JAMA Cardiology

JAMA Cardiology editorial: "Opposing Results From 2 Trials Comparing Conduction System Pacing and Biventricular Pacing" by Jens Cosedis Nielsen et al. Published online March 11, 2026. doi: 10.1001/jamacardio.2026.0097.

💬 Editorial: HeartSync-LBBP found #CSP superior to #BiVP for heart failure outcomes, whereas PhysioSync-HF found CSP inferior, emphasizing the importance of patient selection and operator proficiency.

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JAMA Cardiology presents an RCT on conduction system vs biventricular pacing in heart failure. Population: 87 men, 86 women. Intervention: 173 participants. Findings include all-cause death, HF hospitalization, and LVEF increase rates.

In patients with #HeartFailure and #LBBB, conduction system pacing (#CSP) was inferior to biventricular pacing (#BiVP) for a composite of death, heart failure events, and LVEF change at 12 months.

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JAMA Cardiology infographic shows research on heart failure outcomes. Study of 200 participants (136 men, 64 women) randomized into LBBP and BiVP treatment groups. LBBP group had lower risk of mortality. Hazard ratio: text@1.

Among patients with heart failure and LBBB, LBBP demonstrated superior long-term clinical outcomes compared to BiVP, driven primarily by reduced rates of heart failure hospitalization.

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Density plot of maximum LDL-C values and regression model of cardiovascular phenotypes. Plot A compares FH and Noncarrier LDL-C, while plot B shows odds ratios for phenotypes like ASCVD, CAD, PAD, TIA, Hypertension, Obesity, Diabetes and Smoking.

Genotype-positive #FamilialHypercholesterolemia in US adults was linked to higher atherosclerotic cardiovascular disease rates and lower achievement of guideline-recommended LDL-C targets.

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Density plot comparing max LDL-C values in FH vs. noncarriers. Regression model shows cardiovascular phenotypes like ASCVD, CAD, PAD, TIA, Hypertension, Obesity, Diabetes, Smoking; OR values range from 1 to 4. FH peaks around 200, noncarrier around 100.

Genotype-positive #FamilialHypercholesterolemia in US adults was linked to higher atherosclerotic cardiovascular disease rates and lower achievement of guideline-recommended LDL-C targets.

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Restricted Cubic Splines Displaying Associations Between Aldosterone-Renin Ratio and Risk of Cardiovascular Outcomes; includes five graphs of ratio vs. incidence of AF, ischemic stroke, HF, MI, & composite outcome. Each graph shows an aHR value.

Higher aldosterone-renin ratios in older adults were linked to increased risk of atrial fibrillation and ischemic stroke, supporting the aldosterone pathway as a target for cardiovascular disease prevention.

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Density plot of maximum recorded LDL-C values in Genotype-Positive Familial Hypercholesterolemia (FH) & regression model of cardiovascular phenotypes. Density shows FH & Noncarrier LDL-C levels. Regression plots ASCVD, CAD, PAD, TIA, & other phenotypes.

Genotype-positive #FamilialHypercholesterolemia in US adults was linked to higher atherosclerotic cardiovascular disease rates and lower achievement of guideline-recommended LDL-C targets.

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Restricted Cubic Splines Displaying Associations Between Aldosterone-Renin Ratio and Risk of Cardiovascular Outcomes; includes five graphs of ratio vs. incidence of AF, ischemic stroke, HF, MI, & composite outcome. Each graph shows an aHR value.

Higher aldosterone-renin ratios in older adults were linked to increased risk of atrial fibrillation and ischemic stroke, supporting the aldosterone pathway as a target for cardiovascular disease prevention.

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Four graphs show cumulative incidence of events over 20 years after patent foramen ovale closure. A: All-cause death rises to 15.4%. B: Stroke events reach 0.8%. C: Stroke/TIA events rise to 4.6%. D: New-onset atrial fibrillation reaches 6.9%.

At 20-year follow-up after patent foramen ovale closure for paradoxical embolism, recurrent stroke was rare (<1%), while bleeding events occurred in 13% and were more frequent among women and those on long-term antithrombotic therapy.

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Four graphs show cumulative incidence of events over 20 years after patent foramen ovale closure. A: All-cause death rises to 15.4%. B: Stroke events reach 0.8%. C: Stroke/TIA events rise to 4.6%. D: New-onset atrial fibrillation reaches 6.9%.

At 20-year follow-up after patent foramen ovale closure for paradoxical embolism, recurrent stroke was rare (<1%), while bleeding events occurred in 13% and were more frequent among women and those on long-term antithrombotic therapy.

