Paul Ettel

Today, we see the fruit of 5+ years of teamwork. We have built a map of the neutrophil compartment (mostly in mice - but also humans). It provides a biological structure that focuses on a single immune cell lineage to discover the many ways in which neutrophils "interpret" physiology.

IRF4 is a master regulator of multinucleated giant cell formation Multinucleated giant cells (MGCs) are a hallmark pathological feature of a wide range of diseases, yet the mechanisms underlying their formation and function remain poorly understood. Although it is r...

just new at biorxiv...
IRF4 and multi-nucleated giant cells
www.biorxiv.org/cgi/content/...

Not turbo cancer but turbo cancer-immunotherapy!
Combining mRNA COVID vaccines with standard-of-care immune therapy overwhelms tumor defenses to improved survival in animal models and large cohorts of people with cancer @nature.com
www.nature.com/articles/d41...
www.nature.com/articles/d41...

Niche-specific dermal macrophage loss promotes skin capillary ageing
www.nature.com/articles/s41...

Neutrophils drive vascular occlusion, tumour necrosis and metastasis - Nature Neutrophils actively induce tumour necrosis, driving vascular occlusion, pleomorphic necrosis and metastasis.

I’m happy to share our latest work on tumour necrosis! During my time in the @megeblad.bsky.social lab, we found that tumour necrosis is not a passive phenomenon secondary to tumour growth, but an active phenomenon driven by neutrophils and NETs! Thread below: (1/13)
www.nature.com/articles/s41...

Epigenetic silencing of interleukin-10 by host-derived oxidized phospholipids supports a lethal inflammatory response to infections Upon pathogen detection, phagocytes trigger immunity. This process induces tissue stress and the formation of host-derived molecules that further tune immune responses. We show that host-derived oxidi...

#EpigeneticPower! 💥 #NewPaperAlert! We show @cp-immunity.bsky.social that endogenous oxidized lipids decide whether host survives or dies during #sepsis, #ARDS, or Staph infection! Ox lipids bind & inhibit #AKT, boosting inhibitory H3K27 methylation via EZH2 & blocking #IL10!

Paul Ettel, MD-PhD student in the lab has been awarded a prestigious Early Career Fellowship Grant from the Foundation for Sarcoidosis Research (FSR). FSR will support Paul’s research on the role of neutrophils and arginine metabolism in granuloma formation in sarcoidosis. Congratulations!

This grant will support my research for the next two years to further investigate how cellular metabolism shape granuloma development.
@weichhartlab.bsky.social

The Foundation for Sarcoidosis Research Awards $450,000 to Support Early-Career Investigators Through the 2025 Fellowship Grant FSR Early Career Fellowship Grant is designed to support early-career investigators in sarcoidosis....

Very happy to finally share the news that I am among this year's Early Career Fellowship Grant recipients by the Foundation of Sarcoidosis Research.
www.globenewswire.com/news-release...

Amitava Sinha via the @preprintclub.bsky.social‬ wrote a nice Journal Club article on a preprint by from the Angelo lab @stanfordmedicine.bsky.social that describes spatial immunometabolic zonation in tuberculosis granulomas: www.nature.com/articles/s41...

CHOP & @pennmedicine.bsky.social have delivered the first-ever personalized gene editing therapy for a patient with CPS1 deficiency, marking a major milestone in the application of CRISPR-based treatments.

Learn more about KJ & the future of personalized medicine: www.chop.edu/news/worlds-....

What a great conference in Crete! Very happy to be among the travel award recipients! See you in two years :))

This is just great

🚨 Groundbreaking study reveals how hypoxia shapes immune cell organization in #Tuberculosis granulomas, promoting Mtb persistence. Targeting these metabolic niches could revolutionize TB treatment strategies. A technical tour de force and a major scientific advance!
📖 shorturl.at/WkTgq

Cooperative nutrient scavenging is an evolutionary advantage in cancer - Nature Nutrient-starved tumour cells cooperate by secreting aminopeptidases that digest oligopeptides in the microenvironment, creating a shared pool of free amino acids.

Good one!
www.nature.com/articles/s41...

Spatially restricted and ontogenically distinct hepatic macrophages are required for tissue repair scRNA-seq has uncovered ontogenically distinct hepatic macrophage populations, but their functions remain unclear. Here, De Ponti et al. identify recruited LAMs and resident LAM-like KCs in multiple l...

With my first Bluesky post, I am very happy to share our latest study led by PhD student Federico De Ponti and postdoc Ania Bujko www.cell.com/immunity/ful...

www.immunometabolism.at/job-openings...

great opportunity to discover new aspects of immunometabolism...

SFB Immunometabolism Austria is looking for PhD students and postdocs. Highly recommended to join the team! Happy to answer any questions.
#immunometabolism #phd #postdoc
www.immunometabolism.at/job-openings/

1/n Some time ago my colleague, excellent cook, and friend Ivan told me: "Cacio e pepe is the recipe that I screw up more often. Let's make a project studying systematically the physics of that sauce".

Prepare to get cheesy, I'm glad to share the Cacio e paper preprint:

arxiv.org/abs/2501.00536

Today we report that an engineered skin bacterium, swabbed gently on the head of a mouse, can unleash a potent antibody response against a pathogen. Could lead to topical vaccines that are applied in a cream. @djenetbousbaine.bsky.social led the charge... @natureportfolio.bsky.social 1/55

Liver X receptor unlinks intestinal regeneration and tumorigenesis - Nature Liver X receptor drives epithelial Areg-mediated intestinal regeneration, while preventing tumour growth through adaptive immune responses.

Great paper by @ejvillablanca.bsky.social on LXR gut repair and tumorigenesis
www.nature.com/articles/s41...

Not just sugar: metabolic control of neutrophil development and effector functions We discuss how neutrophilic metabolism adapts during development, which metabolic pathways fuel their functionality, and how these processes are reconfigur

My (little) take on how metabolism regulates neutrophil development and functions and why it should be studied more. Happy if it is helpful to anyone interested!
academic.oup.com/jleukbio/art...

Impact of acute stress on murine metabolomics and metabolic flux - PubMed Plasma metabolite concentrations and labeling enrichments are common measures of organismal metabolism. In mice, blood is often collected by tail snip sampling. Here, we systematically examined the ef...

Not personally, but a colleague does a lot of plasma metabolomics. Usually fasts 6h.

pubmed.ncbi.nlm.nih.gov/37186827/