Nature Cardiovascular Research

Image: Jun Chen Laboratory, University of California, Los Angeles. Cover design: Bethany Vukomanovic Magnetoelastic stent for restenosis diagnosis Chen et al. describe a smart stent that combines mechanical support with continuous blood-flow sensing and demonstrate its functionality in vivo for restenosis diagnosis.

❤️Our February issue is out❤️Read about self-powered stent for real-time monitoring, cardiomyocyte regeneration through glucocorticoid receptor antagonism, immunometabolic targeting for type 2 diabetic cardiomyopathy, and more.

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A reduced TBX5-dependent gene regulatory network links atrial fibrillation and heart failure - Nature Cardiovascular Research Lazarevic et al. reveal a shared loss of a TBX5-dependent atrial gene network in cardiomyocytes and a disease-specific network gain in activated fibroblasts across atrial fibrillation and heart failur...

Research | Lazarevic et al. reveal a shared loss of a TBX5-dependent atrial gene network in cardiomyocytes and a disease-specific network gain in activated fibroblasts across atrial fibrillation and heart failure models.

www.nature.com/articles/s44...

Self-powered in-stent restenosis diagnosis via magnetoelastic stents - Nature Cardiovascular Research Chen et al. developed a self-powered smart magnetoelastic stent for real-time hemodynamic monitoring and stenosis detection.

Research|Chen et al. developed a self-powered smart magnetoelastic stent for real-time hemodynamic monitoring and stenosis detection.

www.nature.com/articles/s44...

Harnessing glucocorticoid receptor antagonism to enhance the efficacy of cardiac regenerative growth factors and cytokines - Nature Cardiovascular Research Da Pra, Boriati and colleagues show that physiological glucocorticoids suppress growth-factor-induced cardiomyocyte regeneration by inhibiting ERK signaling and propose glucocorticoid receptor antagon...

Research | Da Pra et al. show physiological glucocorticoids suppress growth-factor-induced cardiomyocyte regeneration by inhibiting ERK signaling and propose glucocorticoid receptor antagonism as a strategy to enhance their regenerative effects.

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Image: Martin Dominguez, Drexel University, Irfan Kathiriya, University of California, San Francisco. Cover design: Bethany Vukomanovic TBX5 sets boundaries for a healthy heart Kathiriya et al. identify a Tbx5 + /Mef2cAHF + cardiac progenitor lineage that demarcates the interventricular septum during development, and changes in this lineage contribute to congenital heart defects in mice. (see Kathiriya et al.)

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❤️Our January issue is out❤️Read about pathogenic mechanism of mutated ribosomal protein PRL3L, identification of cardiac progenitor lineage linked to congenital heart disease, multimodal vision graph for drug repurposing, and more.

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A disrupted compartment boundary underlies abnormal cardiac patterning and congenital heart defects - Nature Cardiovascular Research Kathiriya et al. identify a cardiac progenitor lineage with expression of Tbx5 and anterior heart field-specific expression of Mef2c that bisects the intraventricular septum during development and sho...

Research | Kathiriya et al identify a cardiac Tbx5+/Mef2cAHF+progenitor lineage that bisects the intraventricular septum during the development and show that alterations in this lineage lead to congenital heart disease.

www.nature.com/articles/s44...

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Big thanks to the Science Ministry of Serbia and our speakers, Drs. Knoblich, Guilliatt, Stewart, & Turco, and Profs. Radisic, Hedtrich, Clevers, Vunjak-Novakovic, Trayanova, Lütolf, Heilshorn, Dvir, Cho & Singh for the great event!

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Image: Bethany Vukomanovic. Cover design: Bethany Vukomanovic Genetic insights into long COVID Human genetic analyses show that thromboembolism-related variants are associated with an increased risk of long COVID, suggesting shared pathogenic pathways and implicating the thrombin receptor PAR-1 as a potential contributor. (see Schuermans et al.)

❤️Our December issue is out❤️Read about a method to measure mitochondrial membrane potential in intact hearts, gene therapy for myocardial infarction, genetic association between thromboembolism and long COVID, and more.

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Research | Neo et al. map blood emergence from three hemogenic endothelial (HE) populations biased toward distinct blood fates. HE primed for stem progenitors shows elevated chromatin and RNA splicing gene expression and greater isoform diversity.

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Image: Leonardo Sacconi, Institute of Clinical Physiology. Cover design: Bethany Vukomanovic Cardiac fibrosis and arrhythmia Three-dimensional structural reconstruction of entire cleared mouse ventricles from a diseased heart acquired using mesoSPIM tomography. Myocardium is visualized by fluorescence (gray), and fibrosis is detected via scattered light (red) (see Giardini et al.).

