Phillip Grote

A nice opportunity to repost some great work from Mary Lyon. Transmission Ratio Distortion in Mice - www.annualreviews.org/content/jour...

If you want to explore ncRNA dynamics during mammalian development, love microscopy, and are not afaraid of transposons biology, apply‼️
We are looking for a postdoc to join our team at @imbavienna.bsky.social
More details 👇🏻

its amazing how chatgpt knows everything about subjects I know nothing about, but is wrong like 40% of the time in things im an expert on. not going to think about this any further

Mechanisms linking cytoplasmic decay of translation-defective mRNA to transcriptional adaptation Transcriptional adaptation (TA) is a genetic robustness mechanism through which mutant messenger RNA (mRNA) decay induces sequence-dependent up-regulation of so-called adapting genes. How cytoplasmica...

This is a fascinating paper that reveals defined and clear mechanism for a phenomenon that for some seemed unbelievable- the up regulation of genes paralogous to those with specific types of inactivating mutations. This is called transcriptional adaptation 1/ www.science.org/doi/10.1126/...

Attention RNA biology and antisense therapy folks: this is HUUUUUUGE!!! Termination windows as therapeutic opportunity!

Be seen at TT2026 in Leiden!
Sponsorship and exhibition opportunities are now available for TT2026.
Put your brand in front of a global audience and be part of an exciting international conference.
✨ Sponsorship Packages
✨ High-impact Brand exposure

📩 Enquire now: tt2026@in-conference.org.uk

Association of tumour-associated macrophage states with non-conserved lncrnas in lung cancer - Genes & Immunity Genes & Immunity - Association of tumour-associated macrophage states with non-conserved lncrnas in lung cancer

Our atlas of lncRNAs associated with M1 and M2-like phenotype in TAMs in lung cancer is out www.nature.com/articles/s41...

Kinoplakat des Dokumentarfilms "BLAME", der am 16. April im Kino zu sehen sein wird.

Termine der Filmgespräche mit Regisseur Christian Frei: Köln (3.2.), Düsseldorf (4.2.), Bremen (5.2.), Berlin (6.2.) und München (7.2.)

Wir sind bei der Kinotour von "BLAME" in Köln, München und Berlin mit dabei! Der erste Termin findet am 3.2. im Odeon Kino in #Köln statt. Nach der Filmvorführung spricht Regisseur Christian Frei mit Leon Wansleben. Er ist Forschungsgruppenleiter @mpifg.bsky.social 📽️ www.mpg.de/25990221/dok...

AlphaGenome is out in @nature.com today along with model weights! 🧬

📄 Paper: www.nature.com/articles/s41...

💻 Weights: github.com/google-deepm...

Getting here wasn’t a straight path. We discussed the story behind the model, paper & API in the following roundtable: youtu.be/V8lhUqKqzUc

Human heart organoids reveal a regenerative strategy for mitochondrial disease https://www.biorxiv.org/content/10.64898/2025.12.18.695153v1

CISTR-ACT was the 1st lncRNA involved in inter-chromosomal contacts and in Mendelian disease (brachydactyly). We now revealed CISTR-ACT’s molecular mechanism: tinyurl.com/CISTR-ACT, @sickkidsto.bsky.social, @uoftpress.bsky.social, @natcomms.nature.com, @natureportfolio.nature.com

A systems genetics approach to uncover mitochondrial drivers of heart failure reveals mitochondria-nuclear cross talk in genetically diverse mouse strains https://www.biorxiv.org/content/10.64898/2025.12.12.693865v1

First day of the #Microbiome Symposium at #Georg-Speyer-Haus organized by LOEWE-FCI professor Canan Arkan was a great success.
Thanks to all speakers & supporters (Cathrin Schleussner from Schleussner Stiftung and Martin Zörnig, Else-Kröner-Fresenius-Stiftung).
Looking forward to the second day!

RNA innate immunity constitutes a barrier for interspecies chimerism Interspecies PSC co-culture induces horizontal RNA transfer that activates innate immunity in “winner” mouse cells, a response that is alleviated by Mavs deletion, thereby enhancing “loser” human PSC survival and chimerism.