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Four graphs show cumulative incidence of events over 20 years after patent foramen ovale closure. A: All-cause death rises to 15.4%. B: Stroke events reach 0.8%. C: Stroke/TIA events rise to 4.6%. D: New-onset atrial fibrillation reaches 6.9%.

At 20-year follow-up after patent foramen ovale closure for paradoxical embolism, recurrent stroke was rare (<1%), while bleeding events occurred in 13% and were more frequent among women and those on long-term antithrombotic therapy.

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JAMA | Original Investigation: "Worldwide Radiation Dose in Coronary Artery Disease Diagnostic Imaging." Figure 3 shows median radiation effective doses by country by modality for SPECT, PET, CCTA, and CAC, with color-coded maps and scales.

From @jama.com: Among adults undergoing cardiac imaging for #CoronaryArteryDisease, radiation dose varied widely and was higher for CCTA in low-income countries. The findings suggest a need for standardized protocols to reduce exposure.

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Diagram titled "Figure 1. Intravascular Volume Overload," showing the pathophysiology of intravascular volume overload. It includes illustrations of decreased cardiac output, arterial underfilling, baroreceptor activation, jugular vein distension, pulmonary edema, and inferior vena cava distension.

From @jama.com:

📊 This Rational Clinical Examination evaluates the diagnostic accuracy of clinical examination, radiographic imaging, and laboratory testing in assessing volume overload in nonintubated patients.

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Figure 2 shows distributions of biomarkers at week 29. Six box plots compare biomarker levels (hs-cTnl, Non-HDL, NT-proBNP, PIGF, sFlt-1, sFlt-1/PlGF) between 'No CVD' and 'CVD' follow-up groups, with values on a log scale.

In a population-based cohort, third-trimester levels of soluble fms-like tyrosine kinase-1 (sFlt-1) and high-sensitivity cardiac troponin I were independently associated with greater long-term #CardiovascularDisease risk in pregnant women.

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Four graphs show cumulative incidence curves for major cardiovascular events (A), coronary heart disease (B), ischemic stroke (C), and cardiovascular death (D) over time, stratified by Lp(a) levels: <10, 10 to <30, 30 to <60, 60 to <90, 90 to <120, and >=120.

Very high lipoprotein(a) levels are associated with increased 30-year risk of major #cardiovascular events, coronary heart disease, ischemic #stroke, and cardiovascular death among healthy women.

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JAMA Cardiology infographic about Coronary Plaque Progression After Androgen Deprivation Therapy in Men With Prostate Cancer. Population: 65 men. Intervention: 65 patients randomized to 34 Leuprolide and 31 Relugolix. Findings: leuprolide had greater increase.

Among men with localized #ProstateCancer, treatment with GnRH agonist leuprolide resulted in greater 12-month coronary plaque progression vs GnRH antagonist relugolix, driven by increased noncalcified plaque volume.

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JAMA Cardiology editorial on Women's Health features "Assessment for Long-Term Cardiovascular Disease Risk in Pregnancy" by Sadiya S. Khan, Lynn M. Yee. Published online February 18, 2026, doi: 10.1001/jamacardio.2025.5602

💬 Editorial: Adverse pregnancy outcomes, especially hypertensive disorders, are linked to higher risk of premature #CardiovascularDisease. Pregnancy presents a key window for CV risk assessment and counseling.

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Figure 2 shows the distributions of biomarkers at week 29: A) hs-cTnl, B) Non-HDL, C) NT-proBNP, D) PIGF, E) sFlt-1, and F) sFlt-1/PIGF. Each plot compares 'No CVD' to 'CVD' follow-up data using box plots with a log scale.

In a population-based cohort, third-trimester levels of soluble fms-like tyrosine kinase-1 (sFlt-1) and high-sensitivity cardiac troponin I were independently associated with greater long-term #CardiovascularDisease risk in pregnant women.

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A "Research Letter" from JAMA Cardiology titled, "β-Blockers After Myocardial Infarction in Patients With Preserved Ejection Fraction A Meta-Analysis," by Linjie Li, MD@1, Jingge Li, MD@1, Shichen Jiang, MD@1; et al. Published online January 7, 2026.

Meta-analysis of four randomized trials found β-blockers did not reduce mortality, recurrent #MyocardialInfarction (MI), heart failure, or revascularization in patients with preserved left ventricular ejection fraction after MI. ja.ma/4act2FU

Infographic titled "JAMA Cardiology, RCT: Coronary Plaque Progression After Androgen Deprivation Therapy in Men With Prostate Cancer" shows study details: 65 men, leuprolide vs. relugolix. Leuprolide had a greater 12-mo increase in coronary artery TPV.

