to prioritize cell-type-specific, trait-relevant eRegulons.
doi.org/10.1038/s435...

📸On the cover: a cloth woven from multicolored threads, in which the roman numeral V emerges, represents the journal’s vision of bringing together aging research from different corners of the field

🗞️In our January issue, we celebrate the 5th anniversary of Nature Aging 🎉Read one Q&A from aging researchers, another Q&A to peek behind the scenes at the journal, our reflections on the past 5 years, and lots of great science too, here: nature.com/nataging/vol...

🗞️Our December issue is live, featuring the identification of age-related cell states in breast cancer on the cover!📷The issue also includes work on ECM aging, somatic mutations, epigenetic drift, intrinsic capacity and much more. Read it all here: nature.com/nataging/vol...

🗞️Our November issue is live, featuring multilingualism and healthy aging on the cover!📷The issue also includes work on biomarkers of aging, clinical interventions, the interplay between cancer and aging, and much more. Read it all here: www.nature.com/nataging/vol...

Aging represses oncogenic KRAS-driven lung tumorigenesis and alters tumor suppression - Nature Aging The mechanisms that impact tumorigenesis during aging are incompletely understood. Here Shuldiner et al. show that in mice, aging represses KRAS-driven lung tumorigenesis and dampens the impact of ina...

Online now! Emily Shuldiner et al. show that in mice, aging represses KRAS-driven lung tumorigenesis and dampens the impact of inactivating many tumor suppressor genes
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A versatile cohesion manipulation system probes female reproductive age-related egg aneuploidy - Nature Aging To study pathways that lead to aneuploidy during aging, the authors provide a system that enables cohesion protein depletion in mouse oocytes, mimicking effects that occur during aging. They uncover a...

Online now! @binyammogessie.bsky.social, @jiyeonleem.bsky.social and colleagues provide a system that enables cohesion protein depletion in mouse oocytes, probing reproductive age-related egg aneuploidy.
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Hospital-treated infectious diseases and the risk of epilepsy in older age - Nature Aging Infectious diseases can cause acute seizures. Here the authors investigate their long-term impact on the risk of epilepsy for older adults. They find that hospital-treated infectious diseases have a l...

Online now! A new study shows that hospital-treated infectious diseases have a lasting impact on the development of epilepsy in older age, and that cardiovascular risk factors may exacerbate this impact.
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Cell populations in human breast cancers are molecularly and biologically distinct with age - Nature Aging Parsons and colleagues characterize age-associated changes in the tumor microenvironment of triple-negative and estrogen receptor-positive breast cancer using computational analysis of transcriptomic ...

Online now!✨Parsons et al profile age-associated changes in the tumor microenvironment of triple-negative and estrogen receptor-positive breast cancer nature.com/articles/s43... rdcu.be/eOc8t @vangalenlab.bsky.social @sandramcallister.bsky.social @mgbresearch.bsky.social @harvardmed.bsky.social

Heme and iron toxicity in the aged spleen impairs T cell immunity through iron deprivation - Nature Aging In their study, Ezuz et al. show that the aged spleen contributes to T cell aging through hemolytic stress and an increasingly heme- and iron-rich microenvironment. T cells adapt by limiting their iro...

Online now! In their study, Ezuz et al. show that the aged spleen contributes to T cell aging through hemolytic stress in a heme- and iron-rich microenvironment.
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Genome-wide analysis of brain age identifies 59 associated loci and unveils relationships with mental and physical health - Nature Aging This genomic study of magnetic resonance imaging-based brain age in 56,348 people identifies 59 genetic loci, links brain aging to mental and physical health, and suggests high blood pressure and type...

Genomic study of brain age in 56,348 people identifies 59 genetic loci, links brain aging to mental and phys health, and suggests high blood pressure and T2D as causal factors of brain aging #brainage @pjawinski.bsky.social @humboldtuni.bsky.social @mpicbs.bsky.social www.nature.com/articles/s43...