❤️Our November issue is out❤️Read about an imaging method that combines cardiac electrophysiology with 3D structural heart reconstruction, a targeted glycophagy ATG8 therapy reversing diabetic heart disease, and more.

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Spatiotemporal dynamics of the cardioimmune niche during lesion repair - Nature Cardiovascular Research Chan et al. generate a high-resolution spatiotemporal atlas of healing hearts and reveal cellular networks of lesion repair, including macrophage–fibroblast interactions that control late-stage fibros...

Research | Chan et al. generate a high-resolution spatiotemporal atlas of healing hearts and reveal cellular networks of lesion repair, including macrophage-fibroblast interactions that control late-stage fibrosis.

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Sex differences in the association of wearable accelerometer-derived physical activity with coronary heart disease incidence and mortality - Nature Cardiovascular Research Chen, Wang, Zhong and colleagues show that females derive greater cardiovascular benefits from guideline-recommended levels of physical activity and require less activity than males to see their benef...

Research | Chen, Wang, Zhong and colleagues show that females derive greater cardiovascular benefits from guideline-recommended levels of physical activity and require less activity than males to see their beneficial effects.

doi.org/10.1038/s441...

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PRDM16 regulates smooth muscle cell identity and atherosclerotic plaque composition - Nature Cardiovascular Research Tan et al. identify PRDM16 as a key repressor of fibrotic switching in smooth muscle cells and show that its downregulation in atherosclerosis drives smooth muscle cells toward a synthetic fate, promo...

Research | Tan et al. identify PRDM16 as a key repressor of fibrotic switching in smooth muscle cells and show that its downregulation in atherosclerosis drives smooth muscle cells toward a synthetic fate, promoting fibrous plaques.

doi.org/10.1038/s441...
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A non-canonical aryl hydrocarbon receptor pathway authorizes and safeguards clinical-scale expansion of functional human endothelial cells - Nature Cardiovascular Research Lin, Geng and colleagues identify a non-canonical AHR pathway that is activated by canonical AHR inhibitors, promoting the proliferation of quiescent endothelial cells with potential applications in c...

Research | Lin, Geng et al. identify a non-canonical AHR pathway that is activated by canonical AHR inhibitors, promoting the proliferation of quiescent endothelial cells with potential applications in cell therapy.

doi.org/10.1038/s441...

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Microtubule forces drive nuclear damage in LMNA cardiomyopathy - Nature Cardiovascular Research Amiad Pavlov, Heffler, et al. demonstrate that stress transmitted to the cardiomyocyte nucleus by the microtubule cage drives LMNA-associated cardiomyopathy and may represent a promising therapeutic t...

Research | Amiad Pavlov, Heffler et al. demonstrate that stress transmitted to the cardiomyocyte nucleus by the microtubule cage drives LMNA-associated cardiomyopathy and may represent a promising therapeutic target.

doi.org/10.1038/s441...

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B cells promote atrial fibrillation via autoantibodies - Nature Cardiovascular Research Yamazoe et al. show that B cell-derived autoantibodies contribute to the development of atrial fibrillation, suggesting that targeting the humoral immune response may represent a viable therapeutic ap...

Research | Yamazoe et al. show that B-cell derived autoantibodies contribute to the development of atrial fibrillation, suggesting that targeting the humoral immune response may represent a viable therapeutic approach.

doi.org/10.1038/s441...

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Progenitor exhausted PD-1+ T cells are cellular targets of immune checkpoint inhibition in atherosclerosis - Nature Cardiovascular Research Mulholland et al. identify progenitor exhausted T cells, expressing intermediate levels of PD-1 (PD-1int), as a prominent source of pro-inflammatory cytokines in the murine atherosclerotic aorta and p...

Research | Mulholland et al. identify progenitor exhausted T cells, expressing intermediate levels of PD1, as a prominent source of pro-inflammatory cytokines in the murine atherosclerotic aorta and potential cellular targets.

doi.org/10.1038/s441...

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Image: ScienceBrush Design. Cover design: Bethany Vukomanovic; RNA editing in atherosclerosis: Weldy et al. show that expression of the RNA-editing enzyme ADAR1 in smooth muscle cells regulates activation of the double-stranded RNA sensor MDA5, in a new model of atherosclerosis.

❤️Our October issue is out❤️Read about the RNA editing enzyme ADAR1 regulating atherosclerosis progression, PGC-1α and cardiac adaptation to exercise training, the role of LYVE1-macrophages in heart regeneration and peripheral artery disease, and more.

