Worboys Lab

Nano-org, a functional resource for single-molecule localisation microscopy data - Nature Communications An open-access resource, nano-org, enables researchers to explore and compare the nanoscale 2 organisation of proteins imaged using single-molecule localisation microscopy, advancing insights 3 into cell biology, disease, and drug response.

It was fantastic to contribute to the latest research from @owenlabuob.bsky.social now out at @natcomms.nature.com. This is a great initiative and could be an important resource for the SMLM community.
www.nature.com/articles/s41...

We have a new Postdoc position advertised as part of our recent long-term Wellcome funding to join an established Postdoc and technician. I’m so excited to explore the role of the glycocalyx in CNS-inflammation. So many tools and expertise to work with! www.jobs.manchester.ac.uk/Job/JobDetai...

Our new paper is out! Khodor Hazime led the brilliant work at the @dandavis101.bsky.social lab that shows *how* engagers that bring NK cell receptors together at the immune synapse boost activation against tumour cells

www.pnas.org/doi/10.1073/...

🧩 Antigen presentation is complex - but imaging is bringing clarity.

@doreenlau.bsky.social‬ & @timmunologist.bsky.social‬ review how advanced imaging illuminates T-cell–APC interactions, peptide-MHC dynamics, and more in cancer immunity.

📖 https://bit.ly/3TkIasN

#CancerImmunology

Research Associate in Synthetic Chemistry and Chemical Biology:Oxford Road

Delighted to advertise a collaborative postdoc position available in the lab to develop new proximity labelling tools, funded by a BBSRC Transformative Research Technology grant:

www.jobs.manchester.ac.uk/Job/JobDetai...
#ChemicalBiology #SyntheticChemistry

Click biology highlights the opportunities from reliable biological reactions Nature Chemical Biology - This Perspective discusses click biology as an analogy to click chemistry and examines reactions carried out using building blocks present in every living cell, enabling...

Brilliant overview of ‘Click Biology’

rdcu.be/etLqI

Research Associate in Mucosal Immunology :Manchester

🚨 The Menon lab is hiring a postdoc!

Interested in mucosal immunology? Come join our team to study lung-infiltrating B cell dynamics in COPD & other chronic lung diseases
@ukri.org @lydiabeckeriii.bsky.social

Please help spread the word #ImmunoSky

www.jobs.manchester.ac.uk/Job/JobDetai...

Delighted to have visited the Dept. of Pathology at the University of Cambridge today to present our work. Some fantastic discussions!

TIGIT deficiency promotes autoreactive CD4+ T-cell responses through a metabolic‒epigenetic mechanism in autoimmune myositis - Nature Communications Aberrant activation of autoreactive T cells is a hallmark of autoimmune diseases. Here, by analysing CD4 T cells from patients with polymyositis and mice with experimental autoimmune myositis, the aut...

More evidence that TIGIT is an important player in autoimmunity and independent of its effect on CD226

www.nature.com/articles/s41...

#immunosky

The subfornical organ is a nucleus for gut-derived T cells that regulate behavior @nature.com
www.nature.com/articles/s41...
www.nature.com/articles/d41...

The deadline for this PhD is fast approaching. We are looking for a promising synthetic chemist to make new chemical biology tools to learn more about nucleic acid interactions. This is a collaborative project with the Trowbridge Lab in @uomscieng.bsky.social. If interested, get in touch soon!

Inhibitory TIGIT signalling is dependent on T cell receptor activation TIGIT is an immune checkpoint receptor that can signal via cytoplasmic ITT-like and ITIM motifs to regulate T cell function. The signalling molecules that mediate inhibitory TIGIT signalling in T cell...

Our latest research is now available as a pre-print at BioRxiv. We show that the immune checkpoint receptor TIGIT cannot signal in T cells without simultaneous TCR stimulation.

#ImmunoSky

www.biorxiv.org/content/10.1...

Journal of Cell Science Meeting 2026 Imaging Cell Dynamics Date: 11 – 14 May 2026 Venue: Montanyà Hotel, Catalonia, Spain Register your interest

After the success of our 2023 Imaging Cell Dynamics conference, we’ll be hosting a second #JCSImaging meeting in 2026, organised by @franbottanelli.bsky.social, @guijacquemet.bsky.social‬, @drmichaelway.bsky.social‬ & Giulia Zanetti.
To register your interest: www.biologists.com/meetings/jcs...

(EPSRC DTP) Super-resolution proximity nucleotide labelling at The University of Manchester on FindAPhD.com PhD Project - (EPSRC DTP) Super-resolution proximity nucleotide labelling at The University of Manchester, listed on FindAPhD.com

We have a PhD available in the lab to design new chemical tools to do super resolution proximity labelling of nucleotides. Come join us!!

#ChemSky #ChemBio

www.findaphd.com/phds/project...

Hi everyone 👋 I’ve been nominated for the role of ECR representative position on the Member Representative Forum at @britsocimm.bsky.social. If you’d like to see me in this position and want to vote for me, you can follow this link: www.immunology.org/news/bsi-com... #immunosky

Inhibitory TIGIT signalling is dependent on T cell receptor activation TIGIT is an immune checkpoint receptor that can signal via cytoplasmic ITT-like and ITIM motifs to regulate T cell function. The signalling molecules that mediate inhibitory TIGIT signalling in T cell...