Among men with localized #ProstateCancer, treatment with GnRH agonist leuprolide resulted in greater 12-month coronary plaque progression vs GnRH antagonist relugolix, driven by increased noncalcified plaque volume.

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Two images, 'A' and 'B', show a left main coronary artery's origin and a course between the aorta and pulmonary artery. Image A displays 'RSP,' 'RCS,' 'LCS,' 'RA,' and 'LP.' Image B includes 'PA' and 'AO.'

A previously healthy female teenager presents with chest tightness and syncope after exertion. Electrocardiogram results showed ST-segment elevation in leads V1 through V4, aVL, and aVR troponin T levels.

What would you do next? ja.ma/3ZN12Ue

💬 Editorial: Adverse pregnancy outcomes, especially hypertensive disorders, are linked to higher risk of premature #CardiovascularDisease. Pregnancy presents a key window for CV risk assessment and counseling. ja.ma/4kIcJWe

Figure 2 shows distributions of biomarkers at week 29. Six boxplots compare "No CVD" vs. "CVD" follow-up for: A) hs-cTnl, B) Non-HDL, C) NT-proBNP, D) PIGF, E) sFlt-1, and F) sFlt-1/PlGF. Y-axes vary, all on log scales.

In a population-based cohort, third-trimester levels of soluble fms-like tyrosine kinase-1 (sFlt-1) and high-sensitivity cardiac troponin I were independently associated with greater long-term #CardiovascularDisease risk in pregnant women.

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Cardiac Magnetic Resonance (CMR) Imaging showing Left Ventricular (LV) Size and Mitral Regurgitation (MR) Severity; graphs showing LVEDV: 142 mL/m², LVESV: 60 mL/m², LV SV: 115 mL, RV SV: 75 mL, Regurgitant volume: 40 mL, Forward volume = 71 mL etc.

This narrative review describes current guidelines for intervention in severe primary #MitralRegurgitation and explores an approach that incorporates additional injury assessment, novel imaging markers, and biomarkers to optimize surgical timing.

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The image shows 3 graphs depicting change in Low-Density Lipoprotein Cholesterol (LDL-C) Level From Baseline. Graph A shows a mean of -59.09%. Graph B displays percent change from baseline. Graph C shows absolute change from baseline in LDL-C.

Monthly subcutaneous SHR-1918, a fully human monoclonal antibody targeting ANGPTL3, was associated with reduced LDL-C in adults with homozygous familial #hypercholesterolemia on stable lipid-lowering therapy.

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Density plots show proportion of patients with myocardial injury before and after transition to high-sensitivity cardiac troponin T. Plots for female/male cardiac troponin I/T. Injury defined at 16@0/34@0/9@0/16@0 ng/L, respectively.

Changing from high-sensitivity cardiac troponin I to T assay doubled myocardial injury detection and admissions, without improving 1-year cardiovascular outcomes in suspected #AcuteCoronarySyndrome.

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JAMA Cardiology study: Ticagrelor vs Prasugrel in patients with diabetes and multivessel coronary artery disease. Population: 1296 men, 504 women. Intervention: 1800 participants. Findings: Ticagrelor did not demonstrate noninferiority to prasugrel.

Among patients with diabetes and multivessel coronary artery disease, ticagrelor was not noninferior to prasugrel for reducing death, myocardial infarction, stroke, or major bleeding at 1 year after percutaneous coronary intervention.

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The image contains four graphs showing cumulative incidence vs. time in years (0-30) for major cardiovascular events, coronary heart disease, ischemic stroke and cardiovascular death, stratified by Lp(a) levels (<10 to >=120 mg/dL). Each graph includes number at risk table.

Very high lipoprotein(a) levels are associated with increased 30-year risk of major #cardiovascular events, coronary heart disease, ischemic #stroke, and cardiovascular death among healthy women.

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Figure 2. Graph shows event rates based on plaque metrics. Line graph displays 'Patients with event, %' over 'Time since randomization, mo' for TPV<87.2 mm² & TPV≥87.2 mm². Bar graph compares 'Event rate, %' for the same groups.

In symptomatic patients without known coronary disease, #CCTA-derived plaque burden and volume independently predicted MACE beyond clinical risk and standard imaging findings.

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JAMA research letter published on February 9, 2026, titled 'Impact of a Smartwatch Hypertension Notification Feature for Population Screening'. It shows that for individuals with hypertension, 41 of 100 received an appropriate alert.

From @jama.com: The FDA recently cleared a new smartwatch #hypertension notification feature for the Apple Watch. In this study, researchers applied performance metrics to nationally representative US survey data to better understand the potential population impact.

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