Stabilizing the hepatitis C virus E1E2 glycoprotein complex—long a barrier to HCV vaccine design—Scripps Research scientists displayed engineered proteins on self-assembling nanoparticles, eliciting immune responses in a new @natcomms.nature.com study.
PIEZO2—unlike PIEZO1—is tethered to the actin cytoskeleton, enabling sensory neurons to detect localized mechanical forces such as light touch.
Findings reported in @nature.com by @ericmulhall.bsky.social from @ardemp.bskyverified.social's lab link nanometer-scale imaging to sensory function.
Very excited to share our new manuscript – published today!
Why are PIEZO1 and PIEZO2 are tuned to transduce different types of mechanical force? I was lucky to work with some extraordinary colleagues to begin to figure out why.
www.nature.com/articles/s41...
An overview of the results below ⬇️ ⬇️
New paper from the lab led by @ericmulhall.bsky.social addresses how PIEZO1 and PIEZO2 are tuned to different types mechanical forces. From nanometer-scale super-resolution microscopy to in vivo experiments, links single-molecule observations to physiological function.
www.nature.com/articles/s41...
A @natchembio.nature.com study led by Assoc. Prof. @michael-erb.bsky.social describes a strategy to deliberately discover “molecular glue” degraders by converting existing protein binders into compounds that recruit the cell’s disposal machinery, selectively degrading ENL and BRD4.
Scripps Research welcomes healthcare innovator Joe Kiani to its Board of Directors. Kiani brings decades of experience in patient safety and public service, and is the founder of Willow Laboratories and Masimo, known for advancing noninvasive patient monitoring technologies.
We’re delighted to be able to announce Keary Engle (Scripps Research) and Garret Miyake (Colorado State University) as the joint winners of the 2025 #ChemSocRev Pioneering Investigator Lectureship!
@nsfsuprcat.bsky.social
blogs.rsc.org/cs/2026/02/2...
Today, 1 in 10 Americans lives with a rare disease. Most of the 7,000+ identified worldwide still have no approved treatment.
Last year, @scripps.edu added its 18th FDA-approved medicine for one of these conditions—advancing options for patients with few alternatives. #RareDiseaseDay
Do you ♥️ Rhinos, @sandiegozoo.bsky.social and @scripps.edu and @statnews? Then spread the love by voting for them in (insert round) of #STATMadness: www.statnews.com/feature/stat...
Defined protein filament networks discovered inside biomolecular condensates reveal new targets for cancer and neurodegenerative disease, as shown in findings from @scripps.edu Prof. @kerenlasker.bsky.social, Prof. Ashok Deniz and Asst. Prof. @raphaelpark.bsky.social.
Congrats to postdoctoral researcher Kai Sheng on receiving a 2026 Outstanding Doctoral Research in Biophysics Award from
@biophysicalsoc.bsky.social! 🎉
His work reveals how bacterial ribosomes assemble, producing the most detailed structural map to date.
Beyond scientific research and formal graduate education, Scripps Research believes in the power of outreach programs to inspire, educate and equip future generations of scientists—through community outreach initiatives for all ages and backgrounds.
Chuffed to see our paper with @geneyeo.bsky.social finally published in @nature.com.
www.nature.com/articles/s41...
Very grateful to Fede, Susie, and Dave from my lab, and Sammi, Eric, and Pratibha from Gene's lab. What did we find? ⬇️ ⬇️ ⬇️
Scripps Research Prof. Dale Boger has developed a new molecule with the potential to protect against resistance for decades to come. To get the next-generation antibiotic into the hands of patients, however, will require external support for preclinical trials. More: ow.ly/5ths50YklTW
#ICYMI: Scripps Research Prof. Kim Janda was featured by @kpbssandiego.bsky.social for his work redesigning fentanyl’s core structure to preserve pain relief while reducing dangerous respiratory depression, highlighting potential new paths toward safer pain therapies.
