KCNQ Lab

Multivalent Interactions between Chaperone and Ribosome-Nascent Chain Complex Revealed by High-Speed AFM and MD Simulations Trigger Factor (TF) is a primary ATP-independent molecular chaperone in bacteria that engages nascent polypeptide chains emerging from the ribosomal exit tunnel to assist their folding. However, the r...

Our new work is out!
HS-AFM × MD -->> new insights into multivalent TF–ribosome interactions.
pubs.acs.org/doi/10.1021/...

Real-time Visualization of Trigger Factor on Translating Ribosomes https://www.biorxiv.org/content/10.1101/2025.05.16.654432v1

Sara M. Alicante presenting her results on Kv7.4 voltage sensor activation during channel gating and how redox regulation affects its behavior at the Biophysical Society Meeting in Los Angeles #BPS2025 #Biophysics #Kv7 #Redox #IonChannels

KCNQ lab has arrived in Los Angeles for the @BiophysicalSociety Meeting! Excited to share our work and engage with the amazing scientific community. See you in the sessions! #BPS2025 #Biophysics

Celebrating a year full of science and achievements within the KCNQ group 🥳 A relaxed dinner to share laughs, lab stories, and, of course, a toast to more discoveries together! 🍷🔬🤯 #TeamKCNQ

Surfing M-current in Costa da Caparica

Such an engaging presentation by Álvaro Villarroel on redox modulation of Kv7 channels at #IC3TC! Shedding light on their role in neuroprotection. Exciting results on the horizon—stay tuned!👀

Calmodulin acts as a chaperone during co-translational folding of the Kv7.2 channel Calcium Responsive Domain In vivo , the majority of nascent protein chains must begin folding during translation in order to obtain their native structure. While the importance of co-translational folding has become increasing...

www.biorxiv.org/content/10.1...
Take a look at our latest preprint! 👀
#CaM #chaperone #co-translationalfolding

We're visiting Lisboa #IC3TC #CaparicaChristmasConference

Presenting our findings at the Caparica Christmas Conference #IC3TC

KCNQ-Lab enjoying a day in Sintra