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Carla Mulas

@cmulas

Principal Scientist at Altos Labs, Cambridge Institute. Interested in non-cell autonomous factors driving tissue aging and disease. Opinions are my own.

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18.12.2024
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Latest posts by Carla Mulas @cmulas

Flyer for symposium: https://ctrlepiedit.sciencesconf.org/

Flyer for symposium: https://ctrlepiedit.sciencesconf.org/

Very excited to announce the FIRST symposium on epigenome editing! These tools are becoming widely used in mol bio, ag & therapy. It's time to bring leaders together to discuss this rapidly growing and exciting field. And why not in Paris! Please register & share! (1/2) ctrlepiedit.sciencesconf.org

09.03.2026 13:15 πŸ‘ 77 πŸ” 55 πŸ’¬ 3 πŸ“Œ 5

Excited to share this new work from Ana Raffaelli, in collaboration with Ewa Paluch's lab and involving several of my colleagues at Cyclana Bio. In this paper, we show that basement membrane mechanics instructs developmental signalling and fate patterning.
www.biorxiv.org/content/10.6...

17.02.2026 13:16 πŸ‘ 14 πŸ” 5 πŸ’¬ 1 πŸ“Œ 0

Congratulations!!

04.02.2026 13:48 πŸ‘ 0 πŸ” 0 πŸ’¬ 1 πŸ“Œ 0
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The chromatin remodeller CHD4 regulates transcription factor binding to both prevent activation of silent enhancers and maintain active regulatory elements CHD4 directly limits transcription factor binding to chromatin, which prevents activation of silent or cryptic enhancers but facilitates activity of active enhancers.

Final version of our paper now published.
elifesciences.org/articles/109...

Take homes:
CHD4/NuRD directly limits transcription factor residence times. At active enhancers this keeps them working efficiently. At inactive enhancers it prevents TFs from getting a foothold and causing activation. 1/n

04.02.2026 08:17 πŸ‘ 29 πŸ” 11 πŸ’¬ 6 πŸ“Œ 0
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Induction of menstruation in mice reveals the regulation of menstrual shedding During menstruation, an inner layer of the endometrium is selectively shed, while an outer, progenitor-containing layer is preserved to support repeated regeneration. Progress in understanding this co...

I’m thrilled to share my postdoc work and the first paper from the McKinley Lab! πŸŽ‰
@karalmckinley.bsky.social
We built the first transgenic model of menstruation in mice.
We used it to uncover how the endometrium organizes and sheds during menstruation. πŸ§ͺ
www.biorxiv.org/content/10.1...
🧡

10.10.2025 12:50 πŸ‘ 232 πŸ” 83 πŸ’¬ 14 πŸ“Œ 15

Just over one week until this opportunity closes!

If you’re an ambitious computational scientist looking for a Postdoc position, apply now

07.10.2025 07:56 πŸ‘ 3 πŸ” 3 πŸ’¬ 1 πŸ“Œ 0

We've updated our first #preprint from the lab! A collaboration with @jamesbriscoe.bsky.social

πŸ”₯ now including in vivo 🐭&πŸ‘€ embryo data

www.biorxiv.org/content/10.1...

28.09.2025 10:04 πŸ‘ 41 πŸ” 11 πŸ’¬ 1 πŸ“Œ 1
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A dual enhancer-attenuator element ensures transient Cdx2 expression during mouse posterior body formation Amblard et al. dissect the function of cis-regulatory elements regulating transient Cdx2 expression during mouse caudal body formation. They highlight the requirement of an attenuator, a transiently r...

Great to see this from @vmetzis.bsky.social & co published

Dissection of CDX2 regulatory elements identifies a repressive element that converts to an enhancer with a nuclear receptor motif switch

www.cell.com/developmenta...

22.09.2025 15:34 πŸ‘ 28 πŸ” 7 πŸ’¬ 0 πŸ“Œ 1
hireful.

Exciting newsπŸ“£: #ProteostasisUK is hiring a network manager to help drive an ambitious, #BBSRC funded initiative connecting and expanding #Proteostasis research across the UK. Position initially for 3 years. Deadline September 28th. More info: tinyurl.com/f83rp673 & proteostasisuk.co.uk Please RT

02.09.2025 15:05 πŸ‘ 11 πŸ” 7 πŸ’¬ 1 πŸ“Œ 1

That’s awesome! When is the move?

20.08.2025 15:42 πŸ‘ 0 πŸ” 0 πŸ’¬ 1 πŸ“Œ 0
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Pathway to Independence – an interview with Anzy Miller Anzy Miller, former Sir Henry Wellcome Postdoctoral Fellow supported by Nancy Papalopulu (The University of Manchester, UK), is interested in the mechanisms involved in the generation of human pancrea...