Research | Barbera et al. identify and map genetic variants that alter the characteristics of vascular smooth muscle cells and contribute to the risk of coronary artery disease.

doi.org/10.1038/s441...

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Research | Giardini et al. present an imaging method that combines measurements of cardiac electrophysiology with high-resolution 3D structural reconstructions and detects electrical coupling between cardiomyocytes and non-myocytes in murine hearts.

doi.org/10.1038/s441...

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Research | Wünnemann et al. generate a subcellular resolution spatial map of the murine heart after myocardial infarction, revealing that immune cells can infiltrate the organ through the endocardium.

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ANTXR1 blockade enhances cardiac function in preclinical models of heart failure - Nature Cardiovascular Research Boccella, Yu and colleagues reveal that the transmembrane protein ANTXR1 regulates post-infarction fibrotic remodeling, and its inhibition blocks collagen turnover and improves heart function.

Research | Boccella, Yu and colleagues reveal that the transmembrane protein ANTXR1 regulates post-infarction fibrotic remodelling, and its inhibition blocks collagen turnover and improves heart function.

doi.org/10.1038/s441...

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Oxidative phosphorylation is required for cardiomyocyte re-differentiation and long-term fish heart regeneration - Nature Cardiovascular Research Lekkos et al. show that a metabolic switch toward oxidative phosphorylation is required for cardiomyocyte re-differentiation and heart regeneration after injury in fish.

Research | Lekkos et al. show that a metabolic switch towards oxidative phosphorylation is required for cardiomyocyte re-differentiation and heart regeneration after injury in fish.
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Targeted glycophagy ATG8 therapy reverses diabetic heart disease in mice and in human engineered cardiac tissues - Nature Cardiovascular Research Mellor et al. report that deficiency of GABARAPL1, an ATG8-specific linking protein, impairs diastolic function in diabetic mice. This effect can be reversed by gene delivery of the gene encoding GABARAPL1 in diabetic mice and a human organoid model of type 2 diabetes.

Research | Deficiency of GAPARAPL1 impairs diastolic function in diabetic mice. This effect can be reversed by gene delivery of the gene encoding GABARAPL1 in diabetic mice and in human organoids of type 2 diabetes.
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Image: Kathryn Berg. Cover design: Bethany Vukomanovic

❤️Our September issue is out❤️Discover how primary cilia regulate valve development, a human ocular outflow on-chip, regional and sex-specific transcriptional programs in the aorta and more!
www.nature.com/natcardiovas...

Our chief editor, Vesna Todorovic, and associate editor Andrea Tavosanis are attending the #ESCCongress in Madrid! Get in touch if you would like to learn more about the journal or discuss your work

Excessive HIF-1α driven by phospholipid metabolism causes septic cardiomyopathy through cytopathic hypoxia - Nature Cardiovascular Research Watanabe et al. show that cytopathic hypoxia, through upregulation of COX2 and secretory PLA2, stabilizes HIF-1α, contributing to impaired mitochondrial respiration and reduced cardiac contraction in ...

Research | Watanabe et al. show that cytopathic hypoxia, through the upregulation of COX2 and secretory PLA2, stabilises HIF-1a, contributing to impaired mitochondrial respiration and reduced cardiac contraction in septic cardiomyopathy.
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Image: Heart and uterus image: Viarshyla Hanna / Alamy Stock Photo. Cover design: Bethany Vukomanovic

❤️Our August issue is out❤️Discover how premenstrual disorders increase cardiovascular risk, a new diagnostic deep learning model for hypertrophic cardiomyopathy, the relationship between membrane cholesterol accessibility and vascular leakage, and more!
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Preventing the phosphorylation of RyR2 at canonical sites reduces Ca2+ leak and promotes arrhythmia by reactivating the INa current Nature Cardiovascular Research - Zheng et al. generated a mouse model of phospho-ablation in all canonical ryanodine receptor 2 (RyR2) phosphorylation sites. They show that RyR2 phosphorylation at...

Zheng et al. generate a triple phospho-ablation mouse model to show that RyR2 phosphorylation at canonical sites is dispensable for chronotropy and inotropy, but required for electrical stability during adrenergic stimulation.
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Tetraspanin-enriched membrane domains regulate vascular leakage by altering membrane cholesterol accessibility to balance antagonistic GTPases Nature Cardiovascular Research - By regulating the level of accessible cholesterol on endothelial cells via OSBP/ORP-mediated transport, tetraspanin tunes the balance of Cdc42 and RhoA activities...

Ding, Y., Chen, J., Liu, S. et al show that tetraspanin regulates the level of accessible cholesterol on endothelial cells via OSBP/ORP-mediated transport to balance Cdc42 and RhoA activities and influence vascular inflammation.

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