Now online! RNA innate immunity constitutes a barrier for interspecies chimerism

🍾🥂 @melanietichet.bsky.social of @loewe-fci.bsky.social is an awardee of the Metastasis Prize of the Beug Foundation 2️⃣0️⃣2️⃣5️⃣. We congratulate👏🏼 and look forward to the progress the research will bring to the treatment of metastatic melanoma in older patients➡️https://www.beugstiftung-metastase.de/tichet/

Happy to welcome Wael Mansour from MSNZ Hamburg / Universitätsklinikum Hamburg Eppendorf on November 25 2025; 1:30 p.m.

"From mutation to medication: Personalizing prostate cancer
treatment via targeting DNA repair pathways"

Venue: Georg-Speyer-Haus, Lecture Hall
Hosts: Anne Fassl & Henning Reis

Job advertisement

Are you looking to establish yourself as a scientific group leader? BRIC is recruiting 1-2 junior group leaders to join our research centre in the heart of Copenhagen.
See more at www.bric.ku.dk

Please repost and get in touch if you are curious.

Nuclear-import receptors remodel the dilute phase to suppress phase transitions of RNA-binding proteins with prion-like domains. RNA-binding proteins (RBPs) with prion-like domains, including FUS, hnRNPA1, and hnRNPA2, assemble into functional, metastable condensates that organize ribostasis, but can also transition into self-t...

www.biorxiv.org/content/10.1...

1 Milliarde Euro gehen der Allgemeinheit jedes Jahr durch Steueroasen verloren. Mit dem @zdfmagaz.in haben wir Gemeinden in Deutschland ausfindig gemacht, in denen Konzerne & Promis von einem extrem niedrigen Gewerbesteuerhebesatz profitieren. Klickt euch durch auf steueroasen.watch!

Regulated decay of microRNAs plays a critical role in controlling body size in mammals! Check out our new paper in @genesdev.bsky.social and see thread previously posted with our pre-print 👇 for more info. Congrats to Collette LaVigne, Jaeil Han, and all authors!
genesdev.cshlp.org/cgi/content/...

🧬Science Minister Timon Gremmels today presents the 🆕funding notification to @loewe-fci.bsky.sociall, which will continue to receive state funding in 2026+2027 – a recognition of the outstanding achievements of the LOEWE Center!💪🏼🔬➡️ www.linkedin.com/posts/goethe...

Our latest paper has just been published in Cell!

doi.org/10.1016/j.ce...

We developed a new method called MCC ultra, which allows 3D chromatin structure to be visualised with a 1 base pair pixel size.

tRNA-overlapping long non-coding RNA loci repress codon-biased genes Ahmed et al. define tRNA-overlapping lncRNAs (tROLs). tROLs in gene-dense regions interact between chromosomes and depend on each other’s transcription. tROL perturbations silence codon-biased genes i...

📢 Paper Alert: tinyurl.com/yzy2d864. We characterized tRNA-overlapping lncRNA loci = tROLs! tROL perturbations silence
codon-biased genes in inter-chromosomal proximity. tROLs bridge the non-coding
and coding genomes. @sickkidsto.bsky.social @uoftpress.bsky.social

Two group leader positions available in the broader areas of RNA science, RNA technologies, and RNA medicine. Attractive packages and a great environment. Come and join us at Helmholtz RNA Würzburg, Bavaria.

This is figure 5, which shows processability and formability of BM-plastics for diverse products.

A paper in Nature Communication reports on a new method to produce strong, biodegradable plastic from bamboo. The bioplastic resembles oil-based plastics in strength, shapeability, and thermal stability but can biodegrade in soil within 50 days. go.nature.com/4h1xv0X 🧪

#RNAsky

A screenshot of a post by the Jane Goodall Institute on LinkedIn stating that they learned that Dr. Goodall passed away due to natural causes in California while on her speaking to her current speaking tour there.

The world has lost its most powerful advocate for nature and hope. Yet many remain who will continue her legacy and I know she will continue to inspire generations more.

Excited to share our first preprint! We developed an image-based pooled screen to uncover regulators of HP1 condensates and discovered a link with intronic RNA and RNA processing. 👏 Congrats to all authors, especially Matthew, Shaopu & Chris!

🚀 Our new paper is out @natmethods.nature.com!

Kuffer & Marzilli engineered conditionally stable MS2 & PP7 coat proteins (dMCP & dPCP) that degrade unless bound to RNA, enabling ultra–low-background, single-mRNA imaging in live cells.

🔗 www.nature.com/articles/s41...
🧬 www.addgene.org/John_Ngo/

Only single cell sequencing of the all these post docs will reveal why