Targeting iron-associated protein Ftl1 in the brain of old mice improves age-related cognitive impairment - Nature Aging The authors identify ferritin light chain 1 (FTL1), an iron-associated protein, as a pro-aging neuronal factor that increases with age and promotes cognitive decline. Targeting FTL1 in the brain impro...

In our October issue: Ferritin light chain 1 (FTL1), an iron-associated protein, is a pro-aging neuronal factor that increases with age and promotes cognitive decline. Targeting FTL1 in the brain improved cognition in old mice @VilledaLab @ucsfaging.bsky.social @UCSF www.nature.com/articles/s43...

🗞️Our October issue is live!📷This month, we're featuring work on regulators of cognitive decline, senescence – immune interplay, herb-derived geroprotectors and more. Read it all here: nature.com/nataging/vol...

Elastin-derived extracellular matrix fragments drive aging through innate immune activation Nature Aging - The contribution of the extracellular matrix and its degradation to the aging process is not well understood. Here, the authors show that degraded elastin fragments, which increase...

Online now! A new study shows that degraded elastin fragments, which increase in the circulation over time, promote aging. Counteracting elastin fragment signals alleviates inflammation, promotes healthy aging, and extends lifespan. (rdcu.be/eITno) doi.org/10.1038/s435...

🗞️Our September issue is live!📷This month, we're featuring work on somatic mutations, clocks, and more. Read it all here: nature.com/nataging/vol...

The X-Age Project to construct a Chinese aging clock Nature Aging - In this Perspective, members of the Aging Biomarker Consortium outline the X-Age Project, an Aging Biomarker Consortium plan for building standardized aging clocks in China. The...

Online now! In this Perspective members of the Aging Biomarker Consortium (ABC) outline the X-Age project, an ABC plan for building standardized aging clocks in China. (rdcu.be/eGFV0)
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A blood-based DNA damage signature in patients with Parkinson’s disease is associated with disease progression - Nature Aging Aging is a risk factor for Parkinson’s disease; however, how DNA damage accumulation, a hallmark of aging, contributes to its pathophysiology remains incompletely understood. Here, the authors identif...

Online now! Study identifies a blood-based DNA damage signature in Parkinson’s disease patients that associates with disease progression. (rdcu.be/eES51)
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🎉 We’re thrilled to present our August issue, which includes a Focus on immune aging! 🎉Here, you’ll find a series of reviews and opinion pieces on recent advances in immune aging research nature.com/nataging/vol... 🎨by Alex Whitworth

The aging factor EPS8 induces disease-related protein aggregation through RAC signaling hyperactivation - Nature Aging Aging is a risk factor for neurodegenerative diseases associated with protein aggregation. Here the authors identify age-related hyperactivation of EPS8/RAC signaling in C. elegans as a driver of path...

Online now! @thevilchezlab.bsky.social @sedakoyuncu.bsky.social identify age-related hyperactivation of EPS8/RAC signaling in C.elegans as a driver of pathological protein aggregation, highlighting EPS8 and its regulators as potential therapeutic targets.
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Large-scale genome-wide analyses with proteomics integration reveal novel loci and biological insights into frailty - Nature Aging To better understand the etiology of frailty, the authors perform a large genetic study. They identified 45 additional variants and implicated MET, CHST9, ILRUN, APOE, CGREF1 and PPP6C as potential ca...

Online now! A genetic study of frailty identifies 45 additional variants and implicates MET, CHST9, ILRUN, APOE, CGREF1 and PPP6C as potential causal genes, linking frailty to immune regulation, metabolism, and cellular signaling.
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Serum amyloid P secreted by bone marrow adipocytes drives skeletal amyloidosis Nature Aging - Amyloid fibrils can accumulate in tissues outside the brain, yet the impact is incompletely understood. Here the researchers show that, with age, mouse bone marrow fat cells become...

Online now! A new study shows that with age bone marrow fat cells become senescent and secrete SAP/PTX2, driving amyloid buildup and bone loss. (rdcu.be/ezbVV)
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