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@ewanmacdonald

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18.11.2024
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Latest posts by @ewanmacdonald

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📢 Seminar – Thurs, June 26, 11am @cnrsoccitanieest.bsky.social

🧪 Dr. Itay Budin (UC San Diego) will talk about how small lipid changes shape membranes & help marine life adapt to pressure/temp — with insights into climate resilience 🌊❄️🔥

📰 2023 Science paper: pubmed.ncbi.nlm.nih.gov/38935710/

18.06.2025 09:04 👍 1 🔁 2 💬 0 📌 1
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Cell scientist to watch – Francesca Bottanelli ABSTRACT. Francesca Bottanelli is an Assistant Professor in the Department of Biochemistry at Freie Universität Berlin (Germany). Francesca graduated in Plant Biotechnology from the University of Mila...

Nice interview with @franbottanelli.bsky.social in @jcellsci.bsky.social. Academics in Berlin, what are you waiting for? Fran wants to form a band!

journals.biologists.com/jcs/article/...

28.05.2025 06:26 👍 26 🔁 7 💬 2 📌 0
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Our newest paper is out in NCB. @jrwconway.bsky.social‬ designed a new FRET reporter, Illusia, to show the importance of integrin β1 phosphorylation dynamics in 3D invasion! Video: TNBC cells expressing Illusia with a Src (Saracatinib) or SHP2 (SHP099) inhibitor. www.nature.com/articles/s41...

26.05.2025 10:13 👍 40 🔁 11 💬 0 📌 0

🚨 New review out!
We explore how extracellular acidification shapes key processes like endocytosis, neurotransmission & immune responses — and highlight tools to study it.
📖 Read more [https://doi.org/10.1016/j.ceb.2025.102531]
w/ amazing collaborators 🙌 #CellBiology #Endocytosis #GPCR

15.05.2025 11:43 👍 0 🔁 1 💬 0 📌 0
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My choice this week in @science.org
www.nature.com/articles/s41...
@ewanmacdonald.bsky.social

11.04.2025 16:16 👍 23 🔁 3 💬 0 📌 0
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We've been studying mechanisms of resilience that protect lysosomes from damage and wrote a review on the topic. We consider lysosomal stress and damage on a spectrum. Please help me share as this is my first post 😀 and I don't have many followers! 🙏 Open Access: www.embopress.org/doi/full/10....

27.02.2025 15:54 👍 62 🔁 43 💬 0 📌 4
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Do not miss the #membrane seminars this THU! As usual zoom link and info here felixcampelo.wixsite.com/membranetraf... or via the mailing list lists.icfo.es/mailman/list... @felixmendu.bsky.social @ishier.bsky.social

24.02.2025 08:01 👍 23 🔁 16 💬 0 📌 1
JCI - Purifying and profiling lysosomes to expand understanding of lysosomal dysfunction–associated diseases

JCI - Purifying and profiling lysosomes to expand understanding of lysosomal dysfunction–associated diseases www.jci.org/articles/vie...

24.02.2025 02:54 👍 4 🔁 1 💬 0 📌 0
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Spatial N-glycan rearrangement on α5β1 integrin nucleates galectin-3 oligomers to determine endocytic fate Membrane glycoproteins frequently adopt different conformations when altering between active and inactive states. Here, we discover a molecular switch that exploits dynamic spatial rearrangements of N...

... and soon the structural glycoswitch: www.biorxiv.org/content/10.1...

22.02.2025 22:31 👍 4 🔁 2 💬 0 📌 0
"Growth factor-triggered de-sialylation 
controls glycolipid-lectin-driven endocytosis"
An excellent collaboration between the US, India, Denmark, UK, Netherlands and France.

"Growth factor-triggered de-sialylation controls glycolipid-lectin-driven endocytosis" An excellent collaboration between the US, India, Denmark, UK, Netherlands and France.

Growth factors trigger receptor desialylation at the plasma membrane, galectin binding and subsequent endocytosis.

=> A proton pump driven glycoswitch @naturecellbiology.bsky.social :

rdcu.be/eaLM9

#glycotime, @institutcurie.bsky.social, @cnrs.fr, @inserm.fr, #NIH, #CellBiol, #Cancer

22.02.2025 22:31 👍 16 🔁 3 💬 2 📌 1

Thrilled to share our latest publication! We describe a novel acid-dependent mechanism regulating clathrin-independent endocytosis. This study was a fantastic collaborative effort with the labs of Ludger Johannes, Roberto Weigert, and Satyajit Mayor. nature.com/articles/s4155….

22.02.2025 10:45 👍 3 🔁 1 💬 0 📌 1
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Happy to contribute to the analysis of β1integrin endocytosis using @the.3i.social LLSM, now in @naturecellbiology.bsky.social
rdcu.be/eaLM9
L. Leconte @christianwunder.bsky.social @aforrester.bsky.social @ewanmacdonald.bsky.social @institutcurie.bsky.social #inria @france-bioimaging.bsky.social

22.02.2025 09:01 👍 13 🔁 6 💬 0 📌 2
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Live imaging of the extracellular matrix with a glycan-binding fluorophore - Nature Methods Rhobo6 is a cell-impermeable small-molecule fluorophore that displays reversible fluorogenic binding to glycans, making it a general, wash-free, and non-perturbative label for the extracellular matrix...

Check it out, powerful new method for optical imaging of the live ECM, from @hhmijanelia.bsky.social Group Leader Kayvon Pedram #proudofalumni #glycotime

www.nature.com/articles/s41...

06.02.2025 22:59 👍 138 🔁 32 💬 2 📌 0
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ÅNGSTRÖM-RESOLUTION IMAGING OF CELL-SURFACE GLYCANS 🧬🎨🍬

The glycocalyx, our cells' sugar coat, holds secrets in immunology, cancer, viral infections, and more. Visualizing its molecular architecture was impossible… until now. #glycotime #microscopy

www.biorxiv.org/content/10.1...

10.02.2025 08:21 👍 314 🔁 101 💬 15 📌 15
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Flotillins in membrane trafficking and physiopathology Flotillin 1 and 2 scaffold sphingolipid-rich membrane microdomains involved in endocytosis and  endolysosome maturation through the generation of sphingosine 1-phosphate (S1P) by sphingosine kinase 2...

I'm happy to share our review latest review on flotillins! We discuss the recent insights into the structure of these interesting proteins from cyro-EM studies.
doi.org/10.1111/boc....

29.01.2025 11:20 👍 4 🔁 1 💬 0 📌 0