Additionally, Tsirkas et al. show that R-loops, under specific conditions, can be beneficial for cells, by reducing excessive RNAPII load on highly-transcribing genes, thus preventing potential TRCs.
We are very happy to see this project led by @ioannistsirkas.bsky.social reach the final stages! 🥳
Our latest research is online in the @biorxivpreprint.bsky.social! 🧬🎉
🔎 We have developed a novel, single-cell real-time approach to monitor R-loop generated TRCs, and we have shown R-loop-mediated, replisome-controlled transcription repression.
www.biorxiv.org/cgi/content/...
Such a nice review for one of our latest research works!
Wishing you all the best as you move on to your next adventure, we are so proud of you! It’s been great having you in the lab — we’ll miss you!
Two days of science, international cooking, and breathtaking hikes in the Bavarian Alps—our lab retreat in Mittenwald had it all! Great discussions, great food, and even better company.
🚨Paper Alert!
👏 Big congrats to @marcelwerner.bsky.social, ManuelTrauner & rest of @hamperllab.bsky.social team for this brilliant work!
🧬 Check out their amazing research diving into how #TRCs and DOT1L impact genome stability.
A must-read 🧵 for #transcription, #replication & #epigenetics fans👇!
Thank you, Umberto!
Happy to hear it, thank you Marcelo!
Thank you, Daphne!
How can we improve gene regulatory network inference from noisy scRNA-seq data? Our new review in @molsystbiol.org explores the latest methods integrating prior knowledge to enhance reliability. Plus, some suggestions on how to improve benchmarking!
www.embopress.org/doi/full/10....
Proud to share our latest publication in @narjournal.bsky.social! A fantastic team effort led by @marcelwerner.bsky.social and Manuel T., where we explore the chromatin dynamics at transcription-replication conflicts (TRC) sites and their impact on genome stability using a novel TRC reporter system.
Best first bsky post posible 4us:
2025 INTERNSHIP CALL IS NOW OPEN!
Ready for an adventure this summer?
Join our 2025 #Epigenetics #SummerInternship at Helmholtz Munich! Dive into AI, stem cells, nutrition and cutting-edge research, while gaining hands-on experience.
Apply now! 👉 bit.ly/40g1BWL
