Genetically altered chimeric antigen receptor astrocytes targeting amyloid-β reduce a cardinal pathological feature of Alzheimer’s disease @science.org @washumedicine.bsky.social
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
A cochlea imaged in light-sheet microscopy (right) with staining for spiral ganglion neurons (red) and inner hair cells (blue). You will develop AI-based methods to analyze these structures, for example via segmentation of the individual cells (right) that will support gene therapy development for hearing loss and a better overall understanding of the anatomy of hearing.
Looking for a PhD position at the intersection of AI, imaging, and gene therapy? Apply for this position in my lab: tinyurl.com/2a2v6tvx
Part of sfb1690.uni-goettingen.de to study hearing, vision, and more.
Plus, you can create pretty pictures as the one below :).
🧪🦣🏺 I'm quoted here, and much of what I spoke about with Carl echoes April's comments.
Extra thoughts:
1. nice new piece for extending complexity in how we think about #Neanderthal interactions, though as authors note, multiple mechanisms (not just mate choice) possibly active in X chromo patterns
3i is hiring a Microscopist - repost & tell a friend!
Ideal candidate has experience in fundamental optical theory & familiarity with lightsheet, spinning disk, multiphoton, TIRF etc. Full-time, exempt position (travel to visit customers) offering a competitive salary & comprehensive benefits.
Our latest preprint, led by @lizihegarty.bsky.social & aided by @erinwatson.bsky.social shows that fixation time matters when it comes to visualising #macrophages in #salivarygland & other epithelia.We find 1hr allows detection of mac subsets while preserving architecture. With @bainlab.bsky.social
Fixation matters: duration in fixative prior to immunofluorescent analysis directly impacts macrophage visualisation in epithelial tissues https://www.biorxiv.org/content/10.64898/2026.02.13.705745v1
iconic shot of Lucas Pinheiro Braathen on the podium
no, it simply isnt.
People are talking about capital using gAI as an excuse to conduct mass lay-offs, about students losing learning because theyre being lied to about gAI in education, about the mass theft of the work of artists and authors to train LLMs, about CSAM and nonconsensual sexual images.
How did life arise from simple chemical building blocks?
New #LMBResearch led by @edogia.bsky.social in @philholliger.bsky.social group has identified a small self-replicating ribozyme that could be the answer.
Read more: mrclmb.ac.uk/news-events/...
Ooooh. Cool new paper on origins of life. A simple 45-nucleotide RNA molecule that can perfectly copy itself.
www.science.org/doi/10.1126/...
elodieunderglass I can confirm that most birds have a detectable amount of wiring behind the eyes - blinking lights and buttons and sliders and frizzy things that spark and chirp and beep. They also have a lot of soul that can communicate with ours because the programming is fairly compatible. Vultures are clever and curious, swans are clear and lawful, chickens have a lot of personality, caged parrots are dissociated and disinherited and frankly worrying, falconry-trained birds of prey are tremendously businesslike. And owls are absolutely lovely beasts with their own irreplaceable validity. but they are basically stuffed with polyester fiberfill. They have one button, like a child’s toy dinosaur that opens and closes its mouth when you press the back of its head. And it isn’t even a sophisticated electronic button it’s just a lever that rocks back and forth to make the claws open and close. I think they may have actually evolved independently from sponges. Their skulls simply exist to create holes that funnel sound and light, and as a place to hang a giant hinged beak. An owl is just an empty tube like a windchime that the wind whistles through, and you can drop meat down it. They use the meat to generate feathers, and then emit the bones in pressed little packages like those machines that flatten a penny and stamp it with the logo of a theme park. I think that’s the gist of it - most birds are electronics of varying levels of sophistication, but owls are just a system of levers and pulleys. No elevator music in those skulls, just the wind echoing through empty caverns of slightly irritating design. Absolutely fantastic.
finally found this tumblr post expounding on how stupid owls are piraticoctopus.tumblr.com/post/6741867...
🔬 In this new Open Access paper, the authors propose a new method that does not require a lot of computing power and works even for small datasets that are more typically seen in life sciences. To maintain competitive performance with respect to state-of-the-art methods, their denoising...
This looks phenomenal. I want to read every paper.
I have yet to see any evidence that there is a market for AI-generated books outside of people being tricked into thinking they are not AI-generated books. AKA, it is a project of scamming and deceiving people, and really should be treated as fraud
Prediction: In 10 years, “hardest problem” articles like this will shift from the challenge of ”C and perception“ to “C and emotions/mood“. The first is fascinating. The second is required to understand psychiatric functions & conditions.
www.scientificamerican.com/article/what...
Many people think that eating insects could be a good solution to climate change.
Nope. Not really.
Read more here, and see why Project Drawdown says this is "Not Recommended" as a climate solution.
drawdown.org/explorer/dep...
Expansion microscopy may be the hi-res hero that many biologists have been craving.
"Nested spatiotemporal theta–gamma waves organize hierarchical processing across the mouse visual cortex" www.nature.com/articles/s41...
traveling waves-related, supershiny looking figures, apparently made in Julia: github.com/brendanjohnh... makes me want to learn it 🙂
#VisualizationInspo
Draghi: “L’Europa diventi una vera federazione se vuole avere potere”
First dance
Book with paper roses
Laughing during a toast
You nerds will appreciate this.
I got married on Saturday! It was wonderful.
It was at a rare and historic book library, and we leaned into the theme.
Table centerpieces were books checked out of our library based on our interests, themed to that tables’ guests.
And Eileen made paper roses.
We have several Master’s thesis projects available in the D’Angelo lab, spanning different areas of lipid biology/biochemistry. If you know someone who might be interested, we’d really appreciate you sharing this. #lipidtime
www.epfl.ch/labs/dangelo...
… due to the fact that they cause faulty proteins to be made, but actually most of the dysfunction seems to occur in regulation.) So gene regulation is central to the way we work. But it is immensely complicated. /11
Norway’s oil fund yielded NOK 2362 billions in 2025, enough to DOUBLE the current budget of Norwegian Research Council for the next 214 years. 🤷♂️
www.nbim.no/no/nyheter-o...
🧪 We are excited to share this novel open access paper on Phasor Mixing Coefficient to analyze colocalization, developed by folks @i2janelia.bsky.social and @aicjanelia.bsky.social. This is also the first technical paper jointly published with our sister imaging center @malacridalab.bsky.social!
We have two funded postdoctoral positions available. Topics encompass:
-Next gen light-sheet fluorescence microscopy instrumentation
-Structured illumination microscopy and other approaches to extend the resolution limit.
-Nonlinear microscopy combined with adaptive optics / phase conjugation
One of the perks of living in San Francisco is free visits to the Photonics West trade show. Sharing my notes for those missing out: nicost.github.io/microscope-t...
Beautiful work once again with FIRE mice. Reprogramming microglia for the win!
9. We’ve become so used to all this that we hardly notice it. But isn’t it extraordinary? Almost everyone wants one thing, and almost everyone who represents us – whether in politics or the media – wants the opposite. Yet we tell ourselves we live in a democracy.
7. Immigrants, asylum seekers, Muslims, women, transgender people, disabled people, students, protesters: anyone and everyone must be blamed for our dysfunctions, except those causing them. Ever more extreme “culture wars” (a euphemism for divide-and-rule) must be waged.