Stick chemistry: High-throughput method for finding new molecular glues. A visualization of a new molecular-glue degrader bound to cereblon and a protein target of interest.
Molecular glues are enjoying the spotlight, but discovering new ones is often a matter of luck. A new method, developed by @scripps.edu chemist @michael-erb.bsky.social and colleagues, aims to discover new glues more intentionally with a “target-based” approach. cen.acs.org/biological-c...
#chemsky🧪
A study by Scripps Research and @ucsandiego.bsky.social reports that subsets of hippocampal memory neurons occupy distinct high and low translation states. Published in @nature.com and co-led by @lippilab.bsky.social, the work maps protein production across ~20,000 single cells using Ribo-STAMP.
What a thrill to see this out! Our prospective, scalable, and target-centric solution for molecular glue discovery.
More thoughts and details here: www.linkedin.com/posts/activi...
Paper here: www.nature.com/articles/s41...
Calibr-Skaggs at Scripps Research and Kainomyx, Inc., today announced a new research collaboration, supported by the Gates Foundation, to pioneer novel malaria treatments that target parasite cytoskeletal pathways, with a focus on global access and affordability. More: ow.ly/z8wY50Yhi23
Assoc. Prof. @xinjin.bsky.social has been named a 2026 Sloan Research Fellow by the @sloanfoundation.bsky.social, recognized for pioneering in vivo Perturb-seq—a gene-editing approach combining CRISPR technology and single-cell RNA analysis to uncover how genetic variation shapes brain development.
Photographed Barry Sharpless at @scripps.edu. Two Nobels, for mastering chirality and inventing click chemistry. In his crowded office he spoke softly about life’s fragility and wonder. Still curious; still in awe. More: explorers.com/barry-sharpl...
@nobelprize.org @nationalacademies.org #SciArt
"When I started doing chemistry, I did it the way I fished: for the excitement, the discovery, the adventure, for going after the most elusive catch imaginable in uncharted seas."
- 2x @nobelprize.org winner, Barry Sharpless. @scripps.edu @nationalacademies.org @nasonline.org #SciArt
Congrats to Prof. Jeffery Kelly on being named to the
@forbes.com Innovator 250 list! Recognized for co-founding FoldRx and advancing tafamidis—an FDA-approved drug for heart disease and neurodegeneration—his work helped lay the foundation for new therapeutic strategies.
Explore some of the most promising areas of regenerative medicine research at Scripps Research and Calibr-Skaggs at: www.scripps.edu/news-and-eve...
Not all matters of the heart are metaphorical, including a damaged one ❤️🩹
Scripps Researchers are working with scientists at Calibr-Skaggs to advance regenerative approaches that could help injured heart tissue repair itself, moving beyond symptom management toward restoring function.
I photographed @erictopol.bsky.social at @scripps.edu. Calm, curious, grounded in evidence. No supplement hype. No product sponsorships. Just data. Diet, sleep, exercise, prevention. In a noisy longevity world, he’s a steady voice for real science. explorers.com/eric-topol/ @nationalacademies.org
Promotional graphic featuring the table of contents image along with the journal and article title.
'Fentanyl-Rewired: A 2-Azaspiro[3.3]heptane Core Preserves μ-Opioid Function' from ACS Medicinal Chemistry Letters is currently free to read as an #ACSEditorsChoice.
📖 Read the article: buff.ly/UgZCCza
@scripps.edu
Chemists led by Scripps Research Professor Kim Janda report a core structural redesign of fentanyl that reduces respiratory depression while fully preserving its pain-relieving properties, as described in a study published in @acs.org and recognized in the #ACSEditorsChoice collection.
Congratulations to Scripps Research professor Darrell Irvine, who is featured in the 2026 TIME100 Health list. Irvine is recognized for his work in empowering the immune system to fight disease, including developing vaccines against HIV and cancer. More: ow.ly/orAY50YcZFx
