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A genetically encoded device for transcriptome storage in mammalian cells Understanding how cells make decisions over time requires the ability to link past molecular states to future phenotypic outcomes. We present TimeVault, a genetically encoded system that records and s...

Ok this is next level insane! Molecular recording with minimal impact on transcript abundance and gene function!

www.science.org/doi/epdf/10....

...the Macro category left me feeling attacked...😅

2025 Australian Geographic Nature Photographer of the Year See nature in a whole new light in this stunning, photographic exhibition, featuring works by some of the world's best nature photographers.

If in Sydney don't miss the #free 2025 Australian Geographic Nature Photographer of the Year exhibit at the Australian Museum! The photos are breathtaking & Ross Gudgeon’s Fractal Forest inside-out macro of a soft cauliflower coral was mind blowing! Though...

@ausgeo.newsmast.social.ap.brid.gy

Yes but play it backwards.

Congrats Kelly and everyone involved! Lovely work really enjoyed reading it.

Point of no returns: researchers are crossing a threshold in the fight for funding With so little money to go round, the costs of competing for grants can exceed what the grants are worth. When that happens, nobody wins.

The Szilard Point is not some theoretical event horizon. It is where we are at right now. When the total cost of competing for a grant exceeds the value of available funding the system is seriously broken. We need innovative granting schemes and solutions not more of the same hunger games.

Beautiful work congrats everyone!

These 2 landmark papers came out at the start of my PhD. Science and clinic. Literally back to back. It has been an enduring inspiration ever since to be a part of this wonderful experiment called immunology.

Activation-induced cytidine deaminase: The missing piece of many puzzles Twenty-five years ago, two Cell papers reported the key missing functional piece in three molecular puzzles. The genetic swapping of immunoglobulin constant regions, the mutational fine-tuning of anti...

AID's role in class switch recombination & somatic hypermutation was published in @cellpress.bsky.social 25 years ago, a tour de force combo of mouse gene discovery & mechanistic work (Honjo lab) and human genetics (Durandy, Fischer et al).
What a privilege to write this with Sidonia & Masamichi

Prime editing-installed suppressor tRNAs for disease-agnostic genome editing - Nature A new strategy that uses prime editing to convert an endogenous tRNA into a suppressor tRNA shows therapeutic potential for multiple genetic diseases that are caused by premature stop codons.

This is next level out of this world! Disease agnostic in vivo prime editing!

www.nature.com/articles/s41...

Looking forward to this see you there Deepta!

Yea but how big was the photon? 😅

Out today in @nature.com: Together with the Honigmann, Shevchenko, Drobot and Hof labs, we present a general workflow for imaging the localization and transport of individual lipids in cells and mapping their metabolism.
www.nature.com/articles/s41...

Nice one congrats John et al!

Respiratory viral infections awaken metastatic breast cancer cells in lungs - Nature Mouse models show that respiratory infections from viruses such as influenza and SARS-CoV-2 can trigger metastasis of dormant breast cancer cells in the lungs, a finding supported by epidemiological d...

Out @nature.com led by @jdegregori.bsky.social Mercedes Rincon @roelvermeulen.bsky.social @jaguirreghisolab.bsky.social et al. in vivo mouse models & human data show resp. infections drive IL-6 dependent re-awakening of dormant cancer cells in lung.

So much to like about this paper! Congrats all!

Very excited at the chance to work with new people with new ideas in immunology! Really keen to hear from people from diverse backgrounds with different ways of thinking. International applicants seeking freedom to pursue BlueSky projects welcome. Come for the science. Stay for the vibe!
#immunosky

Now online in Cancer Discovery: AAnet Resolves a Continuum of Spatially-Localized Cell States to Unveil Intratumoral Heterogeneity - by Aarthi Venkat, Scott Youlten, Beatriz San Juan, Smita Krishnaswamy, Christine Chaffer, and colleagues doi.org/10.1158/2159...

Much obliged will do. 😊

😅

Yes please!

But sc data is noisy and nonlinear. AAnet takes archetype analysis to the next level by using an autoencoder to transform the data into a simplicial latent space. AAnet more accurately defines heterogeneity within cellular clusters & druggable transcriptional programs that drive heterogeneity. 3/3

Continuum of Gene-Expression Profiles Provides Spatial Division of Labor within a Differentiated Cell Type Single-cell gene expression reveals the diversity within a differentiated cell type. Often, cells of the same type show a continuum of gene-expression…

Cells exist in discrete cell states (clusters) but also cells show a continuum of gene expression (trajectory). @urialonlab.bsky.social first used archetype analysis to reconcile this paradox - the bioinformatic equivalent of wave-particle duality. This works if the ambient data space is linear. 2/3

Christine Chaffer, @skummerf.bsky.social at @garvaninstitute.bsky.social, Smita Krishnaswamy at Yale et al present AAnet a neural network for nonlinear archetype analysis that more accurately captures cell plasticity & learns the spatial organisation of the archetypes. What is the advance? 1/3

New Horizons for Multiple Sclerosis Therapy: 2025 and Beyond The advances achieved against multiple sclerosis (MS) represent one of the great success stories of modern molecular medicine. The development of therapies with increasing selectivity and safety, gui....

Very pleased to co-write this review with Bruce Cree and Steve Hauser on the future of #multiplesclerosis treatment

onlinelibrary.wiley.com/doi/10.1002/...

It was wonderful to meet with the #OCCAMS Consortium today on #WorldMSDay for an update on our study progress, as well as reviewing recent literature on the role of EBV in multiple sclerosis. Thanks to all participants for joining in the great discussions!
@garvaninstitute.bsky.social

What Have The Romans... - Monty Python's Life of Brian YouTube video by Monty Python

What have the National Institutes of Health ever done for us?

Thanks Kamila!

Evidence of innate lymphoid cell redundancy in humans - Nature Immunology The importance of human innate lymphoid cells to normal human physiology is unclear. Vivier and colleagues find that immunodeficient patients ‘rescued’ with normal bone marrow can recover their T cell...

Not sure if this is what you meant. DOCK8 deficiency (but not STAT3) is reported to have peripheral blood ILC3 defect which corrects after HSCT. In contrast, SCID patients may not reconstitute their NKs and ILCs after HSCT with no obvious health consequences suggesting they are dispensable.

Though every Cell paper is special, I occasionally get a paper that ✨delights✨ me from start to finish. These astute scientists found a unique opportunity to study an audacious snake venom enthusiast and uncovered antibodies that could serve as a broad antidote to snakebites. 🐍