Brain-engrafted monocyte-derived macrophages from blood and skull-bone marrow exhibit distinct properties. @cp-neuron.bsky.social www.cell.com/neuron/fullt...
11.03.2026 14:40
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Brain-engrafted monocyte-derived macrophages from blood and skull-bone marrow exhibit distinct properties. @cp-neuron.bsky.social www.cell.com/neuron/fullt...
Excited to share our new study using engineered immune proteins to quench inflammation in aged brains!!
Congratulations to Paloma Navarro and the entire team!
Fantastic collaboration with Chris Garcia's lab, Tony Wyss-Coray's lab, and Saul Villeda's lab!
www.cell.com/immunity/ful...
Fintastic meeting as always, for those interested! #ZebrafishMeeting
🐟👀 SFSU Biology seminar — Thu Mar 5
2–3pm | SEC 116
Dr. Patricia Schneider (LSU): “Split Screens: Exploring Vision through the Eyes of the Four-Eyed Fish.”
Student time: 3–3:30pm. Come by!
Endogenous retrovirus-derived RNA-DNA hybrids induce microglial synaptic pruning in autism models @cp-neuron.bsky.social www.cell.com/neuron/fullt...
🧠 SFSU Biology Special Seminar
Dr. Biswa Ramani, MD, PhD (UCSF) — neurodegeneration + neuropathology + physician-scientist career path
📅 Wed 2/25/2026 • 🕙 10:00–11:40 • 📍 Hensill Hall 233 Hosted by @nicholasjsilva.bsky.social
All welcome!
Axolotls can completely rebuild their thymus, a key immune organ
Latest from the lab, led by @ara-donia.bsky.social and @juliavdkorput.bsky.social
Huge team effort, with immense contributions by friends from nearby and around the globe.
www.science.org/doi/10.1126/...
Congrats on the amazing story! 🥳
#fluorescencefriday distribution of microglia in the whole brain
I am SO incredibly excited to announce the launch of a global list of Inspiring Black Scientists. You can use this list to nominate and connect with researchers. Please share and join us in highlighting these outstanding scientists for #BlackHistoryMonth and beyond!
www.wiley.com/en-us/resear...
A lifelong passion for writing helped rising star @doctheagrif.bsky.social land a book deal and publish 15 chapter books for early readers, covering topics ranging from what the cerebellum does to how a cake bakes.
By @avaskham.bsky.social
www.thetransmitter.org/craft-and-ca...
Our paper is (finally) out in Cell today!
CRISPR screens in iPSC-derived neurons reveal principles of tau proteostasis
www.cell.com/cell/fulltex...
Great collaborative effort - read more from first author @asamelson.bsky.social below:
A landmark discovery in cancer neuroscience! Why is the incidence of Alzheimer’s disease (AD) lower in patients with a history of cancer? CELL: Peripheral cancer attenuates amyloid pathology in Alzheimer’s disease via cystatin-c activation of TREM2 www.cell.com/cell/fulltex...
We’re delighted to see this out today! Latest work from the lab reveals insights into the evolution of brain immunity and the developmental and evolutionary plasticity of lymphatic endothelial cells.
www.nature.com/articles/s41...
Ageing promotes microglial accumulation of slow-degrading synaptic proteins @nature.com
www.nature.com/articles/s41...
Proud to announce our collaboration with @blurtonjoneslab.bsky.social & the Paz lab showing that transplanted human iPSC-derived microglia in a PGRN KO mouse model restores progranulin in microglia and rescues pathology, circuitry, and behavior. Preprint out now: www.biorxiv.org/cgi/content/...
IFN-brite: A new interferon reporter from our lab designed by Dr. Sarah Anderson is bright and pan cellular
New discoveries are reshaping how scientists understand the molecular connections between the extracellular matrix and lysosomes—and the resulting implications for research and therapeutics for neurodegenerative disorders.
Learn more in this #ScienceSignaling Review: https://scim.ag/3Yi2sFS
Maspardin/SPG21 controls #lysosome motility and TFEB phosphorylation through RAB7 positioning, say Thomas Jacqmin, Marielle Boonen and colleagues (University of Namur): rupress.org/jcb/article/...
#Trafficking #Organelles #Disease
Phylogenetic tree showing relationships between zebrafish, mice and cartilaginous fishes. It shows the 3R genome duplication event in teleost lineage. Credit to MacDonald et al. 2018.
Did you know the last common ancestor of #zebrafish and humans was ~450 million years ago? A whole genome duplication event (3R) occurred early in the teleost fish phylogeny. Despite this event, zebrafish and humans have about the same number of chromosomes. #ZebrafishFunFacts 🧪
(A) Immobilized and agar-embedded zebrafish larvae are shown. Images were obtained using a 4× objective and 2× magnifier on an Olympus upright microscope during forebrain electrophysiological recordings in sibling control (A, left) and scn1Lab mutant (A, middle) larvae at 5 dpf. Note the dark pigmentation for mutants. Recording electrodes can be seen in panels A1-2 and the approximate site of the recording electrode tip in the forebrain (red circle) is shown using a representative HuC:GFP labeled larvae in A, right. Scale bar: 100 µm. (B) Sample locomotion tracking plot for sibling control (B, left) and scn1Lab mutant (B, right) larvae at 5 dpf. (C) Representative 10 min recording epochs obtained in the forebrain of paralyzed, immobilized and agar-embedded scn1Lab mutant larvae between 3 and 7 dpf. Note the presence of small and large amplitude spontaneous burst discharge; additional temporal expansions of seizure activity are shown in Supplemental Figure S1. A representative recording, under identical recording conditions, from a sibling control larvae at 5 dpf is also shown. Scale bar: 2 mV; 30 sec. Credit image and text to Baraban et al. (2013) Nature Communications
Dravet Syndrome is a genetic form of epilepsy caused by mutations in SCN1A. Researchers screened a library of compounds on loss-of-function scn1Lab (Nav1.1) #zebrafish and found clemizole (EPX-100) rescued the phenotype. This drug is now in Phase 3 Clinical Trials to treat seizures. #KnowYourZDM 🧪
Congrats! 🥳🥳
Time-lapse movie of mitochondria (blue) transport within neurons (green) in the tail of a transgenic #zebrafish larva. Credit to @paquetlab.bsky.social. #ZebrafishZunday 🧪
Two-photon imaging of pulsating brain activity in a #zebrafish larva that's having a seizure. Credit to Dr. Dominic Burrows. #ZebrafishZunday 🧪
“The only reason I don’t have this funding is because my last name is Rodriguez.”
MOSAIC checked many of the boxes of the administration — but that didn't matter. It was terminated, and left grantees scrambling
Next installment of American Science, Shattered:
www.statnews.com/2025/12/08/t...
“By performing longitudinal live imaging of intubated adult fish we observe vascular regrowth and immune responses to [meningeal cerebrovascular injuries] over time in the same animal with unprecedented resolution”
New work from #WeinsteinLab at NIH
Image of a TL adult zebrafish. Note the patchy spots and long fins. Credit to Alamy.
#ZebrafishFunFacts: Known to hobbyists as the leopard Danio, TL or Tüpfel longfin #zebrafish consist of two alleles (leo and lof). leo is a gap junction protein (ncbi.nlm.nih.gov/pmc/articles...), while lof is caused by upregulation of a K+ channel (journals.biologists.com/dev/article/...). 🧪 1/2
Slow-mo video of zebrafish mating. Credit to
@zebrafish007.bsky.social. #ZebrafishZunday 🧪