My interview as part of @dev-journal.bsky.social Development's Pathway to Independence is live! I had a great time chatting to Saanjbati Adhikari - thank you.
journals.biologists.com/dev/article/...

04.08.2025 12:39 πŸ‘ 30 πŸ” 14 πŸ’¬ 0 πŸ“Œ 0

We wrote this introductory review on how concepts from dynamical systems can help us understand developmental biology, hope it’s useful to somebody! It was a lot of fun to put together, and great to collaborate with brilliant colleagues across theory and experiments

04.08.2025 14:46 πŸ‘ 26 πŸ” 10 πŸ’¬ 1 πŸ“Œ 0
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A do-or-die moment for the scientific enterprise Reflecting on our paper β€œThe entities enabling scientific fraud at scale are large, resilient, and growing rapidly”

Today, our article "The entities enabling scientific fraud at scale are large, resilient, and growing rapidly" is finally published in PNAS. I hope that it proves to be a wake-up-call for the whole scientific community.

reeserichardson.blog/2025/08/04/a...

04.08.2025 20:46 πŸ‘ 338 πŸ” 205 πŸ’¬ 9 πŸ“Œ 44
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Hendrich Group - Starting Sept 2025 - Living Systems Institute - University of Exeter Opportunity for LSI PHD studentship – starting in September 2025 or January 2026 PhD Studentship applications will open on 1st...

Funded PhD Studentship available in my lab at @lsiexeter.bsky.social.
Want to study how chromatin remodellers act on enhancers to facilitate cell fate decisions in human pluripotent cells? Want to work and live in a lively city by the sea? Get in touch/Apply!
lsi.exeter.ac.uk/groups/hendr...

12.04.2025 12:58 πŸ‘ 17 πŸ” 16 πŸ’¬ 0 πŸ“Œ 1
Post image

🌊 Nestled in the heart of the Calanques of Marseille, the IBDM offers an exceptional work environment 🌿✨

πŸ”¬ Conduct research with a sea view
🌞 Work in an inspiring natural setting
🌍 Combine scientific excellence with quality of life

Join us as a Group Leader: https://tinyurl.com/ukf2rn2x

14.03.2025 09:02 πŸ‘ 32 πŸ” 32 πŸ’¬ 1 πŸ“Œ 0
Development PI Programme | Development | The Company of Biologists Development PI Programme | Development | The Company of Biologists Development's Pathway to Independence programme Development is excited to announce our second call for our Pathway to I...

A couple of weeks left to apply to join Development's *Pathway to Independence* programme

Support & mentoring for post-docs on the academic job market

Deadline: January 31

journals.biologists.com/dev/pages/pi...

17.01.2025 09:21 πŸ‘ 26 πŸ” 36 πŸ’¬ 0 πŸ“Œ 0
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LSI PhD programme | Living Systems Institute | University of Exeter

Fully funded #PhD Studentship with myself and JJ Phillips at the Living Systems Institute, @uniofexeter.bsky.social

"Control of chromatin remodeller activity to direct cell fate decisions"

#Chromatin #Transcription #StemCells #StructuralBiology

Please re-skeet!

www.exeter.ac.uk/research/ins...

07.11.2024 07:17 πŸ‘ 12 πŸ” 24 πŸ’¬ 0 πŸ“Œ 1
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Hyaluronic Acid and Emergent Tissue Mechanics Orchestrate Digit Tip Regeneration Tissue regeneration is a dynamic process requiring coordinated cell fate decisions to restore structure and function. For instance, the tips of human and rodent digits fully regrow after amputation, a...

We are really proud to share the first 'Pre-Print' from the Storer lab driven by the fantastic Byron Mui, and co-lead by the innovative Kevin Chalut, on tissue mechanics, ECM and regeneration. A big thanks also to our collaborators in the Franze Lab.
www.biorxiv.org/content/10.1...

08.01.2025 12:12 πŸ‘ 34 πŸ” 15 πŸ’¬ 0 πŸ“Œ 2

🚨Why can’t mammals regenerate legs or arms like frog tadpoles or salamanders?
Our preprint tackles (part of) this BIG question with surprising findings about oxygen sensing
πŸ”— www.biorxiv.org/content/10.1...
Happy New Year, everyone! πŸŽ‰
🐭 vs 🐸 #evodevo #regenerative #cellbio πŸ§΅πŸ‘‡

06.01.2025 08:37 πŸ‘ 60 πŸ” 27 πŸ’¬ 3 πŸ“Œ 1

😱 sounds amazing… have fun!!

04.01.2025 10:47 πŸ‘ 0 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0