Exited to share Current Opinion review on how chromatin hubs involving multiple enhancers and promoters are formed, and their potential roles in gene regulation: www.sciencedirect.com/science/arti...
Congrats! π
How could a simple self-replicating system emerge at the origins of life? RNA polymerase ribozymes can replicate RNA, but existing ones are so large that their self-replication seems impossible. Could they be smaller?
Excited to share our latest work in @science.org on a new small polymerase.
1/n
πOur new LMB website is live!π
Fresh design, better navigation, same first-class science.
Take a look around β‘οΈ mrclmb.ac.uk
Spinnerets are a defining feature of many arachnid species - this paper tells a really cool story about their gain and loss throughout evolution π·οΈπΈοΈ
www.science.org/doi/10.1126/...
π§¬π¬@science.org A genetically encoded device for #transcriptome storage in mammalian cells | Science www.science.org/doi/10.1126/... @broadinstitute.org
LMB Seminar Paul Nurse Francis Crick Institute CDKs and Cell Cycle Control Monday 26 January at 11 am Max Perutz Lecture Theatre and Zoom.
Join Paul Nurse from the Francis Crick Institute at the LMB on Monday 26th January at 11am (GMT) for a #LMBSeminar on βNew Perspectives on CDKs and Cell Cycle Controlβ
Visit our website for more details: www2.mrc-lmb.cam.ac.uk/news-and-eve...
This is so cool!! One of the best examples Iβve seen of enhancer selection.
a,b Average sleep time during 36βh under LD in C. andromeda (a) and N. vectensis (b). White, black, and red horizontal bars represent light, dark, and SD periods, respectively (C. andromeda: ZT17-23, N. vectensis: ZT20-ZT4). c, d Sleep time accumulation of the previous 12βh (sliding average) in C. andromeda (c) and N. vectensis (d) during 36βh under LD. Black arrowheads indicate sampling time for the DNA damage assay presented in (iβl). e Confocal z-projection of a C. andromeda rhopalium and adjacent peri-rhopalial tissue. White squares mark representative single nucleus in the mesoglea. Red asterisk indicates rhopalium. Scale bar 150βΞΌm. f Confocal z-projection showing the mOrange-positive endodermal nervous system in tg(-2.4NvElav1b:mOrangeCAAX) N. vectensis. White squares mark representative single neurons. Scale bar 100βΞΌm. g Representative images of cells in the peri-rhopalial tissue of C. andromeda sampled at ZT11, ZT23, and the following day (Day2 ZT11). Nucleus stained by DAPI (gray), and Ξ³H2AX foci (magenta) are stained using immunohistochemistry. Scale bar 4βΞΌm. h Representative images of Ξ³H2AX staining (magenta) in mOrange-positive neurons (green) of tg(-2.4NvElav1b:mOrangeCAAX) N. vectensis sampled at ZT17, ZT8, and the following night (Night2 ZT17). Nucleus stained by DAPI (gray). Scale bar 2βΞΌm. i, k Normalized number of Ξ³H2AX foci per nucleus of control and sleep-deprived C. andromeda under LD. i Control: Day1 (nβ=β24, 1.00βΒ±β0.64), Night (nβ=β22, 0.55βΒ±β0.55), Day2 (nβ=β26, 1.31βΒ±β0.63). k Sleep-deprived: Day1 (nβ=β27, 1.00βΒ±β1.09), Night (nβ=β31, 2.11βΒ±β1.13), Day2 (nβ=β28, 1.42βΒ±β1.12). Values are mean Β± s.d. (n=rhopalia from 8-10 animals per time point).
Jellyfish sleep, which is already bizarre given they have no brains. DNA damage accumulates in their neurons when jellyfish are awake, and it gets repaired when they sleep. This might be something fundamental, evolutionarily, to the role of sleep. π§ͺπ
Link: nature.com/articles/s41...
Our preprint "Predictive design of tissue-specific mammalian enhancers that function in vivo in the mouse embryo" is on bioRxiv: www.biorxiv.org/content/10.6... . Amazing collaboration by @shenzhichen1999.bsky.social, Vincent Loubiere (@impvienna.bsky.social,@viennabiocenter.bsky.social),... (1/2)
Out today officially! Such a cool story and I feel very lucky to have been involved - congrats to @sumrubayin.bsky.social and @jensbager.bsky.social along with everyone else involved! Was fun to get back to my roots in cerebellar development for a bit π§
journals.biologists.com/dev/article/...