Our latest research is now available as a pre-print at BioRxiv. We show that the immune checkpoint receptor TIGIT cannot signal in T cells without simultaneous TCR stimulation.

#ImmunoSky

www.biorxiv.org/content/10.1...

Research Associate in Imaging Human Immunology:Oxford Road

Our lab has a postdoc position available to use super-resolution microscopy to understand how nanoscopic localisation of immune checkpoints dictates their function.

Please get in touch if interested in applying.

www.jobs.manchester.ac.uk/Job/JobDetai...

#ImmunoSky #Imaging #Microscopy

Wow

Research Associate in Breast Cancer Metastasis:CRUK Oglesby Cancer Research Building, 555 Wilmslow Road, M20 4GJ

New postdoc position in @frances-turrell.bsky.social lab. Great opportunity to join a new group, doing exciting work 🧪

Get in touch if you want to chat about life in the lab (it's fab)!

www.jobs.manchester.ac.uk/Job/JobDetai...

#ImmunoSky

Wellcome Connecting Science CRISPR Screening and Analysis Course dates: 21-26 September 2025 Location: Wellcome Genome Campus, UK Application and bursary deadline: 3 June Apply now

Explore #CRISPR screening in our two-part course! #CRISPRAnalysis25

Blends online learning with in-person training, to help you master the methods and applications of CRISPR screening and analysis.🧬

Focusing on:

▶️ #Oncology
▶️ #Neurodegeneration
▶️ #Immunology

Apply by 3 June
📎Info: bit.ly/4iBpEah

Research Associate in Imaging Human Immunology:Oxford Road

Our lab has a postdoc position available to use super-resolution microscopy to understand how nanoscopic localisation of immune checkpoints dictates their function.

Please get in touch if interested in applying.

www.jobs.manchester.ac.uk/Job/JobDetai...

#ImmunoSky #Imaging #Microscopy

Frontiers | CD8α and CD70 mark human natural killer cell populations which differ in cytotoxicity

A recent study we were involved in is now online showing distinct populations of NK cells with different killing potential:

www.frontiersin.org/journals/imm...

🚨Thanks to generous support from @cancerresearchuk.org, we have multiple postdoctoral positions available in our lab (www.mardakhehlab.info) @oxfordbiochemistry.bsky.social to study ribosomes synthesis in cancer. Get in touch if you’re interested + RT and spread the word! 📣 #cancer #RNA 🚨

Trogocytosis of chimeric antigen receptors between T cells is regulated by their transmembrane domains Chimeric antigen receptor trogocytosis transfers antitumor immunity between T cells and is dictated by their transmembrane domain.

If you're a T cell enthusiast, check out our latest findings published recently in #Science Magazine | #Immunology.

Uncovering the mechanism of CAR trogocytosis between T cells has been extremely fun.

www.science.org/doi/10.1126/...

NLRP3-mediated glutaminolysis controls microglial phagocytosis to promote Alzheimer’s disease progression How NLRP3 impacts Alzheimer’s disease (AD) is unclear. McManus et al. find that NLRP3 is located at mitochondria where it regulates microglial metabolism. Depletion or chronic pharmacological inhibiti...

I am thrilled to share our latest article that has been published in @cp-immunity.bsky.social. We describe a new role for NLRP3 outside of its #inflammasome complex, where it can regulate microglial #metabolism & key metabolites that affect the epigenetic landscape(1)
www.cell.com/immunity/ful...

Scratching promotes allergic inflammation and host defense via neurogenic mast cell activation Itch is a dominant symptom in dermatitis, and scratching promotes cutaneous inflammation, thereby worsening disease. However, the mechanisms through which scratching exacerbates inflammation and wheth...

🦠🤲 Scratching: Friend or Foe?

A new study found that scratching worsens allergic inflammation but also helps fight infections by activating neuroimmune pathways.

The itch-scratch cycle has a complex role in health.

🔗 www.science.org/doi/10.1126/...

#Immunology #Neuroscience #SciComm 🧪

If anyone fancies giving it a go we can run a workshop at the Strathclyde Optical Microscopy Course 2025. More details at www.centreforbiophotonics.com/somc25, deadline for applications is 17th January 2025. More details at bsky.app/profile/liam...

Decoding the molecular interplay of CD20 and therapeutic antibodies with fast volumetric nanoscopy Elucidating the interaction between membrane proteins and antibodies requires whole-cell imaging at high spatiotemporal resolution. Lattice light-sheet (LLS) microscopy offers fast volumetric imaging ...

Super happy to see the manuscript of my former PhD student and close friend Arindam Ghosh, @arindam92.bsky.social, and the Markus Sauer lab, @sauer-lab.bsky.social, being pblished in Science: www.science.org/doi/10.1126/...

Thrilled to share our @sciimmunology.bsky.social paper! We report that rodent PD-1 is weaker than human PD-1 (reduced ligand binding & signaling) & lacks a conserved vertebrate motif. Humanizing mouse PD-1 disrupts T cell anti-tumor responses, raising many questions. science.org/doi/10.1126/...

Coupling antigens from multiple subtypes of influenza can broaden antibody and T cell responses The seasonal influenza vaccine contains strains of viruses from distinct subtypes that are grown independently and then combined. However, most individuals exhibit a more robust response to one of the...

Cool new work from Mark Davis, @wanglaboratory.bsky.social and coworkers @stanfordmedicine.bsky.social

www.science.org/doi/10.1126/...