So happy to see this amazing work by @annamalkowska.bsky.social out! A huge effort that ended in a really exciting story - read if you are interested in epigenetic maintenance of cell states and if you aren't, read it anyway! πͺ°π§ π§¬
www.sciencedirect.com/science/arti...
βA process which led from the amoeba to man appeared to the philosophers to be obviously a progress - though whether the amoeba would agree with this opinion is not known"
- Bertrand Russell, 1976.
Time-lapse video of Vampyrella lateritia eating Spirogyra algae from Science Source/Oliver Skibbe. π¦
Our scientists have been busy this year!
From dinosaurs to diatoms, they have helped to describe an amazing 262 new species from all around the world! πͺΈπ π¦π¦πͺ±
Read more about this yearβs new species list ππ»
www.nhm.ac.uk/discover/new...
BBC News - Top UK scientist says research visa restrictions endanger economy
www.bbc.com/news/article...
Cool work on how male pregnancy works in seahorses and other Syngnathids - brood pouch formation is androgen responsive. Interesting comparison of cell types to mammalian parallels at the end too!
www.nature.com/articles/s41...
I havenβt enjoyed reading a review so much as this in a long time - an in depth and beautifully composed overview of metazoan evolution through the lens of transcription factors and transcriptional regulation π§¬
www.nature.com/articles/s41...
Tiny pink and cream colored cube under 2mm stuck to the surface of a leaf. There were several, scattered around randomly, but the photo is cropped to show the one that was in best focus. The second picture shows a bit of my thumbnail in the corner, with sparkly nail polish.
Tiny pink and cream colored cube under 2mm stuck to the surface of a leaf. There were several, scattered around randomly, but the photo is cropped to show the one that was in best focus. The second picture shows a bit of my thumbnail in the corner, with sparkly nail polish.
Diminutive fairy wombat poop. Tiny cubes under 2mm on each side.
These are egg sacs made by a spider in the family Theridiosomatidae.
They made yesterdayβs hike special. Finding something Iβve never seen before is such a thrill.
π± #nature #macro #spider
Really great to see more studies like this, exploring how tiny changes in enhancer sequences over evolution can have tangible effects on developmental processes! journals.biologists.com/dev/article/...
Domesticated animals have pulled our heavy carts and turned our large mills for centuries. But what about the opposite end of the spectrumβwhat if the wheel you want to turn is so small you canβt see it?
Turns out we can harness the power of bacteria to power the worldβs smallest machines.
1/7 βοΈπ§ͺ
What is a promoter? And how does it work?
We very happy to share our latest work trying to understand enhancer-promoter compatibility.
I am very excited about the results of @blanka-majchrzycka.bsky.social, which changed the way I think about promoters
www.biorxiv.org/content/10.1...
I am thrilled to share our latest story led by the incredibly talented Brooke DβArcy and Camila Musso. We discover a rich world of local gene expression in radial glia, essential neural and glial precursors, and develop a new method for sub-cellular mRNA manipulation. www.biorxiv.org/content/10.1...
Delighted that Ziqi Dong's PhD paper is out for all to read! Hypoxia is fundamental to normal development, and fascinating! Thanks to all of our co-authors including @jamesnathanlab.bsky.social @jellevda.bsky.social authors.elsevier.com/sd/article/S...
Congrats!! Itβs such cool work, happy to see it out πΎ
New online: Computational design of sequence-specific DNA-binding proteins
Very cool paper providing mechanism to how sea slugs can retain photosynthetically active chloroplasts (also love the term kleptosomes) - www.cell.com/cell/fulltex...
Congratulations!! π
A map of flight paths emanating from breeding colony of gulls, with this caption: Early on, LifeWatch noticed something odd. Most gulls were making daily trips to Mouscron, a city on the French border 65 km away. They went to investigate and found the birds bingeing on discarded snacks at the Roger & Roger potato factory.
Today in relatable science: Gulls making a mysterious daily trip that turned out to be to a potato chip factory
My Cyclops (type of freshwater copepod) culture is teeming with life π